高島明彦

タカシマアキヒコ (Akihiko Takashima)

基本情報

所属: 学習院大学理学部生命科学科教授

学位: 理学博士

J-GLOBAL ID: 200901009923564735
researchmap会員ID: 5000101447

研究キーワード

研究分野

ライフサイエンス / 神経科学一般 /

学歴

- 1981年3月

九州大学大学院
- 1979年3月

九州大学理学部生物学科

論文

189

Modification of Tau by 8-Nitroguanosine 3,5-Cyclic Monophosphate (8-Nitro-cGMP): EFFECTS OF NITRIC OXIDE-LINKED CHEMICAL MODIFICATION ON TAU AGGREGATION

Jun Yoshitake, Yoshiyuki Soeda, Tomoaki Ida, Akio Sumioka, Misato Yoshikawa, Kenji Matsushita, Takaaki Akaike, Akihiko Takashima

JOURNAL OF BIOLOGICAL CHEMISTRY 291(43) 22714-22720 2016年10月査読有り
Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Mikko T. Huuskonen, Sanna Loppi, Hiramani Dhungana, Velta Keksa-Goldsteine, Sighild Lemarchant, Paula Korhonen, Sara Wojciechowski, Eveliina Pollari, Piia Valonen, Juho Koponen, Akihiko Takashima, Gary Landreth, Gundars Goldsteins, Tarja Malm, Jari Koistinaho, Katja M. Kanninen

SCIENTIFIC REPORTS 6 33176 2016年9月査読有り
Assessment of pulp regeneration induced by stem cell therapy by magnetic resonance imaging

Koichiro Iohara, Masanori Fujita, Yoshiko Ariji, Misato Yoshikawa, Hideto Watanabe, Akihiko Takashima, Misako Nakashima

Journal of Endodontics 42(3) 397-401 2016年3月1日査読有り
The advantages of structural equation modeling to address the complexity of spatial reference learning

Pedro S. Moreira, Ioannis Sotiropoulos, Joana Silva, Akihiko Takashima, Nuno Sousa, Hugo Leite-Almeida, Patrício S. Costa

Frontiers in Behavioral Neuroscience 10 2016年2月26日査読有り
Glycogen Synthase Kinase 3β-mediated Phosphorylation in the Most C-terminal Region of Protein Interacting with C Kinase 1 (PICK1) Regulates the Binding of PICK1 to Glutamate Receptor Subunit GluA2.

Yagishita S, Murayama M, Ebihara T, Maruyama K, Takashima A

The Journal of biological chemistry 290(49) 29438-29448 2015年12月査読有り
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

Yoshiyuki Soeda, Misato Yoshikawa, Osborne F. X. Almeida, Akio Sumioka, Sumihiro Maeda, Hiroyuki Osada, Yasumitsu Kondoh, Akiko Saito, Tomohiro Miyasaka, Tetsuya Kimura, Masaaki Suzuki, Hiroko Koyama, Yuji Yoshiike, Hachiro Sugimoto, Yasuo Ihara, Akihiko Takashima

NATURE COMMUNICATIONS 6 10216 2015年12月査読有り
I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway.

Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H

Human molecular genetics 24(17) 4879-4900 2015年9月査読有り
Toxic Tau Aggregation in AD

Akihiko Takashima

Advances in Experimental Medicine and Biology 822 3-9 2015年査読有り
Female Hippocampus Vulnerability to Environmental Stress, a Precipitating Factor in Tau Aggregation Pathology

Ioannis Sotiropoulos, Joana Silva, Tetsuya Kimura, Ana Joao Rodrigues, Patricio Costa, Osborne F. X. Almeida, Nuno Sousa, Akihiko Takashima

JOURNAL OF ALZHEIMERS DISEASE 43(3) 763-774 2015年査読有り
tau-Tgマウス脳における内在性および外来性タウの神経細胞内局在

久保厚子, 御園生裕明, 松山誠, 高島明彦, 井原康夫, 宮坂知宏

Dementia Japan 28(4) 472-472 2014年10月査読有り
Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

Tomohiro Umeda, Satomi Maekawa, Tetsuya Kimura, Akihiko Takashima, Takami Tomiyama, Hiroshi Mori

ACTA NEUROPATHOLOGICA 127(5) 685-698 2014年5月査読有り
Development of disease modifying drugs for dementia-focusing on anti-tau drugs

Yoshiyuki Soeda, Akihiko Takashima

Clinical Neurology 54(12) 1178-1180 2014年査読有り
Microtubule-associated protein tau is essential for long-term depression in the hippocampus

Tetsuya Kimura, Daniel J. Whitcomb, Jihoon Jo, Philip Regan, Thomas Piers, Seonghoo Heo, Christopher Brown, Tsutomu Hashikawa, Miyuki Murayama, Heon Seok, Ioannis Sotiropoulos, Eunjoon Kim, Graham L. Collingridge, Akihiko Takashima, Kwangwook Cho

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 369(1633) 20130144 2014年1月査読有り
Biochemical distribution of tau protein in synaptosomal fraction of transgenic mice expressing human P301L tau

Naruhiko Sahara, Miyuki Murayama, Makoto Higuchi, Tetsuya Suhara, Akihiko Takashima

FRONTIERS IN NEUROLOGY 5 26 2014年査読有り
Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in mice heterozygously deficient for GSK-3β.

