高橋 孝志

We describe a remote glycosidation that allows us to form a branched trisaccharide in intramolecular fashion. The molecular design of the spacer molecule for the remote glycosidation was examined based on molecular mechanics calculations. Copyright (C) 1996 Elsevier Science Ltd

The seco-B-ring triene system of 1 alpha,2 beta,25-trihydroxy-vitamin D3 is efficiently constructed by means of a palladium-catalyzed cyclization of the dienol triflate. (C) 1997, Elsevier Science Ltd. All rights reserved.

The stereoselective synthesis of a taxol intermediate via a biomimetic route is described. Aldol condensation of gamma-butyrolactone and citral derivatives generated three stereogenic centers at positions C1, C2, and C11 corresponding to taxol. Intramolecular alkylation of the cyanohydrin ether efficiently formed the 12-membered ring system in which stereoselective reduction, followed by directed epoxidation, afforded the key intermediate epoxide.