Researcher Search Results Tatsuya Haga Tatsuya Haga (芳賀 達也) Please select the form format to download from below 「Education and research environment」format 「No. 4, the Ministry of Education document style ①Outline for Vitae」format 「No. 4, the Ministry of Education document style ②Education and research environment」format Profile Information AffiliationProfessor, Faculty of Science, Department of Chemistry, Biochemistry, Gakushuin UniversityDegreePh.D.(The University of Tokyo)(BLANK)(BLANK)J-GLOBAL ID200901090206888960researchmap Member ID1000011101External linkhttp://www.gakushuin.ac.jp/univ/sci/bio/main.html Research Interests 6 シグナル伝達 トランスポーター 受容体 Signal Transduction Transporter Receptor Research Areas 3 Life sciences / Medical biochemistry / Life sciences / Functional biochemistry / Life sciences / Neuroscience - general / Research History 6 1988 - 2001 Faculty of Medicine, The University of Tokyo 1988 - 2001 Professor, Faculty of Medicine, Tokyo Univ. 2001 - 学習院大学理学部 教授 2001 - Professor, Faculty of Science, Gaku shuin Univ 1974 - 1988 Faculty of Medicine, Hamamatsu University School of Medicine More Education 4 - 1970 The University of Tokyo - 1970 Graduate School, Division of Science, The University of Tokyo - 1963 Faculty of Science, The University of Tokyo - 1963 Faculty of Science, The University of Tokyo Committee Memberships 3 1991 - 1992 理事, 日本神経化学会 1988 評議員, 日本生化学会 評議員, 日本薬理学会 Awards 1 1987 斉藤賞 Misc. 77 SEQUESTRATION OF MUSCARINIC ACETYLCHOLINE-RECEPTOR M2 SUBTYPES - FACILITATION BY G-PROTEIN-COUPLED RECEPTOR KINASE (GRK2) AND ATTENUATION BY A DOMINANT-NEGATIVE MUTANT OF GRK2 H TSUGA, K KAMEYAMA, T HAGA, H KUROSE, T NAGAO JOURNAL OF BIOLOGICAL CHEMISTRY, 269(51) 32522-32527, Dec, 1994 G protein-coupled receptor kinases. J. Neurochem., 63,400-412, 1994 Solubilization of muscarinic receptor subtypes from baculovirus infected Sf9 insect cells. Biochem Pharmacol, 48,1245-1251, 1994 Location of agonist-dependent-phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype). Eur. J. Biochem., 220,29-36, 1994 Activation of a GTP-binding protein and a GTP-binding-protein-coupled receptor kinase(β-adenergic-receptor Kinase-1) by a muscarinic receptor m2 mutant lacking phosphorylation sites. Eur. J. Biochem., 226,267-276, 1994 Synergistic activation of a G protein-coupled receptor kinase by G protein βγ subunits and mastoparan or related peptides. J. Biol. Chem., 269,12594-12599, 1994 Solubilization and characterization of atrial muscarinic acetylcholine receptors in sucrose monolaurate. Arch. Biochem. Biophys., 301,158-164, 1993 Phosphorylation of muscarinic receptors : Regulation by G proteins. Life Sci., 52,421-428, 1993 Activation by G protein βγ subunits of β adrenergic and muscarinic receptor kinase. J. Biol. Chem., 268,7753-7758, 1993 Effects of magnesium ion on the interaction of atrial muscarinic acetylcholine receptors and GTP-binding regulatory proteins. Biochemistry, 31,10634-10642, 1992 Activation by G protein βγ subunits of agonist- or light-dependent phosphorylation of muscarinic acetylcholine receptors and rhodopsin J. Biol. Chem., 267,2222-2227, 1992 Location in muscarinic acetylcholine receptors of sites for [3H] propylbenzilylcholine mustard binding and for phosphorylation with protein kinase C. J. Neurochem., 54,1870-1811, 1990 Identification of two novel GTP-binding protein α-subunits that lack apparent ADP-ribosylation sites for pertussis toxin. J. Biol. Chem., 266,12676-12681, 1989 Effect of the lipid environment on the differential affinity of purified cerebral and atrial muscarinic acetylcholine receptors for pirenzepine. Mol. Pharmacol., 36,601-607, 1989 Molecular properties of muscarinic receptors. Trends. Pharmacol. Sci. Suppl, 12-18, 1988 Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence. FEBS Lett., 197,305-310, 1986 Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. J. Biol. Chem., 261,6423-6428, 1986 Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor Nature, 323,411-416, 1986 Reconstitution of the muscarinic acetylcholine receptor : guanine mucleotide-sensitive high affinity binding of agonist to purified muscarinic receptors reconstituted with GTP-binding proteins (Gi and Go) J. Biol. Chem., 261,10133-10140, 1986 Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature, 315,242-245, 1985 Purification