The hydrosilylation of alkenes is one of the most important methods for the synthesis of organosilicon compounds. In addition to the platinum‐catalyzed hydrosilylation, silyl radical addition reactions are notable as economic reactions. ...
Comprehensive Organic Synthesis: Second Edition 2 629-681 2014年2月
The Mannich reaction is a useful method for the preparation of β-amino carbonyl compounds of biological interest starting from aldehyde, amine, and carbonyl compounds. The classical Mannich reaction was limited to highly reactive aldehydes such as...
A highly enantioselective fluorination of beta-ketoesters catalyzed by chiral sodium phosphate is achieved. In this process, the simultaneous formation of sodium enolate and sodium phosphate under basic conditions is the key to achieving excellent...
Described herein is a [1,4]-hydride shift mediated expeditious synthesis of 1-aminoindane derivatives. A wide variety of substrates could be employed in this reaction to afford various indane derivatives in good to excellent chemical yields. Exami...
We describe herein a chiral phosphoric acid catalyzed Friedel-Crafts reaction of indoles with β-alkoxycarbonyl-β-disubstituted nitroalkenes. A wide variety of substrates participated in this reaction to afford indoles having all-carbon quaternary ...
A good mix: The title reaction of o-alkynylacetophenones with the Hantzsch ester in the presence of a chiral copper/phosphate catalyst proceeds in good yields with excellent enantioselectivities. The key intermediate for enantiocontrol is the ion ...
人文科学研究科
理学部