Curriculum Vitaes

Takashi Takahashi

(高橋孝志)

Profile Information

Affiliation: Faculty of Science, Department of Chemistry, Gakushuin University

Degree: Doctor of Philosophy

J-GLOBAL ID: 200901066027301826
researchmap Member ID: 1000279064

External link: http://www.apc.titech.ac.jp/~ttakahas/

Research Areas

1

Nanotechnology/Materials / Synthetic organic chemistry /

Research History

7

Education

2

- 1976

Columbia University
- 1970

Department of Chemistry, Faculty of Science, Tohoku University

Committee Memberships

4

Awards

1

1984

有機合成化学協会奨励賞

Misc.

272

FR225659-binding Proteins: Identification as Serine/Threonine Protein Phosphatase PP1 and PP2A Using High-performance Affinity Beads

Hidetaka Hatori, Tatsuya Zenkoh, Motoo Kobayashi, Yoshihiro Ohtsu, Hiroshi Tanaka, Nobuharu Shigematsu, Hiroyuki Setoi, Motohiro Hino, Haruma Kawaguchi, Takashi Takahashi, Hiroshi Handa

J. Antibiotics, 57(7) 456-461, 2004
Total synthesis of macrosphelide A by way of palladium-catalyzed carbonylative esterification

S Kusaka, S Dohi, T Doi, T Takahashi

TETRAHEDRON LETTERS, 44(49) 8857-8859, Dec, 2003
Efficient solid-phase synthesis of symmetric norbinaltorphimine derivatives

H Tanaka, M Moriwaki, T Takahashi

ORGANIC LETTERS, 5(21) 3807-3809, Oct, 2003
Solid phase library synthesis of cyclic depsipeptides: Aurilide and aurilide analogues

T Takahashi, H Nagamiya, T Doi, PG Griffiths, AM Bray

JOURNAL OF COMBINATORIAL CHEMISTRY, 5(4) 414-428, Jul, 2003
Parallel synthesis of multi-branched oligosaccharides related to elicitor active pentasaccharide in rice cell based on orthogonal deprotection and glycosylation strategy

Hiroshi Tanaka, Toru Amaya, Takashi Takahashi

Tetrahedron Letters, 44(15) 3053-3057, Apr 7, 2003
Solid-phase synthesis of naltrindole derivatives using Fischer indole synthesis based on one-pot release and cyclization methodology

H Tanaka, H Ohno, K Kawamura, A Ohtake, H Nagase, T Takahashi

ORGANIC LETTERS, 5(8) 1159-1162, Apr, 2003
Palladium(0)-catalyzed Mizoroki-Heck reaction and Rh(I)-catalyzed asymmetric hydrogenation of polymer-supported dehydroalanine system

T Doi, N Fujimoto, J Watanabe, T Takahashi

TETRAHEDRON LETTERS, 44(10) 2161-2165, Mar, 2003
Synthesis of a new troponoid liquid crystalline library on solid support

M Hashimoto, A Mori, H Inoue, H Nagamiya, T Doi, T Takahashi

TETRAHEDRON LETTERS, 44(6) 1251-1254, Feb, 2003
Parallel Synthesis of Multi-branched Oligosaccharides Related to Elicitor Active Pentasaccharide in Rice Cell Based on Orthogonal Deprotection and Glycosylation Strategy

Hiroshi Tanaka, Toru Amaya, Takashi Takahashi

Tetrahedron letter, 44(15) 3053-3057, 2003
A Combinatorial Synthesis of a Macrosphelide Library Utilizing a Palladium-Catalyzed Carbonylation on a Polymer Support.

Takashi Takahashi, Shin-ichi Kusaka, Takayuki Doi, Toshiaki Sunazuka, Satoshi Omura

Angew. Chem. Int. Ed., 42(42) 5230-5234, 2003
Parallel Synthesis of Multi-branched Oligosaccharides Related to Elicitor Active Pentasaccharide in Rice Cell Based on Orthogonal Deprotection and Glycosylation Strategy

Hiroshi Tanaka, Toru Amaya, Takashi Takahashi

Tetrahedron Lett., 44(15) 3053-3057, 2003
蛍光相関分光法を用いる糖鎖－蛋白質相互作用解析法の開発

山田純史, 田中浩士, 川南三郎, 石田匡祐, 長野隆, 高橋孝志

第26回日本分子生物学会年会要旨集, 2003
カルボニル化ー環化反応を用いる環状ペプチドライブラリーの構築法の開発

大野宏, 川村邦昭, 大竹淳之, 長瀬博, 田中浩士, 高橋孝志土井隆行, 上岡正児, 島津さやか, 高橋孝志

第4０回ペプチド討論会講演要旨集, 12, 2003
天然物の母骨格を有する化合物ライブラリーの構築 :マクロスフェライド誘導体のコンビナトリアル合成

日下真一, 土肥卓, 土井隆行, 高橋孝志

第45回天然有機化合物討論会講演要旨集, 233-238, 2003
連続的環化グリコシル化反応を用いた2-デオキシ糖およびKDO含有糖鎖の合成研究

高橋大介, 雨夜徹, 田中浩士, 高橋孝志

第24回日本糖質学会年会要旨集, 23, 2003
天然物の母骨格を有する化合物ライブラリーの構築 : ワンポットグリコシル化反応を用いるルイスX誘導体のコンビナトリアル合成

的場宣篤, 塚本裕一, 田中浩士, 高橋孝志

第84回有機合成シンポジウム講演要旨集, 84-85, 2003
固相合成を用いたインドールオピオイド化合物のライブラリー構築

大野宏, 川村邦昭, 大竹淳之, 長瀬博, 田中浩士, 高橋孝志

第84回有機合成シンポジウム講演要旨集, 76-77, 2003
ワンポットグリコシル化反応を用いたシアル酸含有O-結合型糖アミノ酸ユニットの合成研究

安立昌篤, 田中浩士, 高橋孝志

第17回Combinatrial Chemistry研究会要旨集, 37-40, 2003
Synthesis of 2,3,6-Trideoxysugar-Containing Disaccharides by Cyclization and Glycosidation throuth the Sequential Activation of Sulfoxide and Methylsulfanyl Groups in a One-pot Procedure.

Toru Amaya, Daisuke Takahashi, Hiroshi Tanaka, Takashi Takahashi

Angew. Chem. Int. Ed. Engl., 42(16) 1833-1836, 2003
最近の創薬研究と大学発ベンチャー企業の紹介

高橋孝志, 菅原

Medchem News, 13(3) 2-6, 2003
The Synthesis of Disaccharides Containing a 2,3,6-Trideoxysugar by Cyclization and Glycosidation Based on the Sequential Activation of Sulfoxide and Methylthio Groups in a One-pot Procedure

Amaya Toru, Daisuke Takahashi, Hiroshi Tanaka, Takashi Takahashi

Angewante Chemistry, International Edition, 42(16) 1833-1836, 2003
A Combinatorial Synthesis of a Macrosphelide Library Utilizing a Palladium-Catalyzed Carbonylation on a Polymer Support.

Takashi Takahashi, Shin-ichi Kusaka, Takayuki Doi, Toshiaki Sunazuka, Satoshi Omura

Angew. Chem. Int. Ed., 42(42) 5230-5234, 2003
Parallel Synthesis of Multi-branched Oligosaccharides Related to Elicitor Active Pentasaccharide in Rice Cell Based on Orthogonal Deprotection and Glycosylation Strategy

Hiroshi Tanaka, Toru Amaya, Takashi Takahashi

Tetrahedron Lett., 44(15) 3053-3057, 2003
Synthesis of 2,3,6-Trideoxysugar-Containing Disaccharides by Cyclization and Glycosidation throuth the Sequential Activation of Sulfoxide and Methylsulfanyl Groups in a One-pot Procedure.

