The hydrosilylation of alkenes is one of the most important methods for the synthesis of organosilicon compounds. In addition to the platinum‐catalyzed hydrosilylation, silyl radical addition reactions are notable as economic reactions. ...
We synthesized chiral phosphoric acids bearing 3,3′-substituents starting from (R) -BINOL and demonstrated their catalytic activity as chiral Bransted acid. Proper choice of the 3,3′-substituents of the phosphoric acid is critical to attain excell...
Reductive amination of aldehyde and amine proceeded smoothly in the presence of benzothiazoline as efficient hydrogen source by means of 20 mol% trifluoroacetic acid to give the corresponding amines in excellent yields. Hydrogen-donor abilities of...
Reductive amination of aldehyde and amine proceeded smoothly in the presence of benzothiazoline as efficient hydrogen source by means of 20 mol% trifluoroacetic acid to give the corresponding amines in excellent yields. Hydrogen-donor abilities of...
Wataru Kashikura   Keiji Mori   Takahiko Akiyama   
Organic Letters 13(7) 1860-1863 2011年4月
A biphenol-based chiral phosphoric acid bearing a 9-anthryl group at each of the 3,3′-positions catalyzed the asymmetric Mannich-type reaction of N-Boc imine with difluoroenol silyl ethers in the presence of MS3A in THF to afford β-amino-α,α-diflu...
Keiji Mori   Kensuke Ehara   Kazuki Kurihara   Takahiko Akiyama   
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 133(16) 6166-6169 2011年4月
Chiral phosphoric acid-catalyzed asymmetric C-H functionalization has been achieved. In this process, enantiotopic C(sp(3))-hydrogen is selectively activated by chiral phosphoric acid to afford tetrahydroquinoline derivatives with excellent enanti...