Biochimica et biophysica acta. General subjects 1866(7) 130135-130135 2022年7月
BACKGROUND: In Alzheimer's disease (AD), abnormally phosphorylated tau in the somatodendrite compartment of brain neurons causes synaptic loss, resulting in neuron death. Although the mechanism by which hyperphosphorylated tau appears in dendrites...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of extracellular amyloid-beta peptides (Aβ) resulting in senile plaques and intracellular hyperphosphorylated tau protein resulting in neurofibrillary tangl...
Yuta Takaichi   James K Chambers   Yasuhisa Ano   Akihiko Takashima   Hiroyuki Nakayama   Kazuyuki Uchida   
Journal of Neuropathology & Experimental Neurology 80(8) 731-740 2021年6月 [査読有り]
<title>Abstract</title>
The simultaneous accumulation of multiple pathological proteins, such as hyperphosphorylated tau (hp-tau) and phosphorylated α-synuclein (p-αSyn), has been reported in the brains of patients with various neurodegenerative ...
Yuta Takaichi   Yasuhisa Ano   James Ken Chambers   Kazuyuki Uchida   Akihiko Takashima   Hiroyuki Nakayama