芳賀達也

ハガタツヤ (Tatsuya Haga)

基本情報

所属: 学習院大学理学部化学科生物化学専攻教授,生命分子科学研究所所長

学位: 理学博士(東京大学)
理学修士
理学博士

J-GLOBAL ID: 200901090206888960
researchmap会員ID: 1000011101

外部リンク: http://www.gakushuin.ac.jp/univ/sci/chem/thj.html

研究キーワード

研究分野

経歴

1988年 - 2001年

東京大学医学部教授
1988年 - 2001年

Professor, Faculty of Medicine, Tokyo Univ.
2001年

- 学習院大学理学部教授
2001年

- Professor, Faculty of Science, Gaku shuin Univ
1974年 - 1988年

浜松医科大学医学部助教授

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学歴

委員歴

受賞

1987年

斉藤賞

MISC

High-affinity choline transporter

Takashi Okuda, Tatsuya Haga

Neurochemical Research 28(3-4) 483-488 2003年4月1日
"Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in β-tubulin"

Eur. j. Biochem. 270(6) 1154-1163 2003年3月
Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in beta-tubulin

N Yoshida, K Haga, T Haga

EUROPEAN JOURNAL OF BIOCHEMISTRY 270(6) 1154-1163 2003年3月
Detection of the high-affinity choline transporter in the MOLT-3 human leukemic T-cell line

Life Sciences 72, 2131-2134 2003年
"Detection of the high-affinity choline transporter in the MOLT-3 human leukemic T-cell line"

Life Sciences 72. 2131-2134 2003年
" High-affinity choline transporter" neurochemical research

Neurochemical Research 28, 483-488 2003年
Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate

T Okuda, M Okamura, C Kaitsuka, T Haga, D Gurwitz

JOURNAL OF BIOLOGICAL CHEMISTRY 277(47) 45315-45322 2002年11月
Opsin-G₁₁-mediated signaling pathway for photic entrainment of the chicken pineal circadian clock

Journal of Neuroscience 22, 7321-7325 2002年
Effects of toluene exposure on signal transduction : toluene reduced the signaling via stimulation of human muscarinic acetylcholine receptor m2 Subtypes i n CHo cells

Jpn. J. Pharmacol. 89, 282-289 2002年
Identification of G protein-coupled receptor genes from the human genome sequence

FEBS Letters 520, 97-101 2002年
Distribution of the high-affinity choline transporter in the human and macazue monkey spinal cohd

Neuroscience Letters 317, 25-28 2002年
Regulation of G protein-coupled receptor kinase 2

Methods in Enzymology 343, 559-557 2002年
Opsin-G₁₁-mediated signaling pathway for photic entrainment of the chicken pineal circadian clock

J. Neurosci 22, 7321-7325 2002年
Effects of toluene exposure on signal transduction : Toluene reduced the signaling via stimulation of human muscarinic acetylcholine receptor m2 subtypes i n CHO cells

Jpn. J. Pharmacol. 89, 282-289 2002年
Identification of G protein-coupled receptor genes from the human genome sequence

FEBS Letters 520, 97-101 2002年
Distribution of the high-affinity choline transporter in the human and macazue monkey spinal cond

Neuroscience Letters 317, 25-28 2002年
Regulation of G protein-coupled Receptor Kinase 2

Methods in Enzymology 343, 559-557 2002年
Clathrin Box in G Protein-coupled Receptor Kinase 2

Takako Shiina, Ken Arai, Shihori Tanabe, Norihiro Yoshida, Tatsuya Haga, Taku Nagao, Hitoshi Kurose

Journal of Biological Chemistry 276(35) 33019-33026 2001年8月31日
Molecular bisis of order discriumination: reconstitution of olfactory receptors that reeognize overlapping sets of odorants

J. Newrosci 21, 6018-6025 2001年
Control of the cardiac muscarinic K+ channel by beta-Arrnestin 2

J. Biol. Chem. 276, 11691-11697 2001年
Distribution of the high-affinity choline transporter in the central nervous system of the rat

Neuroscience 105, 87-98 2001年
Receptor-Galpha fusion proteins as a tool for ligand screening

Life Science 68, 2319-2327 2001年
Molecular bases of odor discrination: reconstitution of olfactory receptors that recognize overiapping sets of odorants

J. Neurosci. 21, 6018-6025 2001年
Control of the cardiac muscarinic K+ channel by β-arrestin 2

J. Biol. Chem. 276, 11691-11697 2001年
Distribution of the high-affinity choline transporter in the central nervous system of the rat

Neeroscience 105, 87-98 2001年
Receptor-Gα Fusion Proteins as a Tool for Ligand Screening

Life Science 68, 2319-2327 2001年
Soluble P-type ATPase from an archaeon, Methanococcus jannaschii

H Ogawa, T Haga, C Toyoshima

FEBS LETTERS 471(1) 99-102 2000年4月
RGS domain in the amino terminus of G protein coupled receptor kinase 2 inhibits Gq-mediated signaling.

Int. J. Mol. Med. 5(4) 335-340 2000年
Molecular modeling of G-protein coupled receptor kinase 2 : Docking and biochemical evaluation of inhibitor.

AAPS Pharmsci. 2(1) article 2 2000年
Expression of functional M₂ muscarinic acetylcholine receptor in Escherichia colil.

J. Biochem. 127, 151-161 2000年
Identification and characterization of the high-affinity choline transporter.

Nature Neuroscience 3, 120-125 2000年
Alterations of muscarinic acetylcholine receptor subtypes in diffuse Lewy body disease : Relation to Alzheimer's disease.

