Kakegawa Wataru

(掛川渉)

Profile Information

Affiliation: Professor, Faculty of Science Department of Life Science, Gakushuin University
Keio University

Degree: 博士（医学）(Gunma University)

Researcher number: 70383718
J-GLOBAL ID: 200901083420920416
researchmap Member ID: 1000289653

Research Interests

Research Areas

Life sciences / Neuroscience - general /

Research History

Apr, 2025 - Present

Keio University
Apr, 2025 - Present

Professor, Faculty of Science Department of Life Science, Gakushuin University
Jul, 2016 - Mar, 2025

准教授, 医学部生理学Ｉ教室, 慶應義塾大学
Oct, 2011 - Jun, 2016

専任講師, 医学部生理学I教室, 慶應義塾大学
Apr, 2007 - Sep, 2011

助教, 医学部生理学I教室, 慶應義塾大学

Education

Apr, 1999 - Mar, 2003

生理学, 医学系研究科, Gunma University
Apr, 1997 - Mar, 1999

Gunma University
Apr, 1993 - Mar, 1997

Gunma University

Committee Memberships

Apr, 2023 - Present

評議員, 日本神経科学学会
Apr, 2023 - Present

ホームページ委員会委員長, 日本神経科学学会
Apr, 2018 - Present

評議員, 日本生理学会
Jan, 2020 - Mar, 2023

ホームページ委員会委員長, 日本神経科学学会
Jan, 2017 - Dec, 2019

ホームページ編集委員会委員, 日本神経科学学会

Awards

Nov, 2024

Nomura Tatsuji Award, In Vivo Synaptology for Elucidating the Molecular Basis of Learning and Memory
Sep, 2014

日本D-アミノ酸学会奨励賞, 日本D-アミノ酸学会

KAKEGAWA WATARU
Mar, 2013

入澤宏・彩記念若手奨励賞, 日本生理学会

KAKEGAWA WATARU
Apr, 2012

The Young Scientists’ Prize of the Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Study of the ionotropic glutamate receptors regulating learning and memory., 文部科学省

KAKEGAWA WATARU
Nov, 2011

慶應義塾大学医学部三四会奨励賞, D-セリン－グルタミン酸受容体シグナリングによるシナプス可塑性および記憶学習制御, 慶應義塾大学医学部三四会

KAKEGAWA WATARU

Papers

Ho15J - A new hotfoot allele in a hot spot in the gene encoding the delta 2 glutamate receptor

Junko Motohashi, Wataru Kakegawa, Michisuke Yuzaki

BRAIN RESEARCH, 1140(1) 153-160, Apr, 2007
The extreme C-terminus of GluR delta 2 is essential for induction of long-term depression in cerebellar slices

Kazuhisa Kohda, Wataru Kakegawa, Shinji Matsuda, Ryoichi Nakagami, Naomasa Kakiya, Michisuke Yuzaki

EUROPEAN JOURNAL OF NEUROSCIENCE, 25(5) 1357-1362, Mar, 2007
Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release

Tetsushi Sadakata, Wataru Kakegawa, Akira Mizoguchi, Miwa Washida, Ritsuko Katoh-Semba, Fumihiro Shutoh, Takehito Okamoto, Hisako Nakashima, Kazushi Kimura, Mika Tanaka, Yukiko Sekine, Shigeyoshi Itohara, Michisuke Yuzaki, Soichi Nagao, Teiichi Furuichi

JOURNAL OF NEUROSCIENCE, 27(10) 2472-2482, Mar, 2007
Ca2+ permeability of the channel pore is not essential for the delta 2 glutamate receptor to regulate synaptic plasticity and motor coordination

Wataru Kakegawa, Taisuke Miyazaki, Hirokazu Hirai, Junko Motohashi, Masayoshi Mishina, Masahiko Watanabe, Michisuke Yuzaki

JOURNAL OF PHYSIOLOGY-LONDON, 579(3) 729-735, Mar, 2007
ERK1/2 but not p38 MAP kinase is essential for the long-term depression in mouse cerebellar slices

Aya Ito-Ishida, Wataru Kakegawa, Michisuke Yuzaki

EUROPEAN JOURNAL OF NEUROSCIENCE, 24(6) 1617-1622, Sep, 2006
Excitotoxicity and autophagy: In vitro model of Lurcher mouse

Nishiyama Jun, Matsuda Keiko, Kakegawa Wataru, Yamada Nobuaki, Mizushima Noboru, Yuzaki Michisuke

NEUROSCIENCE RESEARCH, 55 S120, 2006 Peer-reviewed
A mechanism underlying AMPA receptor trafficking during cerebellar long-term potentiation

W Kakegawa, M Yuzaki

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(49) 17846-17851, Dec, 2005
Induction of long-term depression and phosphorylation of the delta 2 glutamate receptor by protein kinase C in cerebellar slices

