高橋孝志

タカハシタカシ (Takashi Takahashi)

基本情報

所属: 学習院大学理学部化学科

学位: Ph.D.(コロンビア大学)

J-GLOBAL ID: 200901066027301826
researchmap会員ID: 1000279064

外部リンク: http://www.apc.titech.ac.jp/~ttakahas/

研究分野

ナノテク・材料 / 有機合成化学 /

経歴

もっとみる

学歴

- 1976年

コロンビア大学大学院化学研究科有機合成化学
- 1970年

東北大学理学部化学科

委員歴

受賞

1984年

有機合成化学協会奨励賞

MISC

272

Construction of the ABC Ring System of Taxanes via Stereoselective One-Pot Three-Component Coupling and Intramolecular Alkylation of a Protected Cyanohydrin Ether

Takayuki Serizawa, Shigeru Miyamoto, Shinichiro Fuse, Takayuki Doi, Takashi Takahashi

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 83(8) 942-949 2010年8月
Developmental stage-dependent expression of an alpha 2,8-trisialic acid unit on glycoproteins in mouse brain

Emi Inoko, Yuji Nishiura, Hiroshi Tanaka, Takashi Takahashi, Koichi Furukawa, Ken Kitajima, Chihiro Sato

GLYCOBIOLOGY 20(7) 916-928 2010年7月
Design, synthesis and evaluation and QSAR analysis of (－)-N 1-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors

Jun Takahashi, Ichiro Hijikuro, Takeshi Kihara, Modachur G. Murugesh, Shinichiro Fuse, Yoshinori Tsumura, Akinori Akaike, Tetsuhiro Niidome, Takashi Takahashi, Hachiro Sugimoto

Bioorganic and Medicinal Chemistry Letters 20(5) 1718-1720 2010年3月
Design, synthesis and evaluation of carbamate-modified (－)-N 1-phenetylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors

Jun Takahashi, Ichiro Hijikuro, Takeshi Kihara, Modachur G. Murugesh, Shinichiro Fuse, Yoshinori Tsumura, Akinori Akaike, Tetsuhiro Niidome, Takashi Takahashi, Hachiro Sugimoto

Bioorganic and Medicinal Chemistry Letters 20(5) 1721-1723 2010年3月
Design, synthesis, evaluation and QSAR analysis of N-1-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors

Jun Takahashi, Ichiro Hijikuro, Takeshi Kihara, Modachur G. Murugesh, Shinichiro Fuse, Ryo Kunimoto, Yoshinori Tsumura, Akinori Akaike, Tetsuhiro Niidome, Yasushi Okuno, Takashi Takahashi, Hachiro Sugimoto

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20(5) 1718-1720 2010年3月
Design, synthesis and evaluation of carbamate-modified (-)-N-1-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors

Jun Takahashi, Ichiro Hijikuro, Takeshi Kihara, Modachur G. Murugesh, Shinichiro Fuse, Yoshinori Tsumura, Akinori Akaike, Tetsuhiro Niidome, Takashi Takahashi, Hachiro Sugimoto

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20(5) 1721-1723 2010年3月
Development and Application of a Solution-Phase Automated Synthesizer,

Kazuhiro Machida, Yoichiro Hirose, Shinichiro Fuse, Tohru Sugawara, Takashi Takahashi

Chemical & Pharmaceutical Bulletin 58(1) 87-93 2010年
Development and Application of a Solution-Phase Automated Synthesizer,

Kazuhiro Machida, Yoichiro Hirose, Shinichiro Fuse, Tohru Sugawara, Takashi Takahashi

Chemical & Pharmaceutical Bulletin 58(1) 87-93 2010年
Combinatorial Synthesis of Deoxyhexasaccharides Related to the Landomycin A Sugar Moiety, Based on an Orthogonal Deprotection Strategy

Hiroshi Tanaka, Sho Yamaguchi, Atsushi Yoshizawa, Motoki Takagi, Kazuo Shin-ya, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL 5(6) 1407-1424 2010年
Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity

Hiroshi Tanaka, Yoshikazu Tanaka, Masafumi Minoshima, Sho Yamaguchi, Shinichiro Fuse, Takayuki Doi, Susumu Kawauchi, Hiroshi Sugiyama, Takashi Takahashi

CHEMICAL COMMUNICATIONS 46(32) 5942-5944 2010年
An Efficient Synthesis of a Cyclic Ether Key Intermediate for 9-Membered Masked Enediyne Using an Automated Synthesizer

Yoshikazu Tanaka, Shinichiro Fuse, Hiroshi Tanaka, Takayuki Doi, Takashi Takahashi

ORGANIC PROCESS RESEARCH & DEVELOPMENT 13(6) 1111-1121 2009年11月
Stereoselective one-pot three-component coupling approach towards the synthesis of the AC ring system of taxanes

Takayuki Serizawa, Shigeru Miyamoto, Yoshitaka Numajiri, Shinichiro Fuse, Takayuki Doi, Takashi Takahashi

TETRAHEDRON LETTERS 50(26) 3408-3410 2009年7月
Stereoselective Synthesis of α(2,9) Di- to Tetra-sialic Acids Using a 5,4-N,O-Carbonyl Protected Thiosialoside

Hiroshi Tanaka, Yuji Nishiura, Takashi Takahashi

J. Org. Chem. 74(11) 4383-4386 2009年6月
Stereoselective Synthesis of alpha(2,9) Di- to Tetrasialic Acids, Using a 5,4-N,O-Carbonyl Protected Thiosialoside

Hiroshi Tanaka, Yuji Nishiura, Takashi Takahashi

JOURNAL OF ORGANIC CHEMISTRY 74(11) 4383-4386 2009年6月
A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A

Yusuke Iijima, Asami Munakata, Kazuo Shin-ya, A. Ganesan, Takayuki Doi, Takashi Takahashi

Tetrahedron Letters 50(24) 3408-3410 2009年
Total Synthesis of (-)-Apratoxin A, 34-Epimer, and Its Oxazoline Analogue

Yoshitaka Numajiri, Takashi Takahashi, Takayuki Doi

Chemistry-An Asian Journal 4(1) 111-125 2009年
Efficient Synthesis of the Deoxysugar Part of Versipelostatin by Direct and Stereoselective Glycosylation and Revision of the Structure of the Trisaccharide Unit

Hiroshi Tanaka, Atsushi Yoshizawa, Shuhei Chijiwa, Jun-ya Ueda, Motoki Takagi, Kazuo Shin-ya, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL 4(7) 1114-1125 2009年
Solid-phase combinatorial synthesis of ester-type banana-shaped molecules by sequential palladium-catalyzed carbonylation

Masahito Yoshida, Takayuki Doi, Sungmin Kang, Junji Watanabe, Takashi Takahashi

CHEMICAL COMMUNICATIONS (19) 2756-2758 2009年
A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A

Yusuke Iijima, Asami Munakata, Kazuo Shin-ya, A. Ganesan, Takayuki Doi, Takashi Takahashi

Tetrahedron Letters 50(24) 3408-3410 2009年
An efficient convergent synthesis of GP1c ganglioside epitope

Hiroshi Tanaka, Yuji Nishiura, Takashