Akihiko Takashima

(高島明彦)

Profile Information

Affiliation: Faculty of Science Department of Life Science, Gakushuin University

Degree: 理学博士

J-GLOBAL ID: 200901009923564735
researchmap Member ID: 5000101447

Research Interests

Research Areas

Life sciences / Neuroscience - general /

Education

- Mar, 1981

九州大学大学院
- Mar, 1979

Department of Biology, School of Sciences, Kyushu University

Papers

189

Modification of Tau by 8-Nitroguanosine 3,5-Cyclic Monophosphate (8-Nitro-cGMP): EFFECTS OF NITRIC OXIDE-LINKED CHEMICAL MODIFICATION ON TAU AGGREGATION

Jun Yoshitake, Yoshiyuki Soeda, Tomoaki Ida, Akio Sumioka, Misato Yoshikawa, Kenji Matsushita, Takaaki Akaike, Akihiko Takashima

JOURNAL OF BIOLOGICAL CHEMISTRY, 291(43) 22714-22720, Oct, 2016 Peer-reviewed
Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Mikko T. Huuskonen, Sanna Loppi, Hiramani Dhungana, Velta Keksa-Goldsteine, Sighild Lemarchant, Paula Korhonen, Sara Wojciechowski, Eveliina Pollari, Piia Valonen, Juho Koponen, Akihiko Takashima, Gary Landreth, Gundars Goldsteins, Tarja Malm, Jari Koistinaho, Katja M. Kanninen

SCIENTIFIC REPORTS, 6 33176, Sep, 2016 Peer-reviewed
Assessment of pulp regeneration induced by stem cell therapy by magnetic resonance imaging

Koichiro Iohara, Masanori Fujita, Yoshiko Ariji, Misato Yoshikawa, Hideto Watanabe, Akihiko Takashima, Misako Nakashima

Journal of Endodontics, 42(3) 397-401, Mar 1, 2016 Peer-reviewed
The advantages of structural equation modeling to address the complexity of spatial reference learning

Pedro S. Moreira, Ioannis Sotiropoulos, Joana Silva, Akihiko Takashima, Nuno Sousa, Hugo Leite-Almeida, Patrício S. Costa

Frontiers in Behavioral Neuroscience, 10, Feb 26, 2016 Peer-reviewed
Glycogen Synthase Kinase 3 beta-mediated Phosphorylation in the Most C-terminal Region of Protein Interacting with C Kinase 1 (PICK1) Regulates the Binding of PICK1 to Glutamate Receptor Subunit GluA2

Sosuke Yagishita, Miyuki Murayama, Tomoe Ebihara, Kei Maruyama, Akihiko Takashima

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(49) 29438-29448, Dec, 2015 Peer-reviewed
Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

Yoshiyuki Soeda, Misato Yoshikawa, Osborne F. X. Almeida, Akio Sumioka, Sumihiro Maeda, Hiroyuki Osada, Yasumitsu Kondoh, Akiko Saito, Tomohiro Miyasaka, Tetsuya Kimura, Masaaki Suzuki, Hiroko Koyama, Yuji Yoshiike, Hachiro Sugimoto, Yasuo Ihara, Akihiko Takashima

NATURE COMMUNICATIONS, 6 10216, Dec, 2015 Peer-reviewed
I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3 beta signaling pathway

Etsuro Ohta, Tomoko Nihira, Akiko Uchino, Yoichi Imaizumi, Yohei Okada, Wado Akamatsu, Kayoko Takahashi, Hideki Hayakawa, Makiko Nagai, Manabu Ohyama, Masafuchi Ryo, Mieko Ogino, Shigeo Murayama, Akihiko Takashima, Kazutoshi Nishiyama, Yoshikuni Mizuno, Hideki Mochizuki, Fumiya Obata, Hideyuki Okano

HUMAN MOLECULAR GENETICS, 24(17) 4879-4900, Sep, 2015 Peer-reviewed
Toxic Tau Aggregation in AD

Akihiko Takashima

Advances in Experimental Medicine and Biology, 822 3-9, 2015 Peer-reviewed
Female Hippocampus Vulnerability to Environmental Stress, a Precipitating Factor in Tau Aggregation Pathology

Ioannis Sotiropoulos, Joana Silva, Tetsuya Kimura, Ana Joao Rodrigues, Patricio Costa, Osborne F. X. Almeida, Nuno Sousa, Akihiko Takashima

JOURNAL OF ALZHEIMERS DISEASE, 43(3) 763-774, 2015 Peer-reviewed
tau-Tgマウス脳における内在性および外来性タウの神経細胞内局在

久保厚子, 御園生裕明, 松山誠, 高島明彦, 井原康夫, 宮坂知宏

Dementia Japan, 28(4) 472-472, Oct, 2014 Peer-reviewed
Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

Tomohiro Umeda, Satomi Maekawa, Tetsuya Kimura, Akihiko Takashima, Takami Tomiyama, Hiroshi Mori

ACTA NEUROPATHOLOGICA, 127(5) 685-698, May, 2014 Peer-reviewed
Development of disease modifying drugs for dementia-focusing on anti-tau drugs

Yoshiyuki Soeda, Akihiko Takashima

Clinical Neurology, 54(12) 1178-1180, 2014 Peer-reviewed
Microtubule-associated protein tau is essential for long-term depression in the hippocampus

Tetsuya Kimura, Daniel J. Whitcomb, Jihoon Jo, Philip Regan, Thomas Piers, Seonghoo Heo, Christopher Brown, Tsutomu Hashikawa, Miyuki Murayama, Heon Seok, Ioannis Sotiropoulos, Eunjoon Kim, Graham L. Collingridge, Akihiko Takashima, Kwangwook Cho

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 369(1633) 20130144, Jan, 2014 Peer-reviewed
Biochemical distribution of tau protein in synaptosomal fraction of transgenic mice expressing human P301L tau

Naruhiko Sahara, Miyuki Murayama, Makoto Higuchi, Tetsuya Suhara, Akihiko Takashima

FRONTIERS IN NEUROLOGY, 5 26, 2014 Peer-reviewed
Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in mice heterozygously deficient for GSK-3β

Masaki Arioka, Fumi Takahashi-Yanaga, Masanori Sasaki, Tatsuya Yoshihara, Sachio Morimoto, Akihiko Takashima, Yoshihide Mori, Toshiyuki Sasaguri

Biochemical and Biophysical Research Communications, 440(4) 677-682, Nov 1, 2013 Peer-reviewed
Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

Masahiro Maruyama, Hitoshi Shimada, Tetsuya Suhara, Hitoshi Shinotoh, Bin Ji, Jun Maeda, Ming-Rong Zhang, John Q. Trojanowski, Virginia M. -Y. Lee, Maiko Ono, Kazuto Masamoto, Harumasa Takano, Naruhiko Sahara, Nobuhisa Iwata, Nobuyuki Okamura, Shozo Furumoto, Yukitsuka Kudo, Qing Chang, Takaomi C. Saido, Akihiko Takashima, Jada Lewis, Ming-Kuei Jang, Ichio Aoki, Hiroshi Ito, Makoto Higuchi

NEURON, 79(6) 1094-1108, Sep, 2013 Peer-reviewed
Neurodegenerative Disorder FTDP-17-Related Tau Intron 10+16 -> T Mutation Increases Tau Exon 10 Splicing and Causes Tauopathy in Transgenic Mice

Tomohiro Umeda, Takenari Yamashita, Tetsuya Kimura, Kiyouhisa Ohnishi, Hiroshi Takuma, Tomoko Ozeki, Akihiko Takashima, Takami Tomiyama, Hiroshi Mori

AMERICAN JOURNAL OF PATHOLOGY, 183(1) 211-225, Jul, 2013 Peer-reviewed
Present and future of the Tau dementia therapy

Akihiko Takashima

Clinical Neurology, 53(11) 1040-1042, 2013 Peer-reviewed
Phenolic Compounds Prevent Amyloid beta-Protein Oligomerization and Synaptic Dysfunction by Site-specific Binding

Kenjiro Ono, Lei Li, Yusaku Takamura, Yuji Yoshiike, Lijun Zhu, Fang Han, Xian Mao, Tokuhei Ikeda, Jun-ichi Takasaki, Hisao Nishijo, Akihiko Takashima, David B. Teplow, Michael G. Zagorski, Masahito Yamada

JOURNAL OF BIOLOGICAL CHEMISTRY, 287(18) 14631-14643, Apr, 2012 Peer-reviewed
Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes

Yuji Yoshiike, Shunji Yamashita, Tatsuya Mizoroki, Sumihiro Maeda, Miyuki Murayama, Tetsuya Kimura, Naruhiko Sahara, Yoshiyuki Soeda, Akihiko Takashima

AGING CELL, 11(1) 51-62, Feb, 2012 Peer-reviewed
Regulation of Physiologic Actions of LRRK2: Focus on Autophagy

Andrew Ferree, Maria Guillily, Hu Li, Katelyn Smith, Aki Takashima, Rachel Squillace, Manfred Weigele, James J. Collins, Benjamin Wolozin

NEURODEGENERATIVE DISEASES, 10(1-4) 238-241, 2012 Peer-reviewed
Binding of Curcumin to Senile Plaques and Cerebral Amyloid Angiopathy in the Aged Brain of Various Animals and to Neurofibrillary Tangles in Alzheimer's Brain

Mayu Mutsuga, James Kenn Chambers, Kazuyuki Uchida, Meina Tei, Takao Makibuchi, Tatsuya Mizorogi, Akihiko Takashima, Hiroyuki Nakayama

JOURNAL OF VETERINARY MEDICAL SCIENCE, 74(1) 51-57, Jan, 2012 Peer-reviewed
Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice

Taiki Kambe, Yumiko Motoi, Ran Inoue, Nobuhiko Kojima, Norihiro Tada, Tetsuya Kimura, Naruhiko Sahara, Shunji Yamashita, Tatsuya Mizoroki, Akihiko Takashima, Kohei Shimada, Koichi Ishiguro, Hiroshi Mizuma, Hirotaka Onoe, Yoshikuni Mizuno, Nobutaka Hattori

NEUROBIOLOGY OF DISEASE, 42(3) 404-414, Jun, 2011 Peer-reviewed
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction

Akira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu, Yosuke Hirotsu, Makiko Ohtsuji, Fumiki Katsuoka, Masayuki Yamamoto

GENES TO CELLS, 16(6) 692-703, Jun, 2011 Peer-reviewed
Stress Acts Cumulatively To Precipitate Alzheimer's Disease-Like Tau Pathology and Cognitive Deficits

Ioannis Sotiropoulos, Caterina Catania, Lucilia G. Pinto, Rui Silva, G. Elizabeth Pollerberg, Akihiko Takashima, Nuno Sousa, Osborne F. X. Almeida

JOURNAL OF NEUROSCIENCE, 31(21) 7840-7847, May, 2011 Peer-reviewed
Vitamin A has anti-oligomerization effects on amyloid-β in vitro

Junichi Takasaki, Kenjiro Ono, Yuji Yoshiike, Mie Hirohata, Tokuhei Ikeda, Akiyoshi Morinaga, Akihiko Takashima, Masahito Yamada

Journal of Alzheimer's Disease, 27(2) 271-280, 2011 Peer-reviewed
Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss

Tetsuya Kimura, Tetsuya Fukuda, Naruhiko Sahara, Shunji Yamashita, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Boyoung Lee, Ioannis Sotiropoulos, Sumihiro Maeda, Akihiko Takashima

Journal of Biological Chemistry, 285(49) 38692-38699, Dec 3, 2010 Peer-reviewed
Tau aggregation is a therapeutic target for Alzheimer's disease

Akihiko Takashima

Curr Alzheimer Res., 7(8) 665-669, Dec, 2010 Peer-reviewed
Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function

Erica Peethumnongsin, Li Yang, Verena Kallhoff-Muñoz, Lingyun Hu, Akihiko Takashima, Robia G. Pautler, Hui Zheng

Journal of Neuroscience, 30(40) 13409-13418, Oct 6, 2010 Peer-reviewed
Drug development for tauopathy and Alzheimer's disease

Akihiko Takashima

Japanese Journal of Neuropsychopharmacology, 30(4) 177-180, Aug, 2010 Peer-reviewed
Significance of tau in the development of Alzheimer disease

Akihiko Takashima

Brain and Nerve, 62(7) 701-708, Jul, 2010 Peer-reviewed
Microtubule destruction induces tau liberation and its subsequent phosphorylation

Tomohiro Miyasaka, Sinji Sato, Yoshitaka Tatebayashi, Akihiko Takashima

FEBS LETTERS, 584(14) 3227-3232, Jul, 2010
Promotion of CHIP-Mediated p53 Degradation Protects the Heart From Ischemic Injury

Atsuhiko T. Naito, Sho Okada, Tohru Minamino, Koji Iwanaga, Mei-Lan Liu, Tomokazu Sumida, Seitaro Nomura, Naruhiko Sahara, Tatsuya Mizoroki, Akihiko Takashima, Hiroshi Akazawa, Toshio Nagai, Ichiro Shiojima, Issei Komuro

CIRCULATION RESEARCH, 106(11) 1692-U69, Jun, 2010 Peer-reviewed
Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain

Masatake Fujimura, Fusako Usuki, Masumi Sawada, Akihiko Takashima

NeuroToxicology, 30(6) 1000-1007, Nov, 2009 Peer-reviewed
A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid β proteins in vitro and in vivo

Hironori Fujiwara, Masahiro Tabuchi, Takuji Yamaguchi, Koh Iwasaki, Katsutoshi Furukawa, Kyoji Sekiguchi, Yasushi Ikarashi, Yukitsuka Kudo, Makoto Higuchi, Takaomi C. Saido, Sumihiro Maeda, Akihiko Takashima, Masahiko Hara, Nobuo Yaegashi, Yoshio Kase, Hiroyuki Arai

Journal of Neurochemistry, 109(6) 1648-1657, Jun, 2009 Peer-reviewed
Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency

Naohito Kitamura, Runa Araya, Moeko Kudoh, Haruo Kishida, Tetsuya Kimura, Miyuki Murayama, Akihiko Takashima, Yuriko Sakamaki, Tsutomu Hashikawa, Shingo Ito, Sumio Ohtsuki, Tetsuya Terasaki, Jürgen Wess, Masahisa Yamada

PLoS ONE, 4(4), Apr 9, 2009 Peer-reviewed
O-Mannosylation is required for the solubilization of heterologously expressed human β-amyloid precursor protein in Saccharomyces cerevisiae

Akiko Murakami-Sekimata, Ken Sato, Ken Sato, Akihiko Takashima, Akihiko Nakano

Genes to Cells, 14(2) 205-215, 2009 Peer-reviewed
Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons

Masatake Fujimura, Fusako Usuki, Masumi Sawada, William Rostene, David Godefroy, Akihiko Takashima

NeuroToxicology, 30(1) 16-22, Jan, 2009 Peer-reviewed
Tau oligomerization: A role for tau aggregation intermediates linked to neurodegeneration

N. Sahara, S. Maeda, A. Takashima

Current Alzheimer Research, 5(6) 591-598, Dec, 2008 Peer-reviewedInvited
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo

Emmanuel Planel, Pavan Krishnamurthy, Tomohiro Miyasaka, Li Liu, Mathieu Herman, Asok Kumar, Alexis Bretteville, Helen Y. Figueroa, Haung Yu Wai, Robert A. Whittington, Peter Davies, Akihiko Takashima, Ralph A. Nixon, Karen E. Duff

Journal of Neuroscience, 28(48) 12798-12807, Nov 26, 2008 Peer-reviewed
GSK-3β is required for memory reconsolidation in adult brain

Tetsuya Kimura, Shunji Yamashita, Shinobu Nakao, Jung-Mi Park, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Naruhiko Sahara, Akihiko Takashima

PLoS ONE, 3(10) e3540, Oct 28, 2008 Peer-reviewed
Amyloid oligomer conformation in a group of natively folded proteins

Yuji Yoshiike, Ryoichi Minai, Yo Matsuo, Yun-Ru Chen, Tetsuya Kimura, Akihiko Takashima

PLoS ONE, 3(9), Sep 18, 2008 Peer-reviewed
GABA(A) Receptor-Mediated Acceleration of Aging-Associated Memory Decline in APP/PS1 Mice and Its Pharmacological Treatment by Picrotoxin

Yuji Yoshiike, Tetsuya Kimura, Shunji Yamashita, Hiroyuki Furudate, Tatsuya Mizoroki, Miyuki Murayama, Akihiko Takashima

PLOS ONE, 3(8), Aug, 2008 Peer-reviewed
Complementary distributions of amyloid-β and neprilysin in the brains of dogs and cats

Y. Takeuchi, K. Uetsuka, M. Murayama, F. Kikuta, A. Takashima, K. Doi, H. Nakayama

Veterinary Pathology, 45(4) 455-466, Jul, 2008 Peer-reviewed
Active c-jun N-terminal kinase induces caspase cleavage of tau and additional phosphorylation by GSK-3β is required for tau aggregation

Naruhiko Sahara, Miyuki Murayama, Boyoung Lee, Jung-Mi Park, Sarita Lagalwar, Lester I. Binder, Akihiko Takashima

European Journal of Neuroscience, 27(11) 2897-2906, Jun, 2008 Peer-reviewed
Hyperphosphorylated tau is a cause of neuronal dysfunction in tauopathy

Akihiko Takashima

JOURNAL OF ALZHEIMERS DISEASE, 14(4) 371-375, 2008 Peer-reviewed
Enzymatic Characteristics of I213T Mutant Presenilin-1/γ-secretase in Cell Models and Knock-in Mouse Brains: FAD-linked Mutation Impairsγ-site Cleavage of APP-CTFβ

Masafumi Shimojo, Naruhiko Sahara, Tatsuya Mizoroki, Satoru Funamoto, Maho Morishima-Kawashima, Takashi Kudo, Masatoshi Takeda, Yasuo Ihara, Hiroshi Ichinose, Akihiko Takashima

J. Biol. Chem, Jan, 2008 Peer-reviewed
Enzymatic Characteristics of I213T Mutant Presenilin-1/-Secretase in Cell Models and Knock-in Mouse Brains FAMILIAL ALZHEIMER DISEASE-LINKED MUTATION IMPAIRS-SITE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN C-TERMINAL FRAGMENT

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A

J. Biol. Chem., 283 16488-16496, 2008 Peer-reviewed
Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau

Tetsuya Kimura, Shunji Yamashita, Tetsuya Fukuda, Jun-Mi Park, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Naruhiko Sahara, Akihiko Takashima

EMBO Journal, 26(24) 5143-5152, Dec 12, 2007 Peer-reviewed
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms

Emmanuel Planel, Yoshitaka Tatebayashi, Tomohiro Miyasaka, Li Liu, Lili Wang, Mathieu Herman, W. Haung Yu, Jose A. Luchsinger, Brian Wadzinski, Karen E. Duff, Akihiko Takashima

JOURNAL OF NEUROSCIENCE, 27(50) 13635-13648, Dec, 2007

Misc.

乳由来ペプチドのβラクトリンはアストロサイトのROS産生およびドーパミン分解を抑制する

阿野泰久, 秋山栞里, 綾部達宏, 大屋怜奈, 高島明彦

日本栄養・食糧学会大会講演要旨集, 76th, 2022
Role of tau aggregates and development of aggregation inhibitors

添田義行, 高島明彦

月刊細胞, 53(1), 2021
Immunohistochemical detection of phosphorylated alpha-synuclein in the brain of a tauopathy model, rTg4510 mice

Yuta Takaichi, Yasuhisa Ano, James Ken Chambers, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayama

BRAIN PATHOLOGY, 29 79-79, Feb, 2019
植物由来抽出物を使ったタウ凝集阻害剤のスクリーニング

阿部将志, 添田義之, 楊金緯, 立崎仁, 高島明彦

Dementia Japan, 33(4), 2019
一分子イメージングによるヒトiPSC由来神経におけるタウタンパク質減少効果の確認

前田純宏, 坂内博子, 坂内博子, 高島明彦, 周智, 岡野栄之

Dementia Japan, 33(4), 2019

Professional Memberships

Research Projects

Research on the molecular mechanism of singularity phenomenon in neurological disorders

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2023
Mechanism of tau protein aging and neurodegeneration

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Jul, 2014 - Mar, 2019

Takashima Akihiko, Soeda Yoshiyuki, Sumioka Akio, Misonou Hiroaki, Taguchi Akiko

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