高島明彦

タカシマアキヒコ (Akihiko Takashima)

基本情報

所属: 学習院大学理学部生命科学科教授

学位: 理学博士

J-GLOBAL ID: 200901009923564735
researchmap会員ID: 5000101447

研究キーワード

研究分野

ライフサイエンス / 神経科学一般 /

学歴

- 1981年3月

九州大学大学院
- 1979年3月

九州大学理学部生物学科

論文

189

Familial Alzheimer's disease-associated mutations block translocation of full-length presenilin 1 to the nuclear envelope

Toshiyuki Honda, Naomi Nihonmatsu, Kaori Yasutake, Atsuko Ohtake, Kazuki Sato, Shoji Tanaka, Ohoshi Murayama, Miyuki Murayama, Akihiko Takashima

Neuroscience Research 37(2) 101-111 2000年6月査読有り
Proteolytic processing and degradation of human presenilin-1 expressed in yeast

Schaochuen Song, Masayuki Ohba, Yuko Saito, Toshiyuki Honda, Akihiko Takashima, Hiroshi Takahashi

Neuroscience Letters 282(1-2) 65-68 2000年3月17日査読有り
Twenty-nine missense mutations linked with familial Alzheimer's disease alter the processing of presenilin 1

Ohoshi Murayama, Miyuki Murayama, Toshiyuki Honda, Xiaoyan Sun, Naomi Nihonmatsu, Akihiko Takashima

Progress in Neuro-Psychopharmacology and Biological Psychiatry 23(5) 905-913 1999年7月査読有り
Enhancement of amyloid β 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease

Ohoshi Murayama, Taisuke Tomita, Naomi Nihonmatsu, Miyuki Murayama, Xiaoyan Sun, Toshiyuki Honda, Takeshi Iwatsubo, Akihiko Takashima

Neuroscience Letters 265(1) 61-63 1999年4月9日査読有り
Impaired proteolytic processing of presenilin-1 in chromosome 14-linked familial Alzheimer's disease patient lymphocytes

Hiroshi Takahashi, Marc Mercken, Toshiyuki Honda, Yuko Saito, Miyuki Murayama, Schaochuen Song, Akihiko Takashima

Neuroscience Letters 260(2) 121-124 1999年1月29日査読有り
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

Taiichi Katayama, Kazunori Imaizumi, Naoya Sato, Ko Miyoshi, Takashi Kudo, Junichi Hitomi, Takashi Morihara, Takunari Yoneda, Fumi Gomi, Yasutake Mori, Yuka Nakano, Junji Takeda, Takehide Tsuda, Yasuto Itoyama, Ohoshi Murayama, Akihiko Takashima, Peter St. George-Hyslop, Masatoshi Takeda, Masaya Tohyama

Nature Cell Biology 1(8) 479-485 1999年査読有り
Development of Alzheimer's disease through presenilin

A. Takashima

Seikagaku 71(11) 1331-1336 1999年査読有り
Dual roles of proteasome in the metabolism of Presenilin 1

Toshiyuki Honda, Kaori Yasutake, Naomi Nihonmatsu, Mark Mercken, Hiroshi Takahashi, Ohoshi Murayama, Miyuki Murayama, Kazuki Sato, Akira Omori, Satoshi Tsubuki, Takaomi C. Saido, Akihiko Takashima

Journal of Neurochemistry 72(1) 255-261 1999年査読有り
The dendritic translocation of translin protein in the form of BC1 RNA protein particles in developing rat hippocampal neurons in primary culture

Shunsuke Kobayashi, Akihiko Takashima, Kaijiro Anzai

Biochemical and Biophysical Research Communications 253(2) 448-453 1998年12月18日査読有り
Direct association of presenilin-1 with β-catenin

Miyuki Murayama, Shoji Tanaka, James Palacino, Ohoshi Murayama, Toshiyuki Honda, Xiaoyan Sun, Kaori Yasutake, Naomi Nihonmatsu, Benjamin Wolozin, Akihiko Takashima

