Takashi Takahashi

(高橋孝志)

Profile Information

Affiliation: Faculty of Science, Department of Chemistry, Gakushuin University

Degree: Doctor of Philosophy

J-GLOBAL ID: 200901066027301826
researchmap Member ID: 1000279064

External link: http://www.apc.titech.ac.jp/~ttakahas/

Research Areas

Nanotechnology/Materials / Synthetic organic chemistry /

Research History

Education

- 1976

Columbia University
- 1970

Department of Chemistry, Faculty of Science, Tohoku University

Committee Memberships

Awards

1984

有機合成化学協会奨励賞

Misc.

272

Total synthesis of (R)-telomestatin

Takayuki Doi, Masahito Yoshida, Kazuo Shin-ya, Takashi Takahashi

ORGANIC LETTERS, 8(18) 4165-4167, Aug, 2006
Solid-phase combinatorial synthesis of aeruginosin derivatives and their biological evaluation

Takayuki Doi, Yoichiro Hoshina, Hiroyuki Mogi, Yoshifumi Yamada, Takashi Takahashi

JOURNAL OF COMBINATORIAL CHEMISTRY, 8(4) 571-582, Jul, 2006
Stereoselective synthesis of oligo-α-(2,8)-sialic acids

Hiroshi Tanaka, Yuji Nishiura, Takashi Takahashi

Journal of the American Chemical Society, 128(22) 7124-7125, Jun 7, 2006
Stereoselective synthesis of oligo-alpha-(2,8)-sialic acids

Hiroshi Tanaka, Yuji Nishiura, Takashi Takahashi

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 128(22) 7124-7125, Jun, 2006
Glucose oxidase assisted homogeneous electrochemical receptor binding assay for drug screening

H Funabashi, Y Tanaka, Y Imamura, M Mie, T Manabe, H Tanaka, T Takahashi, H Handa, M Aizawa, E Kobatake

BIOSENSORS & BIOELECTRONICS, 21(9) 1675-1683, Mar, 2006
Total synthesis of apratoxin A

T Doi, Y Numajiri, A Munakata, T Takahashi

ORGANIC LETTERS, 8(3) 531-534, Feb, 2006
A total synthesis of spiruchostatin A

T Doi, Y Iijima, SY Kazuo, A Ganesan, T Takahashi

TETRAHEDRON LETTERS, 47(7) 1177-1180, Feb, 2006
A formal total synthesis of taxol aided by an automated synthesizer

Takayuki Doi Shinichiro Fuse, Shigeru Miyamoto, Kazuoki, Nakai Daisuke, Sasuga, Takashi Takahashi

Chem. Asian J., 1(3) 370-383, 2006
Affinity identification of delta-opioid receptors using latex nanoparticles

M Hasegawa, H Ohno, H Tanaka, M Hatakeyama, H Kawaguchi, T Takahashi, H Handa

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(1) 158-161, Jan, 2006
Synthetic study of alpha(2,8) oligosialoside using N-Troc sialyl N-phenyltrifluoroimidate

H Tanaka, Y Nishiura, M Adachi, T Takahashi

HETEROCYCLES, 67(1) 107-112, Jan, 2006
Stereoselective synthesis of oligo-alpha(2,8)-3-deoxy-D-manno-2-octulosonic acid derivatives

H Tanaka, D Takahashi, T Takahashi

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 45(5) 770-773, 2006
Stereoselective Synthesis of Oligo-α(2,8)-3-deoxy-D-manno-2-octulosonic Acid (KDO) Derivatives

Hiroshi Tanaka, Daisuke Takahashi, Takashi Takahashi

Angew. Chem., Int. Ed.,, 45(5) 770-773, 2006
Distinct layered structure with density modulation in solid phase formed from B-2 phase of banana molecules

SM Kang, M Tokita, K Ogino, T Doi, T Takahashi, H Takezoe, J Watanabe

PHYSICAL REVIEW E, 73(1) 011701, Jan, 2006
Solid-Phase Synthesis of a Combinatorial Cross-Conjugated Dienone Library and its Biological Activity

