Takashi Takahashi

(高橋孝志)

Profile Information

Affiliation: Faculty of Science, Department of Chemistry, Gakushuin University

Degree: Doctor of Philosophy

J-GLOBAL ID: 200901066027301826
researchmap Member ID: 1000279064

External link: http://www.apc.titech.ac.jp/~ttakahas/

Research Areas

Nanotechnology/Materials / Synthetic organic chemistry /

Research History

Education

- 1976

Columbia University
- 1970

Department of Chemistry, Faculty of Science, Tohoku University

Committee Memberships

Awards

1984

有機合成化学協会奨励賞

Misc.

272

Design and synthesis of a solid-supported FR225659 derivative for its receptor screening

T Zenkoh, H Hatori, H Tanaka, M Hasegawa, M Hatakeyama, Y Kabe, H Setoi, H Kawaguchi, H Handa, T Takahashi

ORGANIC LETTERS, 6(14) 2477-2480, Jul, 2004
Efficient solid-phase synthesis of clavulones via sequential coupling of alpha- and omega-chains

H Tanaka, T Hasegawa, M Iwashima, K Iguchi, T Takahashi

ORGANIC LETTERS, 6(7) 1103-1106, Apr, 2004
Efficient solid-phase synthesis of clavulones via sequential coupling of alpha- and omega-chains

H Tanaka, T Hasegawa, M Iwashima, K Iguchi, T Takahashi

ORGANIC LETTERS, 6(7) 1103-1106, Apr, 2004
Effective irreversible alkylating reagents based on the structure of clavulones

Hiroshi Tanaka, Makoto Kitade, Makoto Iwashima, Kazuo Iguchi, Takashi Takahashi

Bioorganic and Medicinal Chemistry Letters, 14(4) 837-840, Feb 23, 2004
Ti(III)-catalyzed radical cyclization of 6,7-epoxygeranyl acetate

Shinichiro Fuse, Malcoln Hanochi, Takayuki Doi, Takashi Takahashi

Tetrahedron Letters, 45(9) 1961-1963, Feb 23, 2004
Efficient synthesis of core 2 class glycosyl amino acids by one-pot glycosylation approach

Hiroshi Tanaka, Masaatsu Adachi, Takashi Takahashi

Tetrahedron Letters, 45(7) 1433-1436, Feb 9, 2004
Combinatorial synthesis of carbohydrate cluster on tree-type linker with orthogonally cleavable parts

T Amaya, H Tanaka, T Takahashi

SYNLETT, (3) 497-502, Feb, 2004
Solid-phase synthesis of carbohydrate cluster on tree-type linker with three types of orthogonally cleavable part

T Amaya, H Tanaka, T Takahashi

SYNLETT, (3) 503-507, Feb, 2004
Efficient synthesis of core 2 class glycosyl amino acids by one-pot glycosylation approach

H Tanaka, M Adachi, T Takahashi

TETRAHEDRON LETTERS, 45(7) 1433-1436, Feb, 2004
Ti(III)-catalyzed radical cyclization of 6,7-epoxygeranyl acetate

S Fuse, M Hanochi, T Doi, T Takahashi

TETRAHEDRON LETTERS, 45(9) 1961-1963, Feb, 2004
Effective irreversible alkylating reagents based on the structure of clavulones

H Tanaka, M Kitade, M Iwashima, K Iguchi, T Takahashi

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 14(4) 837-840, Feb, 2004
Solid-phase synthesis of N-alkylated naltrindoles using a 3-nitrobenzyl safety-catch linker

H Ohno, H Tanaka, T Takahashi

SYNLETT, (3) 508-511, Feb, 2004
研究室紹介

高橋研究室

Organo Metallic News, (1) 19-20, 2004
Efficient Solid-Phase Synthesis of Clavulones via Sequential Coupling of α- and ω-Chains.

Hiroshi Tanaka, Tsuyoshi Hasegawa Makoto Iwashima, Kazuo Iguchi, Takashi Takahashi

Org. Lett., 6(7) 1103-1106, 2004
Design and Synthesis of a Solid-Supported FR225659 Derivative for Its Receptor Screening

Tatsuya Zenkoh, Hidetaka Hatori, Hiroshi Tanaka Makoto, Hasegawa, Mamoru Hatakeyama, Yasuaki Kabe, Hiroyuki Setoi, Haruma Kawaguchi, Hiroshi Handa Takashi

Org. Lett., 6(14) 2477-2480, 2004
One-Pot Synthesis of Sialo-Containing Glycosyl Amino Acids Using N-Troc β-Thiophenyl Sialoside.