FEBS Letters 433(1-2) 73-77 1998年8月14日査読有り
Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau

Akihiko Takashima, Miyuki Murayama, Ohoshi Murayama, Toshiyuki Kohno, Toshiyuki Honda, Kaori Yasutake, Naomi Nihonmatsu, Marc Mercken, Haruyasu Yamaguchi, Shiro Sugihara, Benjamin Wolozin

Proceedings of the National Academy of Sciences of the United States of America 95(16) 9637-9641 1998年8月4日査読有り
Activation of tau protein kinase I/glycogen synthase kinase-3β by amyloid β peptide (25-35) enhances phosphorylation of tau in hippocampal neurons

Akihiko Takashima, Toshiyuki Honda, Kaori Yasutake, Gilles Michel, Ohosi Murayama, Miyuki Murayama, Koichi Ishiguro, Haruyasu Yamaguchi

Neuroscience Research 31(4) 317-323 1998年8月査読有り
Characterization of human presenilin 1 transgenic rats: Increased sensitivity to apoptosis in primary neuronal cultures

C. Czech, M. Lesort, G. Tremp, F. Terro, V. Blanchard, B. Schombert, N. Carpentier, S. Dreisler, B. Bonici, A. Takashima, S. Moussaoui, J. Hugon, L. Pradier

Neuroscience 87(2) 325-336 1998年7月20日査読有り
Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells

Gilles Michel, Marc Mercken, Miyuki Murayama, Kaori Noguchi, Koichi Ishiguro, Kazutomo Imahori, Akihiko Takashima

Biochimica et Biophysica Acta - General Subjects 1380(2) 177-182 1998年4月10日査読有り
Possible role of tau protein kinases in pathogenesis of Alzheimer's disease

K. Imahori, M. Hoshi, K. Ishiguro, K. Sato, M. Takahashi, R. Shiurba, H. Yamaguchi, A. Takashima, T. Uchida

Neurobiology of Aging 19(1) S93-S98 1998年1月査読有り
Cloning of cDNA and expression of the gene encoding rat presenilin-2

Hiroshi Takahashi, Marc Mercken, Yuko Nakazato, Kaori Noguchi, Miyuki Murayama, Kazutomo Imahori, Akihiko Takashima

Gene 197(1-2) 383-387 1997年9月15日査読有り
Different effects of Alzheimer-associated mutations of presenilin 1 on its processing

Ohoshi Murayama, Toshiyuki Honda, Marc Mercken, Miyuki Murayama, Kaori Yasutake, Naomi Nihonmatsu, Yuko Nakazato, Gilles Michel, Shaochuen Song, Kazuki Sato, Hiroshi Takahashi, Akihiko Takashima

Neuroscience Letters 229(1) 61-64 1997年6月20日査読有り
Activation of LA-N-2 cell phospholipases by single alanine substitution analogs of amyloid β peptide (25-35)

I. N. Singh, K. Sato, A. Takashima, J. N. Kanfer

FEBS Letters 405(1) 65-67 1997年3月17日査読有り
Presenilin 1 Immunostaining Using Well-Characterized Antibodies in Human Tissues

T. Yamada, A. Takashima

Experimental Neurology 148(1) 10-12 1997年査読有り
Nontoxic amyloid β peptide1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease

Minako Hoshi, Akihiko Takashima, Miyuki Murayama, Kaori Yasutake, Natsuko Yoshida, Koichi Ishiguro, Toshimitsu Hoshino, Kazutomo Imahori

Journal of Biological Chemistry 272(4) 2038-2041 1997年査読有り
5-Azacytidine induces toxicity in PC12 cells by apoptosis

Mokbul M.D. Hossain, Akihiko Takashima, Hiroyuki Nakayama, Kunio Doi

Experimental and Toxicologic Pathology 49(3-4) 201-206 1997年査読有り
Three-dimensional structures of the amyloid β peptide (25-35) in membrane-mimicking environment

