芳賀達也

ハガタツヤ (Tatsuya Haga)

基本情報

所属: 学習院大学理学部化学科生物化学専攻教授,生命分子科学研究所所長

学位: 理学博士(東京大学)
理学修士
理学博士

J-GLOBAL ID: 200901090206888960
researchmap会員ID: 1000011101

外部リンク: http://www.gakushuin.ac.jp/univ/sci/chem/thj.html

研究キーワード

研究分野

経歴

1988年 - 2001年

東京大学医学部教授
1988年 - 2001年

Professor, Faculty of Medicine, Tokyo Univ.
2001年

- 学習院大学理学部教授
2001年

- Professor, Faculty of Science, Gaku shuin Univ
1974年 - 1988年

浜松医科大学医学部助教授

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学歴

委員歴

受賞

1987年

斉藤賞

MISC

SEQUESTRATION OF MUSCARINIC ACETYLCHOLINE-RECEPTOR M2 SUBTYPES - FACILITATION BY G-PROTEIN-COUPLED RECEPTOR KINASE (GRK2) AND ATTENUATION BY A DOMINANT-NEGATIVE MUTANT OF GRK2

H TSUGA, K KAMEYAMA, T HAGA, H KUROSE, T NAGAO

JOURNAL OF BIOLOGICAL CHEMISTRY 269(51) 32522-32527 1994年12月
G protein-coupled receptor kinases.

J. Neurochem. 63,400-412 1994年
Solubilization of muscarinic receptor subtypes from baculovirus infected Sf9 insect cells.

Biochem Pharmacol 48,1245-1251 1994年
Location of agonist-dependent-phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype).

Eur. J. Biochem. 220,29-36 1994年
Activation of a GTP-binding protein and a GTP-binding-protein-coupled receptor kinase(β-adenergic-receptor Kinase-1) by a muscarinic receptor m2 mutant lacking phosphorylation sites.

Eur. J. Biochem. 226,267-276 1994年
Synergistic activation of a G protein-coupled receptor kinase by G protein βγ subunits and mastoparan or related peptides.

J. Biol. Chem. 269,12594-12599 1994年
Solubilization and characterization of atrial muscarinic acetylcholine receptors in sucrose monolaurate.

Arch. Biochem. Biophys. 301,158-164 1993年
Phosphorylation of muscarinic receptors : Regulation by G proteins.

Life Sci. 52,421-428 1993年
Activation by G protein βγ subunits of β adrenergic and muscarinic receptor kinase.

J. Biol. Chem. 268,7753-7758 1993年
Effects of magnesium ion on the interaction of atrial muscarinic acetylcholine receptors and GTP-binding regulatory proteins.

Biochemistry 31,10634-10642 1992年
Activation by G protein βγ subunits of agonist- or light-dependent phosphorylation of muscarinic acetylcholine receptors and rhodopsin

J. Biol. Chem. 267,2222-2227 1992年
Location in muscarinic acetylcholine receptors of sites for [3H] propylbenzilylcholine mustard binding and for phosphorylation with protein kinase C.

J. Neurochem. 54,1870-1811 1990年
Identification of two novel GTP-binding protein α-subunits that lack apparent ADP-ribosylation sites for pertussis toxin.

J. Biol. Chem. 266,12676-12681 1989年
Effect of the lipid environment on the differential affinity of purified cerebral and atrial muscarinic acetylcholine receptors for pirenzepine.

Mol. Pharmacol. 36,601-607 1989年
Molecular properties of muscarinic receptors.

Trends. Pharmacol. Sci. Suppl 12-18 1988年
Primary structure of the alpha-subunit of bovine adenylate cyclase-inhibiting G-protein deduced from the cDNA sequence.

FEBS Lett. 197,305-310 1986年
Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.

J. Biol. Chem. 261,6423-6428 1986年
Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

Nature 323,411-416 1986年
Reconstitution of the muscarinic acetylcholine receptor : guanine mucleotide-sensitive high affinity binding of agonist to purified muscarinic receptors reconstituted with GTP-binding proteins (Gi and Go)

J. Biol. Chem. 261,10133-10140 1986年
Primary structure of the alpha-subunit of transducin and its relationship to ras proteins.

Nature 315,242-245 1985年
Purification of the muscarinic acetylcholine receptor from porcine brain

J. Biol. Chem. 260,7927-7935 1985年
Affinity chromatography of the muscarinic acetylcholine receptor

J. Biol. Chem. 258,13575-13579 1983年
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells

Proc. Natl. Acal. Sci. 74,2016-2020 1977年
Hydrodynamic properties of the β-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells

J. Biol. Chem. 252,5776-5782 1977年
Microtubule formation from two components separated by gel filtration of a tubulin preparation

Biochim. Biophys. Acta. 392,335-345 1975年
Choline uptake systems of rat brain synaptosomes

Biochim. Biophys. Acta 291,564-575 1973年
Synthesis and release of [₁₄C]acetylcholine in synaptosomes

J. Neurochem. 18,781-798 1971年

書籍等出版物

G Protein-Coupled Receptors Ed. by T. Hga and G. Berstein

CRC. Press 1999年
Receptor Biochemistry. In : Encyclopedia of Molecular Biology and Molecular Medicine

Medicine, Volume 5, edited by Meyers, R. A. Weiheim, New York, Basel, Cambridge, Tokyo : VCH 1997年
G protein-coupled receptor kinase : Phosphorylation of muscarinic receptors and facilitation of receptor sequestration.

Advances in Pharmacology, Volume 36 : Intracellular Signal Transduction, edited by Hidaka, H. and Nairin, A. C. San Diego, New York, Boston, London, Sydney, Tokyo, Toronto : Academic Press 1996年
Phosphorylation and sequestration of muscarinic receptors. In : Molecular mechanisms of muscarinic acetylcholine receptor function

R. G. Landrs Company, Biomedical Publishers Austin, Texas 1995年
Solubilization, purification, and molecular characterization of receptors : principles and strategy.

In : Receptor biochemistry, A practical approach, edited by Hulme, E. C. Oxford : Oxford University Press 1990年

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所属学協会

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共同研究・競争的資金等の研究課題

Gタンパク質共役受容体の新規リガンド検索
高親和性コリントランスポーターの構造と機能制御

基礎科学研究
神経伝達物質受容体の生化学

基礎科学研究
Screening of ligands for orphan GPCRs
Structure and Regulation of High-affinity choline Transporter

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産業財産権

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芳賀 達也

基本情報

研究キーワード

研究分野

経歴

学歴

委員歴

受賞

MISC

書籍等出版物

所属学協会

共同研究・競争的資金等の研究課題

産業財産権

芳賀達也