J. Neurol. Neurosrurg. Psychiatry 67, 209-213 1999年
Functional identification and reconstitution of an odorant receptor in single olfactory neurons.

Proc. Natl. Acad. Sci. USA 96(7) 4040-4045 1999年
Control elements of muscarinic receptor gene expression.

Life Sci. 64, 479-486 1999年
Dynamin and rab5 regulate GRK2-dependent internalization of dopamine D2 receptors.

Eur. J. Biochemi 260, 596-602 1999年
Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5.

Eur. Biochem. 260,112-119 1999年
Role of receptor kinase in short-term desensitization of cardiac muscarinic K+ channels expressed in Chinese hamster ovary cells

Z Shui, IA Khan, H Tsuga, T Haga, MR Boyett

JOURNAL OF PHYSIOLOGY-LONDON 507(2) 325-334 1998年3月
GTP-binding-protein-coupled receptor kinase 2(GRK2)binds and phosphorylates tubulin

Eur. J. Biochem 255(2) 363-368 1998年
Sequestration of human muscarinic acetylcholine receptor hm1-hm5 subtypes : Effect of G Protin-coupled receptor kinases GRK2, GRK4, GRK5 and GRK6

J. Pharm. Exp. Ther. 284(3) 1218-1826 1998年
Internalization and down-regulation of human muscarinic acetylcholine receptor m2 subtypes

J. Biol. Chem. 273(9) 5323-5330 1998年
Expression of the rat m4 muscarinic acetylcholine receptor gene is regulated by the neuron-restrictive silencer element/repressor element 1.

J. Biol. Chem. 272,5854-5860 1997年
Palmitoylation of muscarinic acetylcholine receptor m2 subtypes : Reduction in their ability to activate G proteins by mutation of a putative palmitoylation site, cysteine 457, in the carboxyl-terminal tail.

Arch. Biochem. Biophys. 340,376-382 1997年
Ca2-dependent inhibition of G protein-coupled receptor kinase 2 by calmodulin.

Biochemistry 36,1315-1321 1997年
Purification and functional reconstitution with GTP-binding regulatory proteins of hexahistidine-tagged muscarinic acetylcholine receptors(m2 subtype).

J. Biochem. 120,1232-1238 1996年
Sequestration of the short and long isoforms of dopamine D₂ receptors expressed in chinese hamster ovary cells

Mol. Pharm. 49,560-566 1996年
Promotor region of the rat m4 muscarinic acetylcholine receptor gene contains a cell type-specific silencer element

J. Biol. Chem. 271(9) 5177-5182 1996年
Phosphorylation of human m1 muscarinic acetyeleholine receptors by G protein-coupled receptor kinase 2 and protein kinase c

J. Biol. Chem. 271(5) 2776-2782 1996年
CHARACTERIZATION OF G(Q) FAMILY G-PROTEINS G(L1)ALPHA(G(14)ALPHA), G(L2)ALPHA(G(11)ALPHA), AND G(Q)ALPHA EXPRESSED IN THE BACULOVIRUS-INSECT CELL SYSTEM

F NAKAMURA, M KATO, K KAMEYAMA, T NUKADA, T HAGA, N KATO, T TAKENAWA, U KIKKAWA

JOURNAL OF BIOLOGICAL CHEMISTRY 270(11) 6246-6253 1995年3月
Allosteric binding of 9-methoxy-alpha-lapachone and alcuronium to the muscarinic acetylcholine receptor m2 subtype

Biomed. Res. 16,327-335 1995年
Ligand binding properties of muscarinic acetyicholine receptor subtypes (m1-m5) expressed in baculovirus-infected insect cells

J. Pharmacol. Exp. Ther. 274,378-384 1995年

書籍等出版物

G Protein-Coupled Receptors Ed. by T. Hga and G. Berstein

CRC. Press 1999年
Receptor Biochemistry. In : Encyclopedia of Molecular Biology and Molecular Medicine

Medicine, Volume 5, edited by Meyers, R. A. Weiheim, New York, Basel, Cambridge, Tokyo : VCH 1997年
G protein-coupled receptor kinase : Phosphorylation of muscarinic receptors and facilitation of receptor sequestration.

Advances in Pharmacology, Volume 36 : Intracellular Signal Transduction, edited by Hidaka, H. and Nairin, A. C. San Diego, New York, Boston, London, Sydney, Tokyo, Toronto : Academic Press 1996年
Phosphorylation and sequestration of muscarinic receptors. In : Molecular mechanisms of muscarinic acetylcholine receptor function

R. G. Landrs Company, Biomedical Publishers Austin, Texas 1995年
Solubilization, purification, and molecular characterization of receptors : principles and strategy.

In : Receptor biochemistry, A practical approach, edited by Hulme, E. C. Oxford : Oxford University Press 1990年

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所属学協会

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共同研究・競争的資金等の研究課題

Gタンパク質共役受容体の新規リガンド検索
高親和性コリントランスポーターの構造と機能制御

基礎科学研究
神経伝達物質受容体の生化学

基礎科学研究
Screening of ligands for orphan GPCRs
Structure and Regulation of High-affinity choline Transporter

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産業財産権

一覧へ戻る

芳賀 達也

基本情報

研究キーワード

研究分野

経歴

学歴

委員歴

受賞

MISC

書籍等出版物

所属学協会

共同研究・競争的資金等の研究課題

産業財産権

芳賀達也