Toshiyuki Kohno, Kuniko Kobayashi, Tadakazu Maeda, Kazuki Sato, Akihiko Takashima

Biochemistry 35(50) 16094-16104 1996年12月17日査読有り
Localization of Alzheimer-associated presenilin 1 in transfected COS-7 cells

Akihiko Takashima, Michio Sato, Marc Mercken, Shouji Tanaka, Shunzo Kondo, Toshiyuki Honda, Kazuki Sato, Miyuki Murayama, Kaori Noguchi, Yuko Nakazato, Hiroshi Takahashi

Biochemical and Biophysical Research Communications 227(2) 423-426 1996年10月14日査読有り
Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component of TPK II

Haruyasu Yamaguchi, Koichi Ishiguro, Tsuneko Uchida, Akihiko Takashima, Cynthia A. Lemere, Kazutomo Imahori

Acta Neuropathologica 92(3) 232-241 1996年9月査読有り
Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing

Marc Mercken, Hiroshi Takahashi, Toshiyuki Honda, Kazuki Sato, Miyuki Murayama, Yuko Nakazato, Kaori Noguchi, Kasutomo Imahori, Akihiko Takashima

FEBS Letters 389(3) 297-303 1996年7月8日査読有り
Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3β in brain

Minako Hoshi, Akihiko Takashima, Kaori Noguchi, Miyuki Murayama, Michio Sato, Shunzo Kondo, Yoshito Saitoh, Koichi Ishiguro, Toshimitsu Hoshino, Kazutomo Imahori

Proceedings of the National Academy of Sciences of the United States of America 93(7) 2719-2723 1996年4月2日査読有り
Molecular cloning and expression of the rat homologue of presenilin-1

Hiroshi Takahashi, Miyuki Murayama, Akihiko Takashima, Marc Mercken, Yuko Nakazato, Kaori Noguchi, Kazutomo Imahori

Neuroscience Letters 206(2-3) 113-116 1996年3月15日査読有り
Exposure of rat hippocampal neurons to amyloid β peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β

Akihiko Takashima, Kaori Noguchi, Gilles Michel, Marc Mercken, Minako Hoshi, Koichi Ishiguro, Kazutomo Imahori

Neuroscience Letters 203(1) 33-36 1996年1月12日査読有り
Amyloid β peptide induces cytoplasmic accumulation of amyloid protein precursor via tau protein kinase I/glycogen synthase kinase-3β in rat hippocampal neurons

Akihiko Takashima, Haruyasu Yamaguchi, Kaori Noguchi, Gilles Michel, Koichi Ishiguro, Kazuki Sato, Toshimitu Hoshino, Minako Hoshi, Kazutomo Imahori

Neuroscience Letters 198(2) 83-86 1995年9月29日査読有り
Correlation among secondary structure, amyloid precursor protein accumulation, and neurotoxicity of amyloid β(25-35) peptide as analyzed by single alanine substitution

Kazuki Sato, Akiko Wakamiya, Tadakazu Maeda, Kaori Noguchi, Akihiko Takashima, Kazutomo Imahori

Journal of Biochemistry 118(6) 1108-1111 1995年査読有り
Immunohistochemical analysis of COOH-termini of amyloid beta protein (aβ using end-specific antisera for aβ40 and aβ42 in Alzheimer's disease and normal aging

Haruyasu Yamaguchi, Shiro Sugihara, Koji Ishiguro, Akihiko Takashima, Shunsaku Hirai

Amyloid 2(1) 7-16 1995年査読有り
Different localization of tau protein kinase I/Glycogen synthase kinase-3β from glycogen synthase kinase-3α in cerebellum mitochondria

Minako Hoshi, Michio Sato, Shunzo Kondo, Akihiko Takashima, Kaori Noguchi, Miho Takahashi, Koichi Ishiguro, Kazutomo Imahori