Arioka M, Takahashi-Yanaga F, Sasaki M, Yoshihara T, Morimoto S, Takashima A, Mori Y, Sasaguri T

Biochemical and biophysical research communications 440(4) 677-682 2013年11月1日査読有り
Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

Masahiro Maruyama, Hitoshi Shimada, Tetsuya Suhara, Hitoshi Shinotoh, Bin Ji, Jun Maeda, Ming-Rong Zhang, John Q. Trojanowski, Virginia M. -Y. Lee, Maiko Ono, Kazuto Masamoto, Harumasa Takano, Naruhiko Sahara, Nobuhisa Iwata, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Qing Chang, Takaomi C. Saido, Akihiko Takashima, Jada Lewis, Ming-Kuei Jang, Ichio Aoki, Hiroshi Ito, Makoto Higuchi

NEURON 79(6) 1094-1108 2013年9月査読有り
Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice.

Umeda T, Yamashita T, Kimura T, Ohnishi K, Takuma H, Ozeki T, Takashima A, Tomiyama T, Mori H

The American journal of pathology 183(1) 211-225 2013年7月査読有り
Present and future of the Tau dementia therapy

Akihiko Takashima

Clinical Neurology 53(11) 1040-1042 2013年査読有り
Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding.

Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki J, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M

The Journal of biological chemistry 287(18) 14631-14643 2012年4月査読有り
Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes

Yuji Yoshiike, Shunji Yamashita, Tatsuya Mizoroki, Sumihiro Maeda, Miyuki Murayama, Tetsuya Kimura, Naruhiko Sahara, Yoshiyuki Soeda, Akihiko Takashima

AGING CELL 11(1) 51-62 2012年2月査読有り
オートファジーに注目したLRRK2の生理機能

高島明彦

Neurodegener Dis. 10(1-4) 238-241 2012年査読有り
Binding of Curcumin to Senile Plaques and Cerebral Amyloid Angiopathy in the Aged Brain of Various Animals and to Neurofibrillary Tangles in Alzheimer's Brain

Mayu Mutsuga, James Kenn Chambers, Kazuyuki Uchida, Meina Tei, Takao Makibuchi, Tatsuya Mizorogi, Akihiko Takashima, Hiroyuki Nakayama

JOURNAL OF VETERINARY MEDICAL SCIENCE 74(1) 51-57 2012年1月査読有り
Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice

Taiki Kambe, Yumiko Motoi, Ran Inoue, Nobuhiko Kojima, Norihiro Tada, Tetsuya Kimura, Naruhiko Sahara, Shunji Yamashita, Tatsuya Mizoroki, Akihiko Takashima, Kohei Shimada, Koichi Ishiguro, Hiroshi Mizuma, Hirotaka Onoe, Yoshikuni Mizuno, Nobutaka Hattori

NEUROBIOLOGY OF DISEASE 42(3) 404-414 2011年6月査読有り
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction

Akira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu, Yosuke Hirotsu, Makiko Ohtsuji, Fumiki Katsuoka, Masayuki Yamamoto

GENES TO CELLS 16(6) 692-703 2011年6月査読有り
Stress Acts Cumulatively To Precipitate Alzheimer's Disease-Like Tau Pathology and Cognitive Deficits

Ioannis Sotiropoulos, Caterina Catania, Lucilia G. Pinto, Rui Silva, G. Elizabeth Pollerberg, Akihiko Takashima, Nuno Sousa, Osborne F. X. Almeida

JOURNAL OF NEUROSCIENCE 31(21) 7840-7847 2011年5月査読有り
Vitamin A has anti-oligomerization effects on amyloid-β in vitro.

