Takashi Hishida

(菱田卓)

Profile Information

Affiliation: Faculty of ScienceDepartment of Life Science, Gakushuin University

J-GLOBAL ID: 200901001733863530
researchmap Member ID: 1000317623

External link: https://www.univ.gakushuin.ac.jp/sci/bio/

Research Interests

Research Areas

Research History

Apr, 2011 - Present

Faculty of Science, Department of Life Science, Gakushuin University
Apr, 2007 - Mar, 2011

Research Institute for Microbial Diseases, Osaka University
Jul, 2005 - Mar, 2007

Research Institute for Microbial Diseases, Osaka University
Apr, 2001 - Jun, 2005

Research Institute for Microbial Diseases, Osaka University
Apr, 2000 - Mar, 2001

日本学術振興会特別研究員（PD）

Papers

Topological DNA-binding of structural maintenance of chromosomes-like RecN promotes DNA double-strand break repair in Escherichia coli.

Keyamura K, Hishida T

Communications biology, 2 413, 2019 Peer-reviewed
Cyclin-dependent kinase modulates budding yeast Rad5 stability during cell cycle.

Hayashi M, Keyamura K, Hishida T

PloS one, 13(9) e0204680-e0204680, 2018 Peer-reviewed
Srs2 and Mus81–Mms4 Prevent Accumulation of Toxic Inter-Homolog Recombination Intermediates

Kenji Keyamura, Kota Arai, Takashi Hishida

PLoS Genetics, 12(7) e1006136, Jul 1, 2016 Peer-reviewed
RecA Protein Recruits Structural Maintenance of Chromosomes (SMC)-like RecN Protein to DNA Double-strand Breaks

Kenji Keyamura, Chikako Sakaguchi, Yoshino Kubota, Hironori Niki, Takashi Hishida

JOURNAL OF BIOLOGICAL CHEMISTRY, 288(41) 29229-29237, Oct, 2013 Peer-reviewed
En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2-E3 pairs

Yuji Masuda, Miki Suzuki, Hidehiko Kawai, Asami Hishiki, Hiroshi Hashimoto, Chikahide Masutani, Takashi Hishida, Fumio Suzuki, Kenji Kamiya

NUCLEIC ACIDS RESEARCH, 40(20) 10394-10407, Nov, 2012 Peer-reviewed
Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells

Nami Haruta, Yoshino Kubota, Takashi Hishida

NUCLEIC ACIDS RESEARCH, 40(17) 8406-8415, Sep, 2012 Peer-reviewed
Srs2 Plays a Critical Role in Reversible G(2) Arrest upon Chronic and Low Doses of UV Irradiation via Two Distinct Homologous Recombination-Dependent Mechanisms in Postreplication Repair-Deficient Cells

Takashi Hishida, Yoshihiro Hirade, Nami Haruta, Yoshino Kubota, Hiroshi Iwasaki

MOLECULAR AND CELLULAR BIOLOGY, 30(20) 4840-4850, Oct, 2010 Peer-reviewed
PCNA Mono-Ubiquitination and Activation of Translesion DNA Polymerases by DNA Polymerase alpha

Motoshi Suzuki, Atsuko Niimi, Siripan Limsirichaikul, Shuta Tomida, Qin Miao Huang, Shunji Izuta, Jiro Usukura, Yasutomo Itoh, Takashi Hishida, Tomohiro Akashi, Yoshiyuki Nakagawa, Akihiko Kikuchi, Youri Pavlov, Takashi Murate, Takashi Takahashi

JOURNAL OF BIOCHEMISTRY, 146(1) 13-21, Jul, 2009 Peer-reviewed
[DNA damage tolerance through replication bypass of stalled replication forks].

Hishida T

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54(4 Suppl) 388-393, Mar, 2009
RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

Takashi Hishida, Yoshino Kubota, Antony M. Carr, Hiroshi Iwasaki

NATURE, 457(7229) 612-U124, Jan, 2009 Peer-reviewed
A SUMO-like domain protein, Esc2, is required for genome integrity and sister chromatid cohesion in Saccharomyces cerevisiae

Tomoko Ohya, Hirokazu Arai, Yoshino Kubota, Hideo Shinagawa, Takashi Hishida

GENETICS, 180(1) 41-50, Sep, 2008 Peer-reviewed
Essential and distinct roles of the F-box and helicase domains of Fbh1 in DNA damage repair

Chikako Sakaguchi, Takashi Morishita, Hideo Shinagawa, Takashi Hishida

BMC MOLECULAR BIOLOGY, 9 27, Mar, 2008 Peer-reviewed
Molecular mechanisms of RAD 6 DNA damage tolerance pathway in Saccharomyces cerevisiae

Takashi Hishida

Seikagaku, 80(2) 124-128, 2008
Degradation of Escherichia coli RecN aggregates by ClpXP protease and its implications for DNA damage tolerance

Kohji Nagashima, Yoshino Kubota, Tatsuya Shibata, Chikako Sakaguchi, Hideo Shinagawa, Takashi Hishida

