Tatsuya Haga

(芳賀達也)

Profile Information

Affiliation: Professor, Faculty of Science, Department of Chemistry, Biochemistry, Gakushuin University

Degree: Ph.D.(The University of Tokyo)
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J-GLOBAL ID: 200901090206888960
researchmap Member ID: 1000011101

External link: http://www.gakushuin.ac.jp/univ/sci/bio/main.html

Research Interests

Research Areas

Research History

1988 - 2001

Faculty of Medicine, The University of Tokyo
1988 - 2001

Professor, Faculty of Medicine, Tokyo Univ.
2001

- 学習院大学理学部教授
2001

- Professor, Faculty of Science, Gaku shuin Univ
1974 - 1988

Faculty of Medicine, Hamamatsu University School of Medicine

Education

- 1970

The University of Tokyo
- 1970

Graduate School, Division of Science, The University of Tokyo
- 1963

Faculty of Science, The University of Tokyo
- 1963

Faculty of Science, The University of Tokyo

Committee Memberships

Awards

1987

斉藤賞

Misc.

High-affinity choline transporter

Takashi Okuda, Tatsuya Haga

Neurochemical Research, 28(3-4) 483-488, Apr 1, 2003
Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in beta-tubulin

N Yoshida, K Haga, T Haga

EUROPEAN JOURNAL OF BIOCHEMISTRY, 270(6) 1154-1163, Mar, 2003
Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in beta-tubulin

N Yoshida, K Haga, T Haga

EUROPEAN JOURNAL OF BIOCHEMISTRY, 270(6) 1154-1163, Mar, 2003
Detection of the high-affinity choline transporter in the MOLT-3 human leukemic T-cell line

Life Sciences, 72, 2131-2134, 2003
"Detection of the high-affinity choline transporter in the MOLT-3 human leukemic T-cell line"

Life Sciences, 72. 2131-2134, 2003
" High-affinity choline transporter" neurochemical research

Neurochemical Research, 28, 483-488, 2003
Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate

T Okuda, M Okamura, C Kaitsuka, T Haga, D Gurwitz

JOURNAL OF BIOLOGICAL CHEMISTRY, 277(47) 45315-45322, Nov, 2002
Opsin-G₁₁-mediated signaling pathway for photic entrainment of the chicken pineal circadian clock

Journal of Neuroscience, 22, 7321-7325, 2002
Effects of toluene exposure on signal transduction : toluene reduced the signaling via stimulation of human muscarinic acetylcholine receptor m2 Subtypes i n CHo cells

Jpn. J. Pharmacol., 89, 282-289, 2002
Identification of G protein-coupled receptor genes from the human genome sequence

FEBS Letters, 520, 97-101, 2002
Distribution of the high-affinity choline transporter in the human and macazue monkey spinal cohd

Neuroscience Letters, 317, 25-28, 2002
Regulation of G protein-coupled receptor kinase 2

Methods in Enzymology, 343, 559-557, 2002
Opsin-G₁₁-mediated signaling pathway for photic entrainment of the chicken pineal circadian clock

J. Neurosci, 22, 7321-7325, 2002
Effects of toluene exposure on signal transduction : Toluene reduced the signaling via stimulation of human muscarinic acetylcholine receptor m2 subtypes i n CHO cells

Jpn. J. Pharmacol., 89, 282-289, 2002
Identification of G protein-coupled receptor genes from the human genome sequence

FEBS Letters, 520, 97-101, 2002
Distribution of the high-affinity choline transporter in the human and macazue monkey spinal cond

Neuroscience Letters, 317, 25-28, 2002
Regulation of G protein-coupled Receptor Kinase 2

Methods in Enzymology, 343, 559-557, 2002
Clathrin Box in G Protein-coupled Receptor Kinase 2

Takako Shiina, Ken Arai, Shihori Tanabe, Norihiro Yoshida, Tatsuya Haga, Taku Nagao, Hitoshi Kurose

Journal of Biological Chemistry, 276(35) 33019-33026, Aug 31, 2001
Molecular bisis of order discriumination: reconstitution of olfactory receptors that reeognize overlapping sets of odorants

J. Newrosci, 21, 6018-6025, 2001
Control of the cardiac muscarinic K+ channel by beta-Arrnestin 2

J. Biol. Chem., 276, 11691-11697, 2001
Distribution of the high-affinity choline transporter in the central nervous system of the rat

Neuroscience, 105, 87-98, 2001
Receptor-Galpha fusion proteins as a tool for ligand screening

Life Science, 68, 2319-2327, 2001
Molecular bases of odor discrination: reconstitution of olfactory receptors that recognize overiapping sets of odorants

J. Neurosci., 21, 6018-6025, 2001
Control of the cardiac muscarinic K+ channel by β-arrestin 2

J. Biol. Chem., 276, 11691-11697, 2001
Distribution of the high-affinity choline transporter in the central nervous system of the rat

Neeroscience, 105, 87-98, 2001
Receptor-Gα Fusion Proteins as a Tool for Ligand Screening

Life Science, 68, 2319-2327, 2001
Soluble P-type ATPase from an archaeon, Methanococcus jannaschii

H Ogawa, T Haga, C Toyoshima

FEBS LETTERS, 471(1) 99-102, Apr, 2000
RGS domain in the amino terminus of G protein coupled receptor kinase 2 inhibits Gq-mediated signaling.

Int. J. Mol. Med., 5(4) 335-340, 2000
Molecular modeling of G-protein coupled receptor kinase 2 : Docking and biochemical evaluation of inhibitor.

