Fused in sarcoma (FUS) and splicing factor, proline- and glutamine-rich (SFPQ) are RNA binding proteins that regulate RNA metabolism. We found that alternative splicing of the Mapt gene at exon 10, which generates 4-repeat tau (4R-T) and 3-repeat ...
Jun Yoshitake Yoshiyuki Soeda Tomoaki Ida Akio Sumioka Misato Yoshikawa Kenji Matsushita Takaaki Akaike Akihiko Takashima
JOURNAL OF BIOLOGICAL CHEMISTRY 291(43) 22714-22720 2016年10月 [査読有り]
Neurofibrillar tangles caused by intracellular hyperphosphorylated tau inclusion and extracellular amyloid peptide deposition are hallmarks of Alzheimer's disease. Tau contains one or two cysteine residues in three or four repeats of the microtubu...
Mikko T. Huuskonen Sanna Loppi Hiramani Dhungana Velta Keksa-Goldsteine Sighild Lemarchant Paula Korhonen Sara Wojciechowski Eveliina Pollari Piia Valonen Juho Koponen Akihiko Takashima Gary Landreth Gundars Goldsteins Tarja Malm Jari Koistinaho Katja M. Kanninen
SCIENTIFIC REPORTS 6 33176 2016年9月 [査読有り]
Stroke is a highly debilitating, often fatal disorder for which current therapies are suitable for only a minor fraction of patients. Discovery of novel, effective therapies is hampered by the fact that advanced age, primary age-related tauopathy ...
Journal of Endodontics 42(3) 397-401 2016年3月 [査読有り]
Introduction This study was designed to evaluate the usefulness of magnetic resonance imaging (MRI) to assess the regeneration of pulp tissue. Methods Mobilized dental pulp stem cells and granulocyte colony-stimulating factor with collagen were tr...
人文科学研究科