高島明彦

研究者氏名	高島明彦
	タカシマアキヒコ
URL
所属	学習院大学
部署	理学部生命科学科
職名	教授
学位	理学博士
J-Global ID	200901009923564735

研究キーワード

老化 ,脳神経疾患 ,神経科学

研究分野

ライフサイエンス / 神経科学一般 /

学歴

1981年3月

九州大学大学院

1979年3月

九州大学理学部生物学科

論文

12 3 4 5 >

Clinical and Pathological Features of FTDP-17 with MAPT p.K298_H299insQ Mutation.

Hiroyuki Morino Takashi Kurashige Yukiko Matsuda Maiko Ono Naruhiko Sahara Tomohiro Miyasaka Yoshiyuki Soeda Hitoshi Shimada Yu Yamazaki Tetsuya Takahashi Yuishin Izumi Hidefumi Ito Hirofumi Maruyama Makoto Higuchi Koji Arihiro Tetsuya Suhara Akihiko Takashima Hideshi Kawakami

Movement disorders clinical practice 2024年4月

BACKGROUND: MAPT is a causative gene in frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), a hereditary degenerative disease with various clinical manifestations, including progressive supranuclear palsy, corticobasal syn...

Research on the molecular mechanism of singularity phenomenon in neurological disorders

Hiroko Bannai Akihiko Takashima Yoshiyuki Soeda Hideaki Yoshimura Gen Matsumoto Naruhiko Sahara Michio Hiroshima Mitsuru Hattori Takeharu Nagai

Biophysics and Physicobiology 2024年 [査読有り]

Path integration deficits are associated with phosphorylated tau accumulation in the entorhinal cortex.

Riki Koike Yoshiyuki Soeda Atsushi Kasai Yusuke Fujioka Shinsuke Ishigaki Akihiro Yamanaka Yuta Takaichi James K Chambers Kazuyuki Uchida Hirohisa Watanabe Akihiko Takashima

Brain communications 6(1) fcad359 2024年

Alzheimer's disease is a devastating disease that is accompanied by dementia, and its incidence increases with age. However, no interventions have exhibited clear therapeutic effects. We aimed to develop and characterize behavioural tasks that all...

Path integration deficits predict phosphorylated tau accumulation in the entorhinal cortex: Assessment of Braak stage I,II using 3D Virtual reality goggles

Akihiko Takashima Riki Koike Yoshiyuki Soeda Yusuke Fujioka Shinsuke Ishigaki Hirohisa Watanabe

Alzheimer's & Dementia 19(S22) 2023年12月

Abstract

Background

We aimed to develop behavioral tasks that can identify early signs of Alzheimer’s disease (AD) in order to facilitate the development of preventative and therapeutic interventions.

Method

To do this, we created a 3D virtual...

Tryptophan-tyrosine dipeptide improves tau-related symptoms in tauopathy mice.

Yasuhisa Ano Yuta Takaichi Rena Ohya Kazuyuki Uchida Hiroyuki Nakayama Akihiko Takashima

Nutritional neuroscience 1-12 2022年7月

Neurodegenerative diseases involving pathological tau protein aggregation are collectively known as tauopathies and include Alzheimer's disease and Pick's disease. Recent studies show that the intake of tryptophan-tyrosine (Trp-Tyr)-related β-lact...