Fei He   Hitomi Nakamura   Shotaro Hoshino   Joyce Seow Fong Chin   Liang Yang   Huiping Zhang   Fumiaki Hayashi   Ikuro Abe   
Journal of natural products 81(6) 1493-1496 2018年6月
Four new catechol derivatives, hinduchelins A-D (1-4), composed of 2,3- dihydroxybenzoic acid, threonine, and decarboxylated phenylalanine, were isolated from Streptoalloteichus hindustanus. Their structures and absolute configurations were elucid...
So-Yeun Woo   Nwet Nwet Win   Chin Piow Wong   Takuya Ito   Shotaro Hoshino   Hla Ngwe   Aung Aung Aye   Nang Mya Han   Huiping Zhang   Fumiaki Hayashi   Ikuro Abe   Hiroyuki Morita   
Journal of natural medicines 72(3) 803-807 2018年6月
Marine organisms such as marine sponges and soft corals are valuable sources of pharmacologically active secondary metabolites. In our ongoing research on the discovery of new secondary metabolites from marine organisms, two new pyrrolo-2-aminoimi...
Non-heme iron and α-ketoglutarate (αKG) oxygenases catalyze remarkably diverse reactions using a single ferrous ion cofactor. A major challenge in studying this versatile family of enzymes is to understand their structure-function relationship. Au...
Chemical & pharmaceutical bulletin 66(6) 660-667 2018年
Mycolic acid-containing bacteria (MACB) are known to activate cryptic natural product biosynthesis in co-cultures with actinobacteria. We cultured Actinosynnema mirum NBRC 14064, a producer of the mono-cyclic polyene macrolactam mirilactam A (6), ...
Takahiro Mori   Taiki Iwabuchi   Shotaro Hoshino   Hang Wang   Yudai Matsuda   Ikuro Abe   
Nature chemical biology 13(10) 1066-1073 2017年10月
Trt14 from Aspergillus terreus is involved in unusual skeletal reconstruction during the biosynthesis of the fungal meroterpenoid terretonin. Detailed in vitro characterization revealed that this novel multifunctional enzyme catalyzes not only the...