Makoto Kitade, Hiroshi Tanaka, Sho Oe, Makoto Iwashima, Kazuo Iguchi, Takashi TAKAHASHI

Chem. Eur. J., 12(5) 1368-1376, 2006
A new mechanism of methotrexate action revealed by target screening with affinity beads

Hitoshi Uga, Chikanori Kuramori, Akiko Ohta, Yasunori Tsuboi, Hiroshi Tanaka, Mamoru Hatakeyama, Yuki Yamaguchi, Takashi Takahashi, Masahiro Kizaki, Hiroshi Handa

Molecular Pharmacology, 70(5) 1832-1839, 2006
Affinity identification of δ-opioid receptors using latex nanoparticles

Makoto Hasegawa, Hiroshi Ohno, Hiroshi Tanaka, Mamoru Hatakeyama, Haruma Kawaguchi, Takashi Takahashi, Hiroshi Handa

Bioorganic and Medicinal Chemistry Letters, 16(1) 158-161, Jan 1, 2006
Efficient polymer-assisted strategy for the deprotection of protected oligosaccharides

Hiroshi Tanaka, Tadasuke Ishida, Nobuatsu Matoba, Hirokazu Tsukamoto, Haruo Yamada, Takashi Takahashi

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 45(38) 6349-6352, 2006
Distinct layered structure with density modulation in solid phase formed from B2 phase of banana molecules

Sungmin Kang, Masatoshi Tokita, Kumiko Ogino, Takayuki Doi, Takashi Takahashi, Hideo Takezoe, Junji Watanabe

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 73(1) 011701, Jan, 2006
Affinity identification of delta-opioid receptors using latex nanoparticles

M Hasegawa, H Ohno, H Tanaka, M Hatakeyama, H Kawaguchi, T Takahashi, H Handa

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(1) 158-161, Jan, 2006
Synthetic study of α(2,8) oligosialoside using N-Troc sialyl N-phenyltrifluoroimidate

Hiroshi Tanaka, Yuji Nishiura, Massatsu Adachi, Takashi Takahashi

Heterocycles, 67(1) 107-112, Jan 1, 2006
Synthesis and biological evaluation of a beauveriolide analogue library

K Nagai, T Doi, T Sekiguchi, Namatame, I, T Sunazuka, H Tomoda, S Omura, T Takahashi

JOURNAL OF COMBINATORIAL CHEMISTRY, 8(1) 103-109, Jan, 2006
Stereoselective Synthesis of Oligo-α(2,8)-3-deoxy-D-manno-2-octulosonic Acid Derivatives

Hiroshi Tanaka, Daisuke Takahashi, Takashi Takahashi

Angew. Chem., Int. Ed., 45(5) 770-773, 2006
Stereoselective Synthesis of Oligo-α(2,8)-3-deoxy-D-manno-2-octulosonic Acid (KDO) Derivatives

Hiroshi Tanaka, Daisuke Takahashi, Takashi Takahashi

Angew. Chem., Int. Ed.,, 45(5) 770-773, 2006
Distinct Layered Structure with Density Modulation in Solid Phase Formed from B2 Phase of Banana Molecules

Sungmin Kang, tokita masatoshi, Kumiko Ogino, TAKAYUKI DOI, Takashi TAKAHASHI, HIDEO TAKEZOE, junji watanabe

Physical Review E, 73(1,Pt.1) 011701, 2006
Solid-Phase Synthesis of a Combinatorial Cross-Conjugated Dienone Library and its Biological Activity

Makoto Kitade, Hiroshi Tanaka, Sho Oe, Makoto Iwashima, Kazuo Iguchi, Takashi TAKAHASHI

Chem. Eur. J., 12(5) 1368-1376, 2006
Odd-even behavior of ferroelectricity and antiferroelectricity in two homologous series of bent-core mesogens