Takasaki J, Ono K, Yoshiike Y, Hirohata M, Ikeda T, Morinaga A, Takashima A, Yamada M

Journal of Alzheimer's disease : JAD 27(2) 271-280 2011年査読有り
Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss

Tetsuya Kimura, Tetsuya Fukuda, Naruhiko Sahara, Shunji Yamashita, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Boyoung Lee, Ioannis Sotiropoulos, Sumihiro Maeda, Akihiko Takashima

Journal of Biological Chemistry 285(49) 38692-38699 2010年12月3日査読有り
Tau aggregation is a therapeutic target for Alzheimer's disease

Akihiko Takashima

Curr Alzheimer Res. 7(8) 665-669 2010年12月査読有り
Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function

Erica Peethumnongsin, Li Yang, Verena Kallhoff-Muñoz, Lingyun Hu, Akihiko Takashima, Robia G. Pautler, Hui Zheng

Journal of Neuroscience 30(40) 13409-13418 2010年10月6日査読有り
Drug development for tauopathy and Alzheimer's disease

Akihiko Takashima

Japanese Journal of Neuropsychopharmacology 30(4) 177-180 2010年8月査読有り
Significance of tau in the development of Alzheimer disease

Akihiko Takashima

Brain and Nerve 62(7) 701-708 2010年7月査読有り
Microtubule destruction induces tau liberation and its subsequent phosphorylation

Tomohiro Miyasaka, Sinji Sato, Yoshitaka Tatebayashi, Akihiko Takashima

FEBS LETTERS 584(14) 3227-3232 2010年7月
Promotion of CHIP-Mediated p53 Degradation Protects the Heart From Ischemic Injury

Atsuhiko T. Naito, Sho Okada, Tohru Minamino, Koji Iwanaga, Mei-Lan Liu, Tomokazu Sumida, Seitaro Nomura, Naruhiko Sahara, Tatsuya Mizoroki, Akihiko Takashima, Hiroshi Akazawa, Toshio Nagai, Ichiro Shiojima, Issei Komuro

CIRCULATION RESEARCH 106(11) 1692-U69 2010年6月査読有り
Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain

Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashima

NeuroToxicology 30(6) 1000-1007 2009年11月査読有り
A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid β proteins in vitro and in vivo

Hironori Fujiwara, Masahiro Tabuchi, Takuji Yamaguchi, Koh Iwasaki, Katsutoshi Furukawa, Kyoji Sekiguchi, Yasushi Ikarashi, Yukitsuka Kudo, Makoto Higuchi, Takaomi C. Saido, Sumihiro Maeda, Akihiko Takashima, Masahiko Hara, Nobuo Yaegashi, Yoshio Kase, Hiroyuki Arai

Journal of Neurochemistry 109(6) 1648-1657 2009年6月査読有り
Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency

Naohito Kitamura, Runa Araya, Moeko Kudoh, Haruo Kishida, Tetsuya Kimura, Miyuki Murayama, Akihiko Takashima, Yuriko Sakamaki, Tsutomu Hashikawa, Shingo Ito, Sumio Ohtsuki, Tetsuya Terasaki, Jürgen Wess, Masahisa Yamada

PLoS ONE 4(4) 2009年4月9日査読有り
O-Mannosylation is required for the solubilization of heterologously expressed human β-amyloid precursor protein in Saccharomyces cerevisiae

Akiko Murakami-Sekimata, Ken Sato, Ken Sato, Akihiko Takashima, Akihiko Nakano

Genes to Cells 14(2) 205-215 2009年査読有り
Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons

Masatake Fujimura, Fusako Usuki, Masumi Sawada, William Rostene, David Godefroy, Akihiko Takashima

NeuroToxicology 30(1) 16-22 2009年1月査読有り
Tau oligomerization: A role for tau aggregation intermediates linked to neurodegeneration

N. Sahara, S. Maeda, A. Takashima

Current Alzheimer Research 5(6) 591-598 2008年12月査読有り招待有り
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo

Emmanuel Planel, Pavan Krishnamurthy, Tomohiro Miyasaka, Li Liu, Mathieu Herman, Asok Kumar, Alexis Bretteville, Helen Y. Figueroa, Haung Yu Wai, Robert A. Whittington, Peter Davies, Akihiko Takashima, Ralph A. Nixon, Karen E. Duff

Journal of Neuroscience 28(48) 12798-12807 2008年11月26日査読有り
GSK-3β is required for memory reconsolidation in adult brain

Tetsuya Kimura, Shunji Yamashita, Shinobu Nakao, Jung-Mi Park, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Naruhiko Sahara, Akihiko Takashima

PLoS ONE 3(10) e3540 2008年10月28日査読有り
Amyloid oligomer conformation in a group of natively folded proteins

Yuji Yoshiike, Ryoichi Minai, Yo Matsuo, Yun-Ru Chen, Tetsuya Kimura, Akihiko Takashima

PLoS ONE 3(9) 2008年9月18日査読有り
GABA(A) Receptor-Mediated Acceleration of Aging-Associated Memory Decline in APP/PS1 Mice and Its Pharmacological Treatment by Picrotoxin