of the muscarinic acetylcholine receptor from porcine brain J. Biol. Chem., 260,7927-7935, 1985 Affinity chromatography of the muscarinic acetylcholine receptor J. Biol. Chem., 258,13575-13579, 1983 Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells Proc. Natl. Acal. Sci., 74,2016-2020, 1977 Hydrodynamic properties of the β-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells J. Biol. Chem., 252,5776-5782, 1977 Microtubule formation from two components separated by gel filtration of a tubulin preparation Biochim. Biophys. Acta., 392,335-345, 1975 Choline uptake systems of rat brain synaptosomes Biochim. Biophys. Acta, 291,564-575, 1973 Synthesis and release of [14C]acetylcholine in synaptosomes J. Neurochem., 18,781-798, 1971 «12 Books and Other Publications 6 G Protein-Coupled Receptors Ed. by T. Hga and G. Berstein CRC. Press, 1999 Receptor Biochemistry. In : Encyclopedia of Molecular Biology and Molecular Medicine Medicine, Volume 5, edited by Meyers, R. A. Weiheim, New York, Basel, Cambridge, Tokyo : VCH, 1997 G protein-coupled receptor kinase : Phosphorylation of muscarinic receptors and facilitation of receptor sequestration. Advances in Pharmacology, Volume 36 : Intracellular Signal Transduction, edited by Hidaka, H. and Nairin, A. C. San Diego, New York, Boston, London, Sydney, Tokyo, Toronto : Academic Press, 1996 Phosphorylation and sequestration of muscarinic receptors. In : Molecular mechanisms of muscarinic acetylcholine receptor function R. G. Landrs Company, Biomedical Publishers Austin, Texas, 1995 Solubilization, purification, and molecular characterization of receptors : principles and strategy. In : Receptor biochemistry, A practical approach, edited by Hulme, E. C. Oxford : Oxford University Press, 1990 More Professional Memberships 7 日本薬理学会 米国神経科学会 国際神経化学会 日本神経科学協会 日本生物物理学会 More Research Projects 6 Gタンパク質共役受容体の新規リガンド検索 高親和性コリントランスポーターの構造と機能制御 基礎科学研究 神経伝達物質受容体の生化学 基礎科学研究 Screening of ligands for orphan GPCRs Structure and Regulation of High-affinity choline Transporter More Industrial Property Rights 4 表面プラズモン共鳴角及び蛍光同時検出装置 特願2000-250423 新規Gタンパク質共役受容体 特願2001-34434 髙親和性コリントランスポーター 特願平11-368991 ‐ PCT/JP00/05545
Tatsuya Haga (芳賀 達也) Please select the form format to download from below 「Education and research environment」format 「No. 4, the Ministry of Education document style ①Outline for Vitae」format 「No. 4, the Ministry of Education document style ②Education and research environment」format Profile Information AffiliationProfessor, Faculty of Science, Department of Chemistry, Biochemistry, Gakushuin UniversityDegreePh.D.(The University of Tokyo)(BLANK)(BLANK)J-GLOBAL ID200901090206888960researchmap Member ID1000011101External linkhttp://www.gakushuin.ac.jp/univ/sci/bio/main.html Research Interests 6 シグナル伝達 トランスポーター 受容体 Signal Transduction Transporter Receptor Research Areas 3 Life sciences / Medical biochemistry / Life sciences / Functional biochemistry / Life sciences / Neuroscience - general / Research History 6 1988 - 2001 Faculty of Medicine, The University of Tokyo 1988 - 2001 Professor, Faculty of Medicine, Tokyo Univ. 2001 - 学習院大学理学部 教授 2001 - Professor, Faculty of Science, Gaku shuin Univ 1974 - 1988 Faculty of Medicine, Hamamatsu University School of Medicine More Education 4 - 1970 The University of Tokyo - 1970 Graduate School, Division of Science, The University of Tokyo - 1963 Faculty of Science, The University of Tokyo - 1963 Faculty of Science, The University of Tokyo Committee Memberships 3 1991 - 1992 理事, 日本神経化学会 1988 評議員, 日本生化学会 評議員, 日本薬理学会 Awards 1 1987 斉藤賞 Misc. 77 SEQUESTRATION OF MUSCARINIC ACETYLCHOLINE-RECEPTOR M2 SUBTYPES - FACILITATION BY G-PROTEIN-COUPLED RECEPTOR KINASE (GRK2) AND ATTENUATION BY A DOMINANT-NEGATIVE MUTANT OF GRK2 H TSUGA, K KAMEYAMA, T HAGA, H KUROSE, T NAGAO JOURNAL OF BIOLOGICAL CHEMISTRY, 269(51) 32522-32527, Dec, 1994 G protein-coupled receptor kinases. J. Neurochem., 63,400-412, 1994 Solubilization of muscarinic receptor subtypes from baculovirus infected Sf9 insect cells. Biochem Pharmacol, 48,1245-1251, 1994 Location of agonist-dependent-phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype). Eur. J. Biochem., 220,29-36, 1994 Activation of a GTP-binding protein and a GTP-binding-protein-coupled receptor kinase(β-adenergic-receptor Kinase-1) by a muscarinic