Benzothiazoline proved to be an efficient reducing agent for the phosphoric acid-catalyzed enantioselective transfer hydrogenation reaction of imines. Corresponding amines were obtained with excellent enantioselectivities.
T Akiyama   K Matsuda   K Fuchibe   
SYNLETT (11) 1898-1900 2002年11月 [査読有り]
The montmorillonite K10-catalyzed aza Diels-Alder reaction of Danishefsky's diene with aldimines, generated in situ from aliphatic aldehydes and p-anisidine, proceeded smoothly in H2O or in aqueous CH3CN to afford 2-substituted 2,3-dihydro-4-pyrid...
T Akiyama   K Asayama   S Fujiyoshi   
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (22) 3655-3656 1998年11月 [査読有り]
On treatment of diallyldiisopropylsilane and alpha,beta-unsaturated ketones with BF3. OEt2, 1,4-addition of an allyl moiety and subsequent intramolecular allylation onto the beta-silyl carbocation intermediate furnished domino allylation products....
On treatment of allyl-t-butyldiphenylsilane with t-BuOK and 18-Crown-6 in DMSO at room temperature, isomerization of the olefinic double bond and subsequent substitution of phenyl group with hydroxy group took place smoothly to afford alkenylsilan...
Journal of the American Chemical Society 140(20) 6203-6207 2018年5月
Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp3)-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp3)-H bond functionali...
The Tishchenko reaction is one of the useful methods for ester synthesis. Intra- and intermolecular Tishchenko reactions using metallic zinc are described. A practical Tishchenko reaction using metallic zinc was applied to various benzaldehydes to...
Keiji Mori   Hiroki Kishi   Takahiko Akiyama   
SYNTHESIS-STUTTGART 49(2) 365-370 2017年1月
We report herein a highly efficient kinetic resolution of PHANOL by chiral phosphoric acid catalyzed asymmetric acylation. PHANOL enantiomers were well differentiated by the chiral environment of chiral phosphoric acid, and both the corresponding ...