SK Lee, S Heo, JG Lee, KT Kang, K Kumazawa, K Nishida, Y Shimbo, Y Takanishi, J Watanabe, T Doi, T Takahashi, H Takezoe

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(31) 11085-11091, Aug, 2005
Solid-supported sulfonylhydroxylamine as an effective N-aminating agent of anilines

H Ohno, H Tanaka, T Takahashi

SYNLETT, (7) 1191-1194, May, 2005
Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer

T Takahashi, K Nakai, T Doi, M Yasunaga, H Nakagawa, T Ishikawa

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 15(10) 2601-2605, May, 2005
Effective one-pot synthesis of H type 1 and 2 trisaccharide derivatives using glycal epoxide

Hiroshi Tanaka, Nobuatsu Matoba, Takashi Takahashi

Chemistry Letters, 34(3) 400-401, Mar 5, 2005
Automated parallel synthesis of a protected oligosaccharide library based upon the structure of dimeric Lewis X by one-pot sequential glycosylation

H Tanaka, N Matoba, H Tsukamoto, H Takimoto, H Yamada, T Takahashi

SYNLETT, (5) 824-828, Mar, 2005
Synthesis of the AC ring of paclitaxel: Formation of the C ring by [3+2] cycloaddition with a preformed A ring

K Nakai, T Doi, T Takahashi

SYNLETT, (5) 866-868, Mar, 2005
A library synthesis of pyrazoles by azomethine imine cycloaddition to the polymer-supported vinylsulfone

N Fuchi, T Doi, T Takahashi

CHEMISTRY LETTERS, 34(3) 438-439, Mar, 2005
Novel unsymmetrical achiral banana-shaped molecules having different lengths of alkyl terminal chains

K Ogino, SM Kang, T Doi, T Takahashi, H Takezoe, J Watanabe

CHEMISTRY LETTERS, 34(3) 450-451, Mar, 2005
Efficient stereoselective synthesis of γ-N-glycosyl asparagines by N-glycosylation of primary amide groups

Hiroshi Tanaka, Yuki Iwata, Daisuke Takahashi, Masaatsu Adachi, Takashi Takahashi

Journal of the American Chemical Society, 127(6) 1630-1631, Feb 16, 2005
Efficient stereoselective synthesis of gamma-N-glycosyl asparagines by N-glycosylation of primary amide groups

H Tanaka, Y Iwata, D Takahashi, M Adachi, T Takahashi

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(6) 1630-1631, Feb, 2005
Efficient stereoselective synthesis of gamma-N-glycosyl asparagines by N-glycosylation of primary amide groups

H Tanaka, Y Iwata, D Takahashi, M Adachi, T Takahashi

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 127(6) 1630-1631, Feb, 2005
Effective One-Pot Synthesis of H type 1 and 2 Trisaccharide Derivatives Using Glycal Epoxide

Hiroshi Tanaka, Nobuatsu Matoba, Takashi Takahashi

Chem. Lett., 34(3) 400-401, 2005
Affinity Identification of δ-Opioid Receptors Using Latex Nanoparticles

Makoto Hasegawa, Hiroshi Ohno, Hiroshi Tanaka Mamoru, Hatakeyama, Haruma Kawaguchi, Takashi Takahashi, Hiroshi Handa

Bioorg. Med. Chem. Lett., 16(1) 158-161, 2005
Synthesis of DTPA-Conjugated (1,4) Linked 2-Aminoglycosides Varying in the Anomeric Configuration and their MRI Contrast Effect

Hiroshi Tanaka, Yoshio Ando, Masatoshi Wada, Takashi Takahashi

Org. Biomol. Chem., 3(18) 3311-3328, 2005
One-Pot Synthesis of Sialo-Containing Glycosyl Amino Acids Using N-Troc β-Thiophenyl Sialoside.

Hiroshi Tanaka, Masaatsu Adachi, Takashi Takahashi

Chemistry - a Europian Journal, 11(3) 849-862, 2005
Efficient Stereoselective Synthesis of γ-N-Glycosyl Asparagines by N-Glycosylation of Primary Amide Groups

Hiroshi Tanaka, Yuki Iwata, Daisuke Takahashi, Masaatsu Adachi, Takashi Takahashi

Journal of American Chemical Society, 127(6) 1630-1631, 2005
Effective One-Pot Synthesis of H type 1 and 2 Trisaccharide Derivatives Using Glycal Epoxide

Hiroshi Tanaka, Nobuatsu Matoba, Takashi Takahashi

Chem. Lett., 34(3) 400-401, 2005
Regio- and stereocontrolled Diels-Alder reaction tethered by Asp-Thr dipeptide

T Doi, Y Miura, S Kawauchi, T Takahashi

CHEMICAL COMMUNICATIONS, (39) 4908-4910, 2005
Synthesis of DTPA-Conjugated (1,4) Linked 2-Aminoglycosides Varying in the Anomeric Configuration and their MRI Contrast Effect

Hiroshi Tanaka, Yoshio Ando, Masatoshi Wada, Takashi Takahashi

Org. Biomol. Chem., 3(18) 3311-3328, 2005
One-Pot Synthesis of Sialo-Containing Glycosyl Amino Acids Using N-Troc β-Thiophenyl Sialoside.

Hiroshi Tanaka, Masaatsu Adachi, Takashi Takahashi

Chemistry - a Europian Journal, 11(3) 849-862, 2005
Synthesis of affinity nanoparticles coupled to FR901464 derivatives

Y Imamura, Y Ohtsu, H Tanaka, M Hatakeyama, T Manabe, H Kawaguchi, H Handa, T Takahashi

HETEROCYCLES, 64 51-56, Dec, 2004
High speed parallel synthesis of banana-shaped molecules and phase transition behaviour of 4-bromo-substituted derivatives

Sungmin Kang, Jirakorn Thisayukta, Hideo Takezoe, Junji Watanabe, Kumiko Ogino, Takayuki Doi, Takashi Takahashi

Liquid Crystals, 31(10) 1323-1336, Oct, 2004
High speed parallel synthesis of banana-shaped molecules and phase transition behaviour of 4-bromo-substituted derivatives

S Kang, J Thisayukta, H Takezoe, J Watanabe, K Ogino, T Doi, T Takahashi

LIQUID CRYSTALS, 31(10) 1323-1336, Oct, 2004
Selective capture of 1 alpha,25(OH)(2)-previtamin D-3 utilizing polymer-supported trialkylsilyl triflate in the synthesis of 1 alpha,25-(OH)(2)-vitamin D-3

T Doi, M Yoshida, Hijikuro, I, T Takahashi

TETRAHEDRON LETTERS, 45(29) 5727-5729, Jul, 2004
An efficient synthesis of polymer-supported silyl linkers using a di-Grignard reagent

T Doi, M Yoshida, Hijikuro, I, T Takahashi

TETRAHEDRON LETTERS, 45(29) 5723-5726, Jul, 2004

Books and Other Publications

ラボオートメーション技術を活用したタキソールおよび9員環エンジイン化合物の合成

シーエムシー出版, 2009
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer, 2008
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer, 2008
タキソール

アイピーシー, 2007
ロボット・マイクロ合成最前線有機合成の新戦略「合成ロボットを使った天然物合成」

化学同人, 2004

Presentations

100

固相合成法を利用したヒメグルシン類の合成研究

日本化学会第90春季年会, 2010
炭素－炭素結合形成反応を用いたα－イミノカルボキサミド類縁体群の合成

日本化学会第90春季年会, 2010
光照射によりビラジカル発生が誘起される環状エンジイン化合物の合成

日本化学会第90春季年会, 2010
ラジカル環化反応を利用したピリピロペンAの合成研究

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム）, 2010
マイクロリアクターを活用した光熱異性化反応による高効率的なビタミンD3の合成

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム）, 2010

Professional Memberships

Research Projects

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