JOURNAL OF BIOLOGICAL CHEMISTRY, 281(41) 30941-30946, Oct, 2006 Peer-reviewed
Functional and physical interaction of yeast Mgs1 with PCNA: Impact on RAD6-dependent DNA damage tolerance

Takashi Hishida, Tomoko Ohya, Yoshino Kubota, Yusuke Kamada, Hideo Shinagawa

MOLECULAR AND CELLULAR BIOLOGY, 26(14) 5509-5517, Jul, 2006 Peer-reviewed
Direct observation of DNA rotation during branch migration of Holliday junction DNA by Escherichia coli RuvA-RuvB protein complex

Han Y.W, Tani, T, Hayashi, M, Hishida T, Iwasaki H, Shinagawa H, Harada Y

Proc. Natl. Acad. Sci. U S A, 103 11544-11548, 2006 Peer-reviewed
Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest

Miyabe, I, T Morishita, T Hishida, S Yonei, H Shinagawa

MOLECULAR AND CELLULAR BIOLOGY, 26(1) 343-353, Jan, 2006 Peer-reviewed
Structure-function analysis of the three domains of RuvB DNA motor protein

T Ohnishi, T Hishida, Y Harada, H Iwasaki, H Shinagawa

JOURNAL OF BIOLOGICAL CHEMISTRY, 280(34) 30504-30510, Aug, 2005 Peer-reviewed
Functional overlap between RecA and MgsA (RarA) in the rescue of stalled replication forks in Escherichia coli

T Shibata, T Hishida, Y Kubota, YW Han, H Iwasaki, H Shinagawa

GENES TO CELLS, 10(3) 181-191, Mar, 2005 Peer-reviewed
Role of the Escherichia coli RecQ DNA helicase in SOS signaling and genome stabilization at stalled replication forks

T Hishida, YW Han, T Shibata, Y Kubota, Y Ishino, H Iwasaki, H Shinagawa

GENES & DEVELOPMENT, 18(15) 1886-1897, Aug, 2004 Peer-reviewed
Direct evidence that a conserved arginine in RuvB AAA(+) ATPase acts as an allosteric effector for the ATPase activity of the adjacent subunit in a hexamer

T Hishida, YW Han, S Fujimoto, H Iwasaki, H Shinagawa

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(26) 9573-9577, Jun, 2004 Peer-reviewed
Uncoupling of the ATPase activity from the branch migration activity of RuvAB protein complexes containing both wild-type and ATPase-defective RuvB proteins.

Hishida T, Iwasaki H, Han Y-W, Ohnishi T, Shinagawa H

Genes to cells, 9 721-730, 2003 Peer-reviewed
Saccharomyces cerevisiae MGS1 is essential in strains deficient in the RAD6-dependent DNA damage tolerance pathway

T Hishida, T Ohno, H Iwasaki, H Shinagawa

EMBO JOURNAL, 21(8) 2019-2029, Apr, 2002 Peer-reviewed
A yeast gene, MGS1, encoding a DNA-dependent AAA⁺ ATPase is required to maintain genome stability

Hishida T, Iwasaki H, Ohno T, Morishita T, Shinagawa H

Proc Natl Acad Sci U S A., 98 8283-8289, 2001 Peer-reviewed
Role of Walker motif A of Ruv B protein in promoting branch migration of Holliday junctions, Walker motif A mutations affect ATP binding, ATP hydrolyzing and DNA binding activities of Ruv B

Hishida T, Iwasaki H, Yagi T, Shinagawa H

The journal of biological chemistry, 274(36) 5335-5342, 1999 Peer-reviewed
Mutational analysis on structure-function relationship of a Holliday junction specific endonuclease RuvC

Kenji Ichiyanagi, Hiroshi Iwasaki, Takashi Hishida, Hideo Shinagawa

Genes to Cells, 3(9) 575-586, 1998 Peer-reviewed
Molecular analysis of the Pseudomonas aeruginosa genes, ruvA, ruvB and ruvC, involved in processing of homologous recombination intermediates

T Hishida, H Iwasaki, K Ishioka, H Shinagawa

GENE, 182(1-2) 63-70, Dec, 1996 Peer-reviewed

Professional Memberships

Research Projects

_倍数体化と非対称分裂による環境ストレス耐性機能の解明

科学研究費補助金（基盤C）_, 文部科学省, 2017 - 2019

菱田卓
_環境適応型ＤＮＡ損傷ストレス耐性メカニズムの解明

科学研究費補助金（基盤A）_, 文部科学省, 2011 - 2015

菱田卓
_非コードＤＮＡ領域が果たすＤＮＡ損傷ストレス耐性機能

新学術領域研究(研究領域提案型), 文部科学省, 2011 - 2015

菱田卓
慢性的なDNA損傷ストレスへの暴露がゲノム安定性に及ぼす影響に関する研究

三菱財団, 2010 - 2011

菱田卓
慢性低紫外線環境ストレスによるゲノム損傷応答と耐性機構に関する研究

科学研究費補助金（基盤B）_, 文部科学省, 2008 - 2010

菱田卓

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