Takashi Takahashi

(高橋孝志)

Profile Information

Affiliation: Faculty of Science, Department of Chemistry, Gakushuin University

Degree: Doctor of Philosophy

J-GLOBAL ID: 200901066027301826
researchmap Member ID: 1000279064

External link: http://www.apc.titech.ac.jp/~ttakahas/

Research Areas

Nanotechnology/Materials / Synthetic organic chemistry /

Research History

Education

- 1976

Columbia University
- 1970

Department of Chemistry, Faculty of Science, Tohoku University

Committee Memberships

Awards

1984

有機合成化学協会奨励賞

Misc.

272

Total Synthesis of (+/-)-Smenospondiol by Titanium(III)-Mediated Tandem Radical Cyclization

Haruo Yamada, Tsuyoshi Hasegawa, Hiroshi Tanaka, Takashi Takahashi

Synlett, 1935, 2001
Synthesis of a Trisaccharide Library Using a Phenylsulfonate Traceless Linker on SynphaseTM Crowns.

Takashi Takahashi, Hitoshi Inoue, Yuichi Yamamura, Takayuki Doi

Angew. Chem. Int. Ed. Engl., 40(17) 3230-3233, 2001
Total Synthesis of (+/-)-Smenospondiol by Titanium(III)-Mediated Tandem Radical Cyclization

Haruo Yamada, Tsuyoshi Hasegawa, Hiroshi Tanaka, Takashi Takahashi

Synlett, 1935, 2001
The first synthesis of tetraglucosyl glucitol having phytoalexin-elicitor activity in rice cells based on a sequential glycosylation strategy

Toru Amaya, Hiroshi Tanaka, Takeshi Yamaguchi, Naoto Shibuya, Takashi Takahashi

Tetrahedoron Letters, 42(52) 9191-9194, 2001
Combinatorial synthesis of trisaccharides via solution-phase one-pot glycosylation

T Takahashi, M Adachi, A Matsuda, T Doi

TETRAHEDRON LETTERS, 41(15) 2599-2603, Apr, 2000
コンビナトリアルケミストリーの現状と将来

高橋孝志

化学工業, 51(2) 89-95, 2000
研究開発の効率化

高橋孝志, 佐藤忠久, 前田知子, 船津公人, 大島一史

ペトロテック, 23(11) 908-917, 2000
The Role of Polymer in Combinatorial Chemistry

TAKAHASHI Takashi, SHIMOMURA Osamu

Kobunshi, 49(11) 782-782, 2000
コンビナトリアルケミストリーの将来展望

高橋孝志, 山田晴夫

化学工学, 64(6) 269-272, 2000
21世紀の創薬を支える新技術

高橋孝志

ファルマシア, 36(1) 13-18, 2000
毒物・劇物の安全管理複数の研究室による保管室の共同利用

友岡克彦, 大谷正義, 高橋孝志

現代化学, (6) 54-58, 2000
オリゴ糖を自在につくる－ワンポットグリコシル化反応の開発

田中浩士, 高橋孝志

化学, 55(12) 66-67, 2000
Syntheses of G(M4) and G(M3) intermediates via alkylation and subsequent intramolecular glycosidation of 2-alkoxy-2-phenylthioacetate

T Takahashi, H Tsukamoto, H Yamada

ORGANIC LETTERS, 1(12) 1885-1887, Dec, 1999
Syntheses of G(M4) and G(M3) intermediates via alkylation and subsequent intramolecular glycosidation of 2-alkoxy-2-phenylthioacetate

T Takahashi, H Tsukamoto, H Yamada

ORGANIC LETTERS, 1(12) 1885-1887, Dec, 1999
Palladium(0)-catalyzed carbonylation on the multipin (TM) system

T Takahashi, H Inoue, S Tomida, T Doi, AM Bray

TETRAHEDRON LETTERS, 40(44) 7843-7846, Oct, 1999
Palladium(0)-catalyzed carbonylation on the multipin (TM) system

T Takahashi, H Inoue, S Tomida, T Doi, AM Bray

TETRAHEDRON LETTERS, 40(44) 7843-7846, Oct, 1999
One-pot sequential glycosylation: A new method for the synthesis of branched oligosaccharides

H Yamada, T Kato, T Takahashi

TETRAHEDRON LETTERS, 40(24) 4581-4584, Jun, 1999
Glycosidation of solid-supported glycosyl donors tethered by a trialkylsilane linker

T Doi, M Sugiki, H Yamada, T Takahashi, JA Porco

TETRAHEDRON LETTERS, 40(11) 2141-2144, Mar, 1999
A Novel Method for the Stereoselective Formation of Trans Bicyclic Ketones by Way of Oxidative Radical Cyclization

T. Takahashi, S. Tomida, T. Doi

Synlett, (5) 644-646, 1999
セリンプロテアーゼ阻害剤を指向したペプチドミメティックのデザイン・合成・ライブラリー化

高橋孝志, 渕信寛, 土井隆行, MichaelKahn

第9回コンビナトリアル化学研究会公開セミナー要旨集, 31-33, 1999
コンビナトリアルケミストリーと固相有機合成

高橋孝志, 土黒一郎

アロマティックス, 51(11/12) 438-444, 1999
総論－コンビナトリアルケミストリー

高橋孝志

ファインケミカル, 28(18) 5-6, 1999
コンビナトリアルケミストリーと機能性物質の合成研究

高橋孝志, 土井隆行

ファインケミカル, 28(18) 7-13, 1999
An Efficient Solid-Phase Synthesis of the Vitamin D_3_ System

T. Doi, I. Hijikuro, T. Takahashi

J.Am.Chem. Soc., 121(28) 6749-6750, 1999
New Approach to the Steroid BCD-Ring System by Utilizing a Tandem Transannular Radical Cyclization

S. Tomida, T. Doi, T. Takahashi

Teterahedron Lett., 40(12) 2363-2366, 1999
A Novel Strategy for an Automated Synthesis of Bis-Amides of 1,2- Diamines.

Takayuki Doi Ichiro Hijikuro, Takashi Takahash

Synlett, (11) 1751-1753, 1999
A Novel Method for the Stereoselective Formation of Trans Bicyclic Ketones by Way of Oxidative Radical Cyclization

T. Takahashi, S. Tomida, T. Doi

Synlett, (5) 644-646, 1999
An Efficient Solid-Phase Synthesis of the Vitamin D_3_ System

T. Doi, I. Hijikuro, T. Takahashi

J.Am.Chem. Soc., 121(28) 6749-6750, 1999
New Approach to the Steroid BCD-Ring System by Utilizing a Tandem Transannular Radical Cyclization

S. Tomida, T. Doi, T. Takahashi

Teterahedron Lett., 40(12) 2363-2366, 1999
A Novel Strategy for an Automated Synthesis of Bis-Amides of 1,2- Diamines.

Takayuki Doi Ichiro Hijikuro, Takashi Takahash

Synlett, (11) 1751-1753, 1999
DNA cleaving activities of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties

T Takahashi, H Tanaka, A Matsuda, T Doi, H Yamada, T Matsumoto, D Sasaki, Y Sugiura

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 8(23) 3303-3306, Dec, 1998
Synthesis of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties

T Takahashi, H Tanaka, A Matsuda, T Doi, H Yamada

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 8(23) 3299-3302, Dec, 1998
Recent progress in syntheses of 9-membered masked enediyne analogues and their DNA cleaving activities

T Takahashi, H Tanaka, T Doi, H Yamada

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 56(11) 987-999, Nov, 1998
Nucleophilic substitutions on Multipin (TM) systems linked with a traceless linker

T Takahashi, S Tomida, H Inoue, T Doi

SYNLETT, (11) 1261-+, Nov, 1998
Solid phase approach to muscone synthesis: Rh(I)-catalyzed hydroformylation of a 1,1-disubstituted alkene on the multipin (TM) system

T Takahashi, S Ebata, T Doi

TETRAHEDRON LETTERS, 39(11) 1369-1372, Mar, 1998
エイジイン分子と糖の合成で人工制限酵素開発の道筋をつくる

高橋孝志

日経サイエンス, 28(11) 106-106, 1998
One-Pot Sequential Asymmetric Hydrogenation Utilizing Rh(I)- and Ru(II)-Catalysts

T. Doi, M. Kokubo, K, Yamamoto, T. Takahashi

J. Org. Chem., 63(3) 428-429, 1998
Palladium(0)-Catalyzed Domino Cyclization-Carbonylation of Alkenyl-Allenyl Acetate

T. Doi, M, Takasaki, S. Nakanishi, A. Yanagisawa, K. Yamamoto, T. Takahashi

Bull. Chem. Soc. Jpn., 71(12) 2929-2935, 1998
Synthesis of the Chiral CD Rings of Paclitaxel from 2-Deoxy-D-ribose: Novel 1,2-Addition of a Dienolate to a Chiral Ketone

T. Takahashi, Y. Hirose, H. Iwamoto, T. Doi

J. Org. Chem., 63(17) 5742-5743, 1998
コンビナトリアルケミストリーの有機合成における新展開

高橋孝志, 土井隆行

現代化学, 332(56) 61, 1998
Design and synthesis of a water-soluble taxol analogue: Taxol-sialyl conjugate

T Takahashi, H Tsukamoto, H Yamada

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 8(1) 113-116, Jan, 1998
A synthetic approach towards the identification of periplaneta sex pheromones

H Iwamoto, T Harada, T Takahashi, S Takahashi

HETEROCYCLES, 47(1) 139-142, Jan, 1998
One-Pot Sequential Asymmetric Hydrogenation Utilizing Rh(I)- and Ru(II)-Catalysts

T. Doi, M. Kokubo, K, Yamamoto, T. Takahashi

J. Org. Chem., 63(3) 428-429, 1998
Palladium(0)-Catalyzed Domino Cyclization-Carbonylation of Alkenyl-Allenyl Acetate

T. Doi, M, Takasaki, S. Nakanishi, A. Yanagisawa, K. Yamamoto, T. Takahashi

Bull. Chem. Soc. Jpn., 71(12) 2929-2935, 1998
Synthesis of the Chiral CD Rings of Paclitaxel from 2-Deoxy-D-ribose: Novel 1,2-Addition of a Dienolate to a Chiral Ketone

T. Takahashi, Y. Hirose, H. Iwamoto, T. Doi

J. Org. Chem., 63(17) 5742-5743, 1998
Recent Progress in Syntheses of 9-Membered Masked Enediyne Analogues and their DNA Cleaving Activities

Takashi Takahashi, Hiroshi Tanaka, Takayuki Doi, Haruo Yamada

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 56(11) 987-999, 1998
New route to 3-deoxy-2-ulosonic acids; total synthesis of KDO and KDN

Hirokazu Tsukamoto, Takashi Takahashi

Tetrahedron Letters, 38(36) 6415-6418, Sep 8, 1997
Total synthesis of Neu5Ac via alkylation of 2-alkoxy-2-cyanoacetate with a sugar-derived bromide

T Takahashi, H Tsukamoto, M Kurosaki, H Yamada

SYNLETT, (9) 1065-1066, Sep, 1997
New route to 3-deoxy-2-ulosonic acids; Total syntheses of KDO and KDN

H Tsukamoto, T Takahashi

TETRAHEDRON LETTERS, 38(36) 6415-6418, Sep, 1997
Synthesis of taxoid ring systems: AC->ABC approach by way of intramolecular alkylation

T Takahashi, H Iwamoto, K Nagashima, T Okabe, T Doi

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 36(12) 1319-1321, Jul, 1997

Books and Other Publications

ラボオートメーション技術を活用したタキソールおよび9員環エンジイン化合物の合成

シーエムシー出版, 2009
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer, 2008
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer, 2008
タキソール

アイピーシー, 2007
ロボット・マイクロ合成最前線有機合成の新戦略「合成ロボットを使った天然物合成」

化学同人, 2004

Presentations

100

固相合成法を利用したヒメグルシン類の合成研究

日本化学会第90春季年会, 2010
炭素－炭素結合形成反応を用いたα－イミノカルボキサミド類縁体群の合成

日本化学会第90春季年会, 2010
光照射によりビラジカル発生が誘起される環状エンジイン化合物の合成

日本化学会第90春季年会, 2010
ラジカル環化反応を利用したピリピロペンAの合成研究

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム）, 2010
マイクロリアクターを活用した光熱異性化反応による高効率的なビタミンD3の合成

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム）, 2010

Professional Memberships

Research Projects

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