Chemical and Pharmaceutical Bulletin 38(11) 3164-3166 1990年
Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the...
In the presence of a chiral diamine, the magnesium salt of tolyl sulfone reacts with acetone at the α-carbon to afford the corresponding β-hydroxy adduct in good optical purity.
α-Phenylthio-α,β-unsaturated ketones are prepared in fairly good yields on treatment of α-sulfinyl ketone with stannous triflate. α-Phenylthio-α,β-unsaturated cyanides are also prepared from α-sulfinyl cyanides according to the similar procedure.
Journal of the American Chemical Society 140(20) 6203-6207 2018年5月
Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp3)-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp3)-H bond functionali...
The Tishchenko reaction is one of the useful methods for ester synthesis. Intra- and intermolecular Tishchenko reactions using metallic zinc are described. A practical Tishchenko reaction using metallic zinc was applied to various benzaldehydes to...
Keiji Mori   Hiroki Kishi   Takahiko Akiyama   
SYNTHESIS-STUTTGART 49(2) 365-370 2017年1月
We report herein a highly efficient kinetic resolution of PHANOL by chiral phosphoric acid catalyzed asymmetric acylation. PHANOL enantiomers were well differentiated by the chiral environment of chiral phosphoric acid, and both the corresponding ...