AAPS Pharmsci., 2(1) article 2, 2000
Expression of functional M₂ muscarinic acetylcholine receptor in Escherichia colil.

J. Biochem., 127, 151-161, 2000
Identification and characterization of the high-affinity choline transporter.

Nature Neuroscience, 3, 120-125, 2000
Alterations of muscarinic acetylcholine receptor subtypes in diffuse Lewy body disease : Relation to Alzheimer's disease.

J. Neurol. Neurosrurg. Psychiatry, 67, 209-213, 1999
Functional identification and reconstitution of an odorant receptor in single olfactory neurons.

Proc. Natl. Acad. Sci. USA, 96(7) 4040-4045, 1999
Control elements of muscarinic receptor gene expression.

Life Sci., 64, 479-486, 1999
Dynamin and rab5 regulate GRK2-dependent internalization of dopamine D2 receptors.

Eur. J. Biochemi, 260, 596-602, 1999
Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5.

Eur. Biochem., 260,112-119, 1999
Role of receptor kinase in short-term desensitization of cardiac muscarinic K+ channels expressed in Chinese hamster ovary cells

Z Shui, IA Khan, H Tsuga, T Haga, MR Boyett

JOURNAL OF PHYSIOLOGY-LONDON, 507(2) 325-334, Mar, 1998
GTP-binding-protein-coupled receptor kinase 2(GRK2)binds and phosphorylates tubulin

Eur. J. Biochem, 255(2) 363-368, 1998
Sequestration of human muscarinic acetylcholine receptor hm1-hm5 subtypes : Effect of G Protin-coupled receptor kinases GRK2, GRK4, GRK5 and GRK6

J. Pharm. Exp. Ther., 284(3) 1218-1826, 1998
Internalization and down-regulation of human muscarinic acetylcholine receptor m2 subtypes

J. Biol. Chem., 273(9) 5323-5330, 1998
Expression of the rat m4 muscarinic acetylcholine receptor gene is regulated by the neuron-restrictive silencer element/repressor element 1.

J. Biol. Chem., 272,5854-5860, 1997
Palmitoylation of muscarinic acetylcholine receptor m2 subtypes : Reduction in their ability to activate G proteins by mutation of a putative palmitoylation site, cysteine 457, in the carboxyl-terminal tail.

Arch. Biochem. Biophys., 340,376-382, 1997
Ca2-dependent inhibition of G protein-coupled receptor kinase 2 by calmodulin.

Biochemistry, 36,1315-1321, 1997
Purification and functional reconstitution with GTP-binding regulatory proteins of hexahistidine-tagged muscarinic acetylcholine receptors(m2 subtype).

J. Biochem., 120,1232-1238, 1996
Sequestration of the short and long isoforms of dopamine D₂ receptors expressed in chinese hamster ovary cells

Mol. Pharm., 49,560-566, 1996
Promotor region of the rat m4 muscarinic acetylcholine receptor gene contains a cell type-specific silencer element

J. Biol. Chem., 271(9) 5177-5182, 1996
Phosphorylation of human m1 muscarinic acetyeleholine receptors by G protein-coupled receptor kinase 2 and protein kinase c

J. Biol. Chem., 271(5) 2776-2782, 1996
CHARACTERIZATION OF G(Q) FAMILY G-PROTEINS G(L1)ALPHA(G(14)ALPHA), G(L2)ALPHA(G(11)ALPHA), AND G(Q)ALPHA EXPRESSED IN THE BACULOVIRUS-INSECT CELL SYSTEM

F NAKAMURA, M KATO, K KAMEYAMA, T NUKADA, T HAGA, N KATO, T TAKENAWA, U KIKKAWA

JOURNAL OF BIOLOGICAL CHEMISTRY, 270(11) 6246-6253, Mar, 1995
Allosteric binding of 9-methoxy-alpha-lapachone and alcuronium to the muscarinic acetylcholine receptor m2 subtype

Biomed. Res., 16,327-335, 1995
Ligand binding properties of muscarinic acetyicholine receptor subtypes (m1-m5) expressed in baculovirus-infected insect cells

J. Pharmacol. Exp. Ther., 274,378-384, 1995

Books and Other Publications

G Protein-Coupled Receptors Ed. by T. Hga and G. Berstein

CRC. Press, 1999
Receptor Biochemistry. In : Encyclopedia of Molecular Biology and Molecular Medicine

Medicine, Volume 5, edited by Meyers, R. A. Weiheim, New York, Basel, Cambridge, Tokyo : VCH, 1997
G protein-coupled receptor kinase : Phosphorylation of muscarinic receptors and facilitation of receptor sequestration.

Advances in Pharmacology, Volume 36 : Intracellular Signal Transduction, edited by Hidaka, H. and Nairin, A. C. San Diego, New York, Boston, London, Sydney, Tokyo, Toronto : Academic Press, 1996
Phosphorylation and sequestration of muscarinic receptors. In : Molecular mechanisms of muscarinic acetylcholine receptor function

R. G. Landrs Company, Biomedical Publishers Austin, Texas, 1995
Solubilization, purification, and molecular characterization of receptors : principles and strategy.

In : Receptor biochemistry, A practical approach, edited by Hulme, E. C. Oxford : Oxford University Press, 1990

Professional Memberships

Research Projects

Gタンパク質共役受容体の新規リガンド検索
高親和性コリントランスポーターの構造と機能制御

基礎科学研究
神経伝達物質受容体の生化学

基礎科学研究
Screening of ligands for orphan GPCRs
Structure and Regulation of High-affinity choline Transporter

Industrial Property Rights

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