receptor m2 mutant lacking phosphorylation sites. Eur. J. Biochem., 226,267-276, 1994 Synergistic activation of a G protein-coupled receptor kinase by G protein βγ subunits and mastoparan or related peptides. J. Biol. Chem., 269,12594-12599, 1994 Solubilization and characterization of atrial muscarinic acetylcholine receptors in sucrose monolaurate. Arch. Biochem. Biophys., 301,158-164, 1993 Phosphorylation of muscarinic receptors : Regulation by G proteins. Life Sci., 52,421-428, 1993 Activation by G protein βγ subunits of β adrenergic and muscarinic receptor kinase. J. Biol. Chem., 268,7753-7758, 1993 Effects of magnesium ion on the interaction of atrial muscarinic acetylcholine receptors and GTP-binding regulatory proteins. Biochemistry, 31,10634-10642, 1992 Activation by G protein βγ subunits of agonist- or light-dependent phosphorylation of muscarinic acetylcholine receptors and rhodopsin J. Biol. Chem., 267,2222-2227, 1992 Location in muscarinic acetylcholine receptors of sites for [3H] propylbenzilylcholine mustard binding and for phosphorylation with protein kinase C. J. Neurochem., 54,1870-1811, 1990 Identification of two novel GTP-binding protein α-subunits that lack apparent ADP-ribosylation sites for pertussis toxin. J. Biol. Chem., 266,12676-12681, 1989 Effect of the lipid environment on the differential affinity of purified cerebral and atrial muscarinic acetylcholine receptors for pirenzepine. Mol. Pharmacol., 36,601-607, 1989 Molecular properties of muscarinic receptors. Trends. Pharmacol. Sci. Suppl, 12-18, 1988 Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence. FEBS Lett., 197,305-310, 1986 Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. J. Biol. Chem., 261,6423-6428, 1986 Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor Nature, 323,411-416, 1986 Reconstitution of the muscarinic acetylcholine receptor : guanine mucleotide-sensitive high affinity binding of agonist to purified muscarinic receptors reconstituted with GTP-binding proteins (Gi and Go) J. Biol. Chem., 261,10133-10140, 1986 Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature, 315,242-245, 1985 Purification of the muscarinic acetylcholine receptor from porcine brain J. Biol. Chem., 260,7927-7935, 1985 Affinity chromatography of the muscarinic acetylcholine receptor J. Biol. Chem., 258,13575-13579, 1983 Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells Proc. Natl. Acal. Sci., 74,2016-2020, 1977 Hydrodynamic properties of the β-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells J. Biol. Chem., 252,5776-5782, 1977 Microtubule formation from two components separated by gel filtration of a tubulin preparation Biochim. Biophys. Acta., 392,335-345, 1975 Choline uptake systems of rat brain synaptosomes Biochim. Biophys. Acta, 291,564-575, 1973 Synthesis and release of [14C]acetylcholine in synaptosomes J. Neurochem., 18,781-798, 1971 «12 Books and Other Publications 6 G Protein-Coupled Receptors Ed. by T. Hga and G. Berstein CRC. Press, 1999 Receptor Biochemistry. In : Encyclopedia of Molecular Biology and Molecular Medicine Medicine, Volume 5, edited by Meyers, R. A. Weiheim, New York, Basel, Cambridge, Tokyo : VCH, 1997 G protein-coupled receptor kinase : Phosphorylation of muscarinic receptors and facilitation of receptor sequestration. Advances in Pharmacology, Volume 36 : Intracellular Signal Transduction, edited by Hidaka, H. and Nairin, A. C. San Diego, New York, Boston, London, Sydney, Tokyo, Toronto : Academic Press, 1996 Phosphorylation and sequestration of muscarinic receptors. In : Molecular mechanisms of muscarinic acetylcholine receptor function R. G. Landrs Company, Biomedical Publishers Austin, Texas, 1995 Solubilization, purification, and molecular characterization of receptors : principles and strategy. In : Receptor biochemistry, A practical approach, edited by Hulme, E. C. Oxford : Oxford University Press, 1990 More Professional Memberships 7 日本薬理学会 米国神経科学会 国際神経化学会 日本神経科学協会 日本生物物理学会 More Research Projects 6 Gタンパク質共役受容体の新規リガンド検索 高親和性コリントランスポーターの構造と機能制御 基礎科学研究 神経伝達物質受容体の生化学 基礎科学研究 Screening of ligands for orphan GPCRs Structure and Regulation of High-affinity choline Transporter More Industrial Property Rights 4 表面プラズモン共鳴角及び蛍光同時検出装置 特願2000-250423 新規Gタンパク質共役受容体 特願2001-34434 髙親和性コリントランスポーター 特願平11-368991 ‐ PCT/JP00/05545