T Kondo, W Kakegawa, M Yuzaki

EUROPEAN JOURNAL OF NEUROSCIENCE, 22(7) 1817-1820, Oct, 2005
Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses

Y Takayasu, M Iino, W Kakegawa, H Maeno, K Watase, K Wada, D Yanagihara, T Miyazaki, O Komine, M Watanabe, K Tanaka, S Ozawa

JOURNAL OF NEUROSCIENCE, 25(38) 8788-8793, Sep, 2005
Rescue of abnormal phenotypes of the delta 2 glutamate receptor-null mice by mutant delta 2 transgenes

H Hirai, T Miyazaki, W Kakegawa, S Matsuda, M Mushina, M Watanabe, M Yuzaki

EMBO REPORTS, 6(1) 90-95, Jan, 2005
Input- and subunit-specific AMPA receptor trafficking underlying long-term potentiation at hippocampal CA3 synapses

W Kakegawa, K Tsuzuki, Y Yoshida, K Kameyama, S Ozawa

EUROPEAN JOURNAL OF NEUROSCIENCE, 20(1) 101-110, Jul, 2004
Functional NMDA receptor channels generated by NMDAR2B gene transfer in rat cerebellar Purkinje cells

W Kakegawa, K Tsuzuki, M Iino, S Ozawa

EUROPEAN JOURNAL OF NEUROSCIENCE, 17(4) 887-891, Feb, 2003
Postsynaptic expression of a new calcium pathway in hippocampal CA3 neurons and its influence on mossy fiber long-term potentiation

W Kakegawa, N Yamada, M Iino, K Kameyama, T Umeda, K Tsuzuki, S Ozawa

JOURNAL OF NEUROSCIENCE, 22(11) 4312-4320, Jun, 2002
Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia

M Lino, K Goto, W Kakegawa, H Okado, M Sudo, S Ishiuchi, A Miwa, Y Takayasu, Saito, I, K Tsuzuki, S Ozawa

SCIENCE, 292(5518) 926-929, May, 2001
Sindbis viral-mediated expression of Ca2+-permeable AMPA receptors at hippocampal CA1 synapses and induction of NMDA receptor-independent long-term potentiation

T Okada, N Yamada, W Kakegawa, K Tsuzuki, M Kawamura, H Nawa, M Iino, S Ozawa

EUROPEAN JOURNAL OF NEUROSCIENCE, 13(8) 1635-1643, Apr, 2001

Misc.

【小脳学習説Marr-Albus-Ito理論の50年】小脳学習における長期抑圧(LTD)の役割

掛川渉, 松田信爾, 柚崎通介

Clinical Neuroscience, 37(8) 919-924, Aug, 2019
【記憶と忘却に関わる脳のしくみ-分子機構から健忘の症候まで】記憶・学習の分子機構そのときシナプスでは何が起きているのか

掛川渉, 柚崎通介

BRAIN and NERVE: 神経研究の進歩, 70(7) 0677-0687, Jul, 2018
【ニューロリハビリテーションの進歩】中枢神経の可塑性とは

河野まや, 掛川渉, 柚崎通介

Clinical Neuroscience, 35(5) 523-527, May, 2017
Basic Neuroscience 生化学・分子生物学「補体C1qファミリー分子」とシナプス形成・維持

掛川渉, 松田恵子, 柚崎通介

Annual Review神経, 2016 35-44, Jan, 2016
先端分析が支える次世代アミノ酸研究 D‐アミノ酸の神経生理:脳内D‐セリンによる記憶・学習制御

掛川渉, 柚崎通介

生物工学会誌, 92(12) 657-660, Dec 25, 2014

Teaching Experience

Human Life Sciences I (Gakushuin University)
Seminar in Life Science I・Ⅱ (Gakushuin University)
Frontiers of Life Science (Gakushuin University)
Graduate Research in Life Science I・Ⅱ (Gakushuin University)
Topics in Molecular and Cellular Biology Ⅱ (Gakushuin University)

Research Projects

シナプス活動変容からアプローチするアルツハイマー病発症機序の解明

科学研究費助成事業, 日本学術振興会, Apr, 2022 - Mar, 2026

渡部博貴, 堂前直, 掛川渉, 高野哲也
Comprehensively identification of molecules at synapses and non-synaptic cell-adhesion structure

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025
Naked spineから読み解く小脳シナプスの新しい形成・動作原理

Grant-in-Aid for Scientific Research, MEXT,JSPS, Apr, 2020 - Mar, 2024

掛川渉
新規ケモジェネティクス法による脳内記憶・学習回路の制御と理解

Grant-in-Aid for Scientific Research, MEXT,JSPS, Apr, 2020 - Mar, 2022

掛川渉
脳内夾雑環境で働く記憶・学習回路の新規化学遺伝学的制御

Grant-in-Aid for Scientific Research, MEXT,JSPS, Apr, 2018 - Mar, 2020

掛川渉

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