Journal of Biochemistry 118(4) 683-685 1995年査読有り
Regulation of muscarinic stimulation of norepinephrine release and PI hydrolysis during cell growth in PC12 cells

Akihiko Takashima, James G. Kenimer

Neuroscience Letters 153(1) 77-79 1993年4月16日査読有り
L‐Type Calcium Channel Regulates Depolarization‐Induced Survival of Rat Superior Cervical Ganglion Cells In Vitro

T. KOIKE, S. TANAKA, A. TAKASHIMA

Annals of the New York Academy of Sciences 707(1) 356-358 1993年査読有り
tau Protein kinase I is essential for amyloid β-protein-induced neurotoxicity

A. Takashima, K. Noguchi, K. Sato, T. Hoshino, K. Imahori

Proceedings of the National Academy of Sciences of the United States of America 90(16) 7789-7793 1993年査読有り
Nicardipine-sensitive enhancement of high K+-evoked dopamine release in PC12 cells pretreated with 12-O-tetradecanoylphorbol 13-acetate

Akihiko Takashima, Tatsuro Koike

BBA - Molecular Cell Research 930(2) 264-271 1987年9月14日査読有り
Cell Cycle‐Dependent Modulation of Biosynthesis and Stimulus‐Evoked Release of Catecholamines in PC12 Pheochromocytoma Cells

Tatsuro Koike, Akihiko Takashima

Journal of Neurochemistry 46(5) 1493-1500 1986年査読有り
Relationship between dopamine content and its secretion in PC12 cells as a function of cell growth

Akihiko Takashima, Tatsuro Koike

BBA - Molecular Cell Research 847(1) 101-107 1985年10月30日査読有り
Clonal Variability of PC12 Pheochromocytoma Cells with Respect to Catecholamine Biosynthesis

Tatsuro Koike, Akihiko Takashima

Journal of Neurochemistry 42(5) 1472-1475 1984年査読有り

MISC

乳由来ペプチドのβラクトリンはアストロサイトのROS産生およびドーパミン分解を抑制する

阿野泰久, 秋山栞里, 綾部達宏, 大屋怜奈, 高島明彦

日本栄養・食糧学会大会講演要旨集 76th 2022年
タウ・バイオロジータウ凝集体の役割と凝集阻害剤開発

添田義行, 高島明彦

月刊細胞 53(1) 2021年
Immunohistochemical detection of phosphorylated alpha-synuclein in the brain of a tauopathy model, rTg4510 mice

Yuta Takaichi, Yasuhisa Ano, James Ken Chambers, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayama

BRAIN PATHOLOGY 29 79-79 2019年2月
植物由来抽出物を使ったタウ凝集阻害剤のスクリーニング

阿部将志, 添田義之, 楊金緯, 立崎仁, 高島明彦

Dementia Japan 33(4) 2019年
一分子イメージングによるヒトiPSC由来神経におけるタウタンパク質減少効果の確認

前田純宏, 坂内博子, 坂内博子, 高島明彦, 周智, 岡野栄之

Dementia Japan 33(4) 2019年

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所属学協会

共同研究・競争的資金等の研究課題

神経変性疾患におけるシンギュラリティ現象の解析と分子機構の解明

日本学術振興会科学研究費助成事業 2018年6月 - 2023年3月

坂内博子, 高島明彦, 廣島通夫, 松本弦, 松田恵子
タウのタンパク質老化と毒性機序

日本学術振興会科学研究費助成事業 2014年7月 - 2019年3月

高島明彦, 久永眞市, 石垣診祐, 宮坂知宏, 池川雅哉, 添田義行, 住岡暁夫, 御園生裕明, 田口明子

一覧へ戻る

高島 明彦

基本情報

研究キーワード

研究分野

学歴

論文

MISC

所属学協会

共同研究・競争的資金等の研究課題

高島明彦