Tatsuya Haga

(芳賀達也)

Profile Information

Affiliation: Professor, Faculty of Science, Department of Chemistry, Biochemistry, Gakushuin University

Degree: Ph.D.(The University of Tokyo)
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J-GLOBAL ID: 200901090206888960
researchmap Member ID: 1000011101

External link: http://www.gakushuin.ac.jp/univ/sci/bio/main.html

Research Interests

Research Areas

Research History

1988 - 2001

Faculty of Medicine, The University of Tokyo
1988 - 2001

Professor, Faculty of Medicine, Tokyo Univ.
2001

- 学習院大学理学部教授
2001

- Professor, Faculty of Science, Gaku shuin Univ
1974 - 1988

Faculty of Medicine, Hamamatsu University School of Medicine

Education

- 1970

The University of Tokyo
- 1970

Graduate School, Division of Science, The University of Tokyo
- 1963

Faculty of Science, The University of Tokyo
- 1963

Faculty of Science, The University of Tokyo

Committee Memberships

Awards

1987

斉藤賞

Misc.

SEQUESTRATION OF MUSCARINIC ACETYLCHOLINE-RECEPTOR M2 SUBTYPES - FACILITATION BY G-PROTEIN-COUPLED RECEPTOR KINASE (GRK2) AND ATTENUATION BY A DOMINANT-NEGATIVE MUTANT OF GRK2

H TSUGA, K KAMEYAMA, T HAGA, H KUROSE, T NAGAO

JOURNAL OF BIOLOGICAL CHEMISTRY, 269(51) 32522-32527, Dec, 1994
G protein-coupled receptor kinases.

J. Neurochem., 63,400-412, 1994
Solubilization of muscarinic receptor subtypes from baculovirus infected Sf9 insect cells.

Biochem Pharmacol, 48,1245-1251, 1994
Location of agonist-dependent-phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype).

Eur. J. Biochem., 220,29-36, 1994
Activation of a GTP-binding protein and a GTP-binding-protein-coupled receptor kinase(β-adenergic-receptor Kinase-1) by a muscarinic receptor m2 mutant lacking phosphorylation sites.

Eur. J. Biochem., 226,267-276, 1994
Synergistic activation of a G protein-coupled receptor kinase by G protein βγ subunits and mastoparan or related peptides.

J. Biol. Chem., 269,12594-12599, 1994
Solubilization and characterization of atrial muscarinic acetylcholine receptors in sucrose monolaurate.

Arch. Biochem. Biophys., 301,158-164, 1993
Phosphorylation of muscarinic receptors : Regulation by G proteins.

Life Sci., 52,421-428, 1993
Activation by G protein βγ subunits of β adrenergic and muscarinic receptor kinase.

J. Biol. Chem., 268,7753-7758, 1993
Effects of magnesium ion on the interaction of atrial muscarinic acetylcholine receptors and GTP-binding regulatory proteins.

Biochemistry, 31,10634-10642, 1992
Activation by G protein βγ subunits of agonist- or light-dependent phosphorylation of muscarinic acetylcholine receptors and rhodopsin

J. Biol. Chem., 267,2222-2227, 1992
Location in muscarinic acetylcholine receptors of sites for [3H] propylbenzilylcholine mustard binding and for phosphorylation with protein kinase C.

J. Neurochem., 54,1870-1811, 1990
Identification of two novel GTP-binding protein α-subunits that lack apparent ADP-ribosylation sites for pertussis toxin.

J. Biol. Chem., 266,12676-12681, 1989
Effect of the lipid environment on the differential affinity of purified cerebral and atrial muscarinic acetylcholine receptors for pirenzepine.

Mol. Pharmacol., 36,601-607, 1989
Molecular properties of muscarinic receptors.

Trends. Pharmacol. Sci. Suppl, 12-18, 1988
Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence.

FEBS Lett., 197,305-310, 1986
Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.

J. Biol. Chem., 261,6423-6428, 1986
Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

Nature, 323,411-416, 1986
Reconstitution of the muscarinic acetylcholine receptor : guanine mucleotide-sensitive high affinity binding of agonist to purified muscarinic receptors reconstituted with GTP-binding proteins (Gi and Go)

J. Biol. Chem., 261,10133-10140, 1986
Primary structure of the alpha-subunit of transducin and its relationship to ras proteins.

Nature, 315,242-245, 1985
Purification of the muscarinic acetylcholine receptor from porcine brain

J. Biol. Chem., 260,7927-7935, 1985
Affinity chromatography of the muscarinic acetylcholine receptor

J. Biol. Chem., 258,13575-13579, 1983
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells

Proc. Natl. Acal. Sci., 74,2016-2020, 1977
Hydrodynamic properties of the β-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells

J. Biol. Chem., 252,5776-5782, 1977
Microtubule formation from two components separated by gel filtration of a tubulin preparation

Biochim. Biophys. Acta., 392,335-345, 1975
Choline uptake systems of rat brain synaptosomes

Biochim. Biophys. Acta, 291,564-575, 1973
Synthesis and release of [₁₄C]acetylcholine in synaptosomes

J. Neurochem., 18,781-798, 1971

Books and Other Publications

G Protein-Coupled Receptors Ed. by T. Hga and G. Berstein

CRC. Press, 1999
Receptor Biochemistry. In : Encyclopedia of Molecular Biology and Molecular Medicine

Medicine, Volume 5, edited by Meyers, R. A. Weiheim, New York, Basel, Cambridge, Tokyo : VCH, 1997
G protein-coupled receptor kinase : Phosphorylation of muscarinic receptors and facilitation of receptor sequestration.

Advances in Pharmacology, Volume 36 : Intracellular Signal Transduction, edited by Hidaka, H. and Nairin, A. C. San Diego, New York, Boston, London, Sydney, Tokyo, Toronto : Academic Press, 1996
Phosphorylation and sequestration of muscarinic receptors. In : Molecular mechanisms of muscarinic acetylcholine receptor function

R. G. Landrs Company, Biomedical Publishers Austin, Texas, 1995
Solubilization, purification, and molecular characterization of receptors : principles and strategy.

In : Receptor biochemistry, A practical approach, edited by Hulme, E. C. Oxford : Oxford University Press, 1990

Professional Memberships

Research Projects

Gタンパク質共役受容体の新規リガンド検索
高親和性コリントランスポーターの構造と機能制御

基礎科学研究
神経伝達物質受容体の生化学

基礎科学研究
Screening of ligands for orphan GPCRs
Structure and Regulation of High-affinity choline Transporter

Industrial Property Rights

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