Yuji Yoshiike, Tetsuya Kimura, Shunji Yamashita, Hiroyuki Furudate, Tatsuya Mizoroki, Miyuki Murayama, Akihiko Takashima

PLOS ONE 3(8) 2008年8月査読有り
Complementary distributions of amyloid-β and neprilysin in the brains of dogs and cats

Y. Takeuchi, K. Uetsuka, M. Murayama, F. Kikuta, A. Takashima, K. Doi, H. Nakayama

Veterinary Pathology 45(4) 455-466 2008年7月査読有り
Active c-jun N-terminal kinase induces caspase cleavage of tau and additional phosphorylation by GSK-3β is required for tau aggregation

Naruhiko Sahara, Miyuki Murayama, Boyoung Lee, Jung-Mi Park, Sarita Lagalwar, Lester I. Binder, Akihiko Takashima

European Journal of Neuroscience 27(11) 2897-2906 2008年6月査読有り
Hyperphosphorylated tau is a cause of neuronal dysfunction in tauopathy

Akihiko Takashima

JOURNAL OF ALZHEIMERS DISEASE 14(4) 371-375 2008年査読有り
Enzymatic Characteristics of I213T Mutant Presenilin-1/γ-secretase in Cell Models and Knock-in Mouse Brains: FAD-linked Mutation Impairsγ-site Cleavage of APP-CTFβ

Masafumi Shimojo, Naruhiko Sahara, Tatsuya Mizoroki, Satoru Funamoto, Maho Morishima-Kawashima, Takashi Kudo, Masatoshi Takeda, Yasuo Ihara, Hiroshi Ichinose, Akihiko Takashima

J. Biol. Chem 2008年1月査読有り
Enzymatic Characteristics of I213T Mutant Presenilin-1/-Secretase in Cell Models and Knock-in Mouse Brains FAMILIAL ALZHEIMER DISEASE-LINKED MUTATION IMPAIRS-SITE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN C-TERMINAL FRAGMENT

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A

J. Biol. Chem. 283 16488-16496 2008年査読有り
Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau

Tetsuya Kimura, Shunji Yamashita, Tetsuya Fukuda, Jun-Mi Park, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Naruhiko Sahara, Akihiko Takashima

EMBO Journal 26(24) 5143-5152 2007年12月12日査読有り
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms

Emmanuel Planel, Yoshitaka Tatebayashi, Tomohiro Miyasaka, Li Liu, Lili Wang, Mathieu Herman, W. Haung Yu, Jose A. Luchsinger, Brian Wadzinski, Karen E. Duff, Akihiko Takashima

JOURNAL OF NEUROSCIENCE 27(50) 13635-13648 2007年12月

MISC

乳由来ペプチドのβラクトリンはアストロサイトのROS産生およびドーパミン分解を抑制する

阿野泰久, 秋山栞里, 綾部達宏, 大屋怜奈, 高島明彦

日本栄養・食糧学会大会講演要旨集 76th 2022年
タウ・バイオロジータウ凝集体の役割と凝集阻害剤開発

添田義行, 高島明彦

月刊細胞 53(1) 2021年
Immunohistochemical detection of phosphorylated alpha-synuclein in the brain of a tauopathy model, rTg4510 mice

Yuta Takaichi, Yasuhisa Ano, James Ken Chambers, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayama

BRAIN PATHOLOGY 29 79-79 2019年2月
植物由来抽出物を使ったタウ凝集阻害剤のスクリーニング

阿部将志, 添田義之, 楊金緯, 立崎仁, 高島明彦

Dementia Japan 33(4) 2019年
一分子イメージングによるヒトiPSC由来神経におけるタウタンパク質減少効果の確認

前田純宏, 坂内博子, 坂内博子, 高島明彦, 周智, 岡野栄之

Dementia Japan 33(4) 2019年

もっとみる

所属学協会

共同研究・競争的資金等の研究課題

神経変性疾患におけるシンギュラリティ現象の解析と分子機構の解明

日本学術振興会科学研究費助成事業 2018年6月 - 2023年3月

坂内博子, 高島明彦, 廣島通夫, 松本弦, 松田恵子
タウのタンパク質老化と毒性機序

日本学術振興会科学研究費助成事業 2014年7月 - 2019年3月

高島明彦, 久永眞市, 石垣診祐, 宮坂知宏, 池川雅哉, 添田義行, 住岡暁夫, 御園生裕明, 田口明子

一覧へ戻る

高島 明彦

基本情報

研究キーワード

研究分野

学歴

論文

MISC

所属学協会

共同研究・競争的資金等の研究課題

高島明彦