Toru Amaya, Daisuke Takahashi, Hiroshi Tanaka, Takashi Takahashi

Angew. Chem. Int. Ed. Engl., 42(16) 1833-1836, 2003
The Synthesis of Disaccharides Containing a 2,3,6-Trideoxysugar by Cyclization and Glycosidation Based on the Sequential Activation of Sulfoxide and Methylthio Groups in a One-pot Procedure

Amaya Toru, Daisuke Takahashi, Hiroshi Tanaka, Takashi Takahashi

Angewante Chemistry, International Edition, 42(16) 1833-1836, 2003
Synthesis of di-branched heptasaccharide by one-pot glycosylation using seven independent building blocks

H Tanaka, M Adachi, H Tsukamoto, T Ikeda, H Yamada, T Takahashi

ORGANIC LETTERS, 4(24) 4213-4216, Nov, 2002
Solid-phase synthesis of 2-(4-carbamoylpyrazolyl)-4-alkylamino-6-aminopyrimidine derivatives

M Haruta, A Ejima, H Tanaka, T Takahashi

HETEROCYCLES, 58 79-83, Nov, 2002
Solid-phase synthesis of beta-mono-substituted ketones and an application to the synthesis of a library of phlorizin derivatives

H Tanaka, T Zenkoh, H Setoi, T Takahashi

SYNLETT, (9) 1427-1430, Sep, 2002
Solid-phase synthesis of a phytoalexin elicitor-active tetraglucosyl glucitol

T Takahashi, A Okano, T Amaya, H Tanaka, T Doi

SYNLETT, (6) 911-914, Jun, 2002
Synthesis of a tetrabenzyl-substituted 10-membered cyclic diamide

T Doi, H Nagamiya, M Kokubo, K Hirabayashi, T Takahashi

TETRAHEDRON, 58(15) 2957-2963, Apr, 2002
The Solid-Phase Parallel Synthesis of beta-Strand mimetic Template via 1,3-dipolar Cyclization with Resin-bound Vinylsulfone.

Nobuhiro Fuchi, TakayukiDoi Bolong, Cao Michael Kahn, Takashi Takahashi

Synlett, (2) 285-289, 2002
シリルリンカーを用いた糖ハイブリッド９員環エンジインライブラリーの固相合成法に関する研究

高橋孝志, 田中浩士

有合化, 60(5) 490-491, 2002
コンビナトリアルケミストリー

高橋孝志, 土井隆行

有合化, 60(5) 426-433, 2002
Solid-Phase Synthesis of Aryl O-Glycoside Using Aqueous Base and Phase-Transfer Catalyst

Tatsuya Zenkoh, Hiroshi Tanaka, Hiroyuki Setoi, Takashi Takahashi

Synlett, 867-870, 2002
Solid-Phase Synthesis of a Phytoalexin Elicitor-Active Tetraglucosyl Glucitol

Takashi Takahashi, Akihiro Okano, Toru Amaya, Hiroshi Tanaka, Takayuki Doi

Synlett, 911-914, 2002
The Solid-Phase Parallel Synthesis of beta-Strand mimetic Template via 1,3-dipolar Cyclization with Resin-bound Vinylsulfone.

Nobuhiro Fuchi, TakayukiDoi Bolong, Cao Michael Kahn, Takashi Takahashi

Synlett, (2) 285-289, 2002
Synthesis of the ABC ring system of paclitaxel: Formation of the 8-membered B ring by intramolecular alkylation

S Miyamoto, T Doi, T Takahashi

SYNLETT, (1) 97-99, Jan, 2002
Solid-Phase Synthesis of 2-(Carbamoylpyrazolyl)-4-Alkylamino-6-Aminopyrimidine Derivatives

Makoto Haruta, Akio Ejima, Hiroshi Tanaka, Takashi Takahashi

Heterocycles, 58 79-83, 2002
Solid-Phase Synthesis of Aryl O-Glycoside Using Aqueous Base and Phase-Transfer Catalyst

Tatsuya Zenkoh, Hiroshi Tanaka, Hiroyuki Setoi, Takashi Takahashi

Synlett, 867-870, 2002
Solid-phase synthesis of 6-sulfonylamino morphinan libraries

H Ohno, K Kawamura, A Otake, H Nagase, H Tanaka, T Takahashi

SYNLETT, (1) 93-96, Jan, 2002
The first synthesis of tetraglucosyl glucitol having phytoalexin-elicitor activity in rice cells based on a sequential glycosylation strategy

Toru Amaya, Hiroshi Tanaka, Takeshi Yamaguchi, Naoto Shibuya, Takashi Takahashi

Tetrahedron Letters, 42(52) 9191-9194, Dec 24, 2001
The first synthesis of tetraglucosyl glucitol having phytoalexin-elicitor activity in rice cells based on a sequential glycosylation strategy

T Amaya, H Tanaka, T Yamaguchi, N Shibuya, T Takahashi

TETRAHEDRON LETTERS, 42(52) 9191-9194, Dec, 2001
Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: synthesis of the A and C ring synthons of paclitaxel

K Nakai, M Kamoshita, T Doi, H Yamada, T Takahashi

TETRAHEDRON LETTERS, 42(44) 7855-7857, Oct, 2001
The synthesis of the CD ring of paclitaxel

K Nakai, S Miyamoto, D Sasuga, T Doi, T Takahashi

TETRAHEDRON LETTERS, 42(44) 7859-7862, Oct, 2001
Parallel synthesis of oligosaccharide conjugated enediynes onto silyl-linked solid-support

A Matsuda, T Doi, H Tanaka, T Takahashi

SYNLETT, (7) 1101-1104, Jul, 2001
Parallel synthesis of a vitamin D-3 library in the solid-phase

Hijikuro, I, T Doi, T Takahashi

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 123(16) 3716-3722, Apr, 2001
The synthesis of beta-strand mimetic templates via regioselective 1,3-dipolar cycloaddition with vinylsulfone

N Fuchi, T Doi, T Harada, J Urban, BL Cao, M Kahn, T Takahashi

TETRAHEDRON LETTERS, 42(7) 1305-1308, Feb, 2001
Synthesis of a Trisaccharide Library Using a Phenylsulfonate Traceless Linker on SynphaseTM Crowns.

Takashi Takahashi, Hitoshi Inoue, Yuichi Yamamura, Takayuki Doi

Angew. Chem. Int. Ed. Engl., 40(17) 3230-3233, 2001
コンビナトリアルケミストリーの化学工業への応用

高橋孝志

ケミカルエンジニアリング, 46(8) 613-618, 2001
創薬におけるコンビナトリアルケミストリーの現状と将来

高橋孝志

日病薬誌, 37(3) 5356-5367, 2001

Books and Other Publications

12

ラボオートメーション技術を活用したタキソールおよび9員環エンジイン化合物の合成

シーエムシー出版, 2009
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer, 2008
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer, 2008
タキソール

アイピーシー, 2007
ロボット・マイクロ合成最前線有機合成の新戦略「合成ロボットを使った天然物合成」

化学同人, 2004

Presentations

100

固相合成法を利用したヒメグルシン類の合成研究

日本化学会第90春季年会, 2010
炭素－炭素結合形成反応を用いたα－イミノカルボキサミド類縁体群の合成

日本化学会第90春季年会, 2010
光照射によりビラジカル発生が誘起される環状エンジイン化合物の合成

日本化学会第90春季年会, 2010
ラジカル環化反応を利用したピリピロペンAの合成研究

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム）, 2010
マイクロリアクターを活用した光熱異性化反応による高効率的なビタミンD3の合成

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム）, 2010

Professional Memberships

7

Research Projects

6

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