Hiroshi Tanaka, Masaatsu Adachi, Takashi Takahashi

Chem.-Eur. J., 11(3) 849-862, 2004
天然物の母骨格を有する化合物ライブラリーの構築：Aeruginosin誘導体のコンビナトリアル合成

星名洋一郎, 茂木寛幸, 土井隆行, 田中浩士, 山田純史, 長野隆, 高橋孝志

第18回Combinatrial Chemistry研究会要旨集, 34, 2004
対称型および非対称型ノルビナルトルフィミンライブラリーの固相合成

森脇光博, 田中浩士, 高橋孝志

第18回Combinatrial Chemistry研究会要旨集, 43, 2004
αおよびβ（1，4）オリゴアミノ糖鎖を有するMRI用Gd系造影剤の合成とその評価

安藤吉勇, 田中浩士, 和田真利, 高橋孝志

第８５回有機合成シンポジウム講演要旨集, 61, 2004
Combinatorial Synthesis of Natural Products:A Library Synthesis of Macrosphelide Using Polymer-Support

Takashi Takahashi, Shin-ichi Kusaka, Takayuki Doi, Toshiaki Sunazuka, Satoshi Omura

IUPAC ICOS-15 Conference Program and Abstracts, 392, 2004
Solid-Phase Synthesis of Combinatorial Symmetric and Asymmetric Norbinaltorphimine Libraries

Hiroshi Tanaka, Mitsuhiro Moriwaki, Takashi Takahashi

IUPAC ICOS-15 Conference Program and Abstracts, 393, 2004
MRI造影効果を有するオリゴキトサン誘導体の合成とその機能評価

安藤吉勇, 田中浩士, 和田真利, 高橋孝志

キチン・キトサン研究, 10(2) 178, 2004
直接的N-グリコシル化反応を用いたN-結合型糖ペプチドの合成研究

田中浩士, 岩田由紀, 高橋大介, 安立昌篤, 高橋孝志

第19回Combinatrial Chemistry研究会要旨集, 42, 2004
糖新生阻害剤ＦＲ２２５６５９のライブラリー構築とその標的蛋白質の探索

田中浩士, 善光龍哉, 羽鳥英孝, 小林幹央, 長谷川慎, 畠山士, 瀬戸井宏行, 日野資弘, 川口春馬, 半田宏, 高橋孝志

第19回Combinatrial Chemistry研究会要旨集, 109, 2004
マクロファージ泡沫化阻害活性を有するボーベリオライド類のライブラリー合成と活性評価

長井賢一郎, 砂塚敏明, 供田洋, 大村智, 生田目一寿, 関口尊文, 藤本伸明, 土井隆行, 高橋孝志

第46回天然有機化合物討論会講演要旨集, 31, 2004
ワンポットグリコシル化反応を用いる生理活性糖鎖（ダイメリックルイスＸおよびシアル酸含有糖アミノ酸）の高速合成法の開発

田中浩士, 的場宣篤, 安立昌篤, 塚本裕一, 高橋孝志

第46回天然有機化合物討論会講演要旨集, 166, 2004
Combinatorial Synthesis of Natural Products : Automated Parallel Synthesis of Dimeric Lewis X Library by One-Pot Sequential Glycosylation

Takashi Takahashi, Nobuatsu Matoba, Hirokazu Tsukamoto, Hisami Takimoto, Hiroshi Tanaka

Glycobiology, 14(11) 1089, 2004
Development of Glycoarray having the Functionalized Oligosaccharides toward the Chemical Genomics

Daisuke Takahashi, Hiroshi Tanaka, Takashi Takahashi

Glycobiology, 14(11) 1203, 2004
Combinatorial Synthesis of DTPA-Conjugated Oligosaccharides as MRI Contrast Agents

Yoshio Ando, Hiroshi Tanaka, Masatoshi Wada, Takashi Takahashi

Glycobiology, 14(11) 1079, 2004
Efficient Stereoselective Synthesis of N-Linked Glycopeptides by N-Glycosylation of Primary Amide Groups

Hiroshi Tanaka, Yuki Iwata, Daisuke Takahashi, Masaatsu Adachi, Takashi Takahashi

Glycobiology, 14(11) 1088, 2004
LA（ラボオートメーション）導入による有機合成の効率化を指向したタキソールの全合成研究

布施新一郎, 宮本滋, 中井一宙, 土井隆行, 高橋孝志

第86回有機合成シンポジウム講演要旨集, 80, 2004
π‐アリルパラジウム錯体に対する分子内アルケン挿入反応を用いたジメチルグロイオシホンAの全合成研究

飯島悠介, 高崎優, 土井隆行, 高橋孝志

第86回有機合成シンポジウム講演要旨集, 2004
1st Asia-Pacific International Peptide Symposium: 41st Japanese Peptide Symposium (APIPS-JPS 2004)

Takayuki Doi Yuko Miura, Susumu Kawauchi, Takashi Takahashi

Novel Regio- and Stereo-controlled Diels-Alder Reaction Tethered by Dipeptide, 2004
ラボオートメーションと天然物合成

高橋孝志

日本プロセス化学 2004ウインターシンポジウム講演要旨集, 30-37, 2004
合成ロボットを使った天然物合成

高橋孝志, 布施新一郎

化学フロンティア, 14 66, 2004
Effective sialylation method using N-Troc and N-Fmoc β-phenyl thiosialosides and an application to the one-pot two-step synthesis of 2,6-STF Antigen

Masaatsu Adachi, Hiroshi Tanaka, Takashi Takahashi

Synlett, 609-614, 2004
FR225659-binding Proteins: Identification as Serine/Threonine Protein Phosphatase PP1 and PP2A Using High-performance Affinity Beads

Hidetaka Hatori, Tatsuya Zenkoh, Motoo Kobayashi, Yoshihiro Ohtsu, Hiroshi Tanaka, Nobuharu Shigematsu, Hiroyuki Setoi, Motohiro Hino, Haruma Kawaguchi, Takashi Takahashi, Hiroshi Handa

J. Antibiotics, 57(7) 456-461, 2004
Combinatorial library synthesis of two- and three-ring benzenoid amides on solid support

A Mori, Akahoshi, I, M Hashimoto, T Doi, T Takahashi

TETRAHEDRON LETTERS, 45(4) 813-815, Jan, 2004
Design and Synthesis of a Solid-Supported FR225659 Derivative for Its Receptor Screening

Tatsuya Zenkoh, Hidetaka Hatori, Hiroshi Tanaka Makoto, Hasegawa, Mamoru Hatakeyama, Yasuaki Kabe, Hiroyuki Setoi, Haruma Kawaguchi, Hiroshi Handa Takashi

Org. Lett., 6(14) 2477-2480, 2004
One-Pot Synthesis of Sialo-Containing Glycosyl Amino Acids Using N-Troc β-Thiophenyl Sialoside.

Hiroshi Tanaka, Masaatsu Adachi, Takashi Takahashi

Chem.-Eur. J., 11(3) 849-862, 2004
Combinatorial Synthesis of Natural Products:A Library Synthesis of Macrosphelide Using Polymer-Support

Takashi Takahashi, Shin-ichi Kusaka, Takayuki Doi, Toshiaki Sunazuka, Satoshi Omura

IUPAC ICOS-15 Conference Program and Abstracts, 392, 2004
Solid-Phase Synthesis of Combinatorial Symmetric and Asymmetric Norbinaltorphimine Libraries

Hiroshi Tanaka, Mitsuhiro Moriwaki, Takashi Takahashi

IUPAC ICOS-15 Conference Program and Abstracts, 393, 2004
Combinatorial Synthesis of Natural Products : Automated Parallel Synthesis of Dimeric Lewis X Library by One-Pot Sequential Glycosylation

Takashi Takahashi, Nobuatsu Matoba, Hirokazu Tsukamoto, Hisami Takimoto, Hiroshi Tanaka

Glycobiology, 14(11) 1089, 2004
Development of Glycoarray having the Functionalized Oligosaccharides toward the Chemical Genomics

Daisuke Takahashi, Hiroshi Tanaka, Takashi Takahashi

Glycobiology, 14(11) 1203, 2004
Combinatorial Synthesis of DTPA-Conjugated Oligosaccharides as MRI Contrast Agents

Yoshio Ando, Hiroshi Tanaka, Masatoshi Wada, Takashi Takahashi

Glycobiology, 14(11) 1079, 2004
Efficient Stereoselective Synthesis of N-Linked Glycopeptides by N-Glycosylation of Primary Amide Groups

Hiroshi Tanaka, Yuki Iwata, Daisuke Takahashi, Masaatsu Adachi, Takashi Takahashi

Glycobiology, 14(11) 1088, 2004
1st Asia-Pacific International Peptide Symposium: 41st Japanese Peptide Symposium (APIPS-JPS 2004)

Takayuki Doi Yuko Miura, Susumu Kawauchi, Takashi Takahashi

Novel Regio- and Stereo-controlled Diels-Alder Reaction Tethered by Dipeptide, 2004
Combinatorial synthesis of carbohydrate cluster on tree-type linker with orthogonally cleavable parts

Toru Amaya, Hiroshi Tanaka, Takashi Takahashi

Synlett, 497-502, 2004
Solid-phase synthesis of carbohydrate cluster on tree-type linker with three types of orthogonally cleavable part

Toru Amaya, Hiroshi Tanaka, Takashi Takahashi

Synlett, 503-507, 2004
Effective sialylation method using N-Troc and N-Fmoc β-phenyl thiosialosides and an application to the one-pot two-step synthesis of 2,6-STF Antigen

Masaatsu Adachi, Hiroshi Tanaka, Takashi Takahashi

Synlett, 609-614, 2004

Books and Other Publications

ラボオートメーション技術を活用したタキソールおよび9員環エンジイン化合物の合成

シーエムシー出版, 2009
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer, 2008
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer, 2008
タキソール

アイピーシー, 2007
ロボット・マイクロ合成最前線有機合成の新戦略「合成ロボットを使った天然物合成」

化学同人, 2004

Presentations

100

固相合成法を利用したヒメグルシン類の合成研究

日本化学会第90春季年会, 2010
炭素－炭素結合形成反応を用いたα－イミノカルボキサミド類縁体群の合成

日本化学会第90春季年会, 2010
光照射によりビラジカル発生が誘起される環状エンジイン化合物の合成

日本化学会第90春季年会, 2010
ラジカル環化反応を利用したピリピロペンAの合成研究

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム）, 2010
マイクロリアクターを活用した光熱異性化反応による高効率的なビタミンD3の合成

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム）, 2010

Professional Memberships

Research Projects

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