L-Quebrachitol (1L-(-)-2-O-methyl-chiro-inositol) is a naturally abundant chiral cyclitol obtained from the serum of the rubber tree. Although total syntheses of natural products starting from L-quebrachitol have been studied extensively, asymmetr...
T AKIYAMA   H HIROFUJI   S OZAKI   
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 65(7) 1932-1938 1992年7月 [査読有り]
A combination system of AlCl3-N,N-dimethylaniline was found to cleave benzyl ethers readily to give parent alcohols in excellent yields. The system also cleaved allyl as well as methyl ethers. Numerous functional groups such as benzoyloxy, phenylt...
Racemic 1,2:5,6-di-O-cyclohexylidene- and 1,2:3,4-di-O-cyclohexylidene-myo-inositol were resolved by enzyme catalyzed esterification in organic solvent.
T AKIYAMA   N TAKECHI   S OZAKI   K SHIOTA   
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 65(2) 366-372 1992年2月 [査読有り]
A naturally occurring optically active cyclitol, L-quebrachitol (1L-2-O-methyl-chiro-inositol), was stereoselectively transformed into myo-inositol derivatives via an oxidation-reduction process. The methyl ether was cleaved chemoselectively with ...
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 64(7) 2266-2269 1991年7月 [査読有り]
5'-O-Acryloyl-5-fluorouridine was prepared by use of p-methoxybenzyl (PMB) group as an N3-imide protecting group of 5-fluorouridine. PMB group was introduced chemoselectively by use of N,N-diisopropylethylamine or DBU as a base. A new deprotection...
Journal of the American Chemical Society 140(20) 6203-6207 2018年5月
Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp3)-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp3)-H bond functionali...
The Tishchenko reaction is one of the useful methods for ester synthesis. Intra- and intermolecular Tishchenko reactions using metallic zinc are described. A practical Tishchenko reaction using metallic zinc was applied to various benzaldehydes to...
Keiji Mori   Hiroki Kishi   Takahiko Akiyama   
SYNTHESIS-STUTTGART 49(2) 365-370 2017年1月
We report herein a highly efficient kinetic resolution of PHANOL by chiral phosphoric acid catalyzed asymmetric acylation. PHANOL enantiomers were well differentiated by the chiral environment of chiral phosphoric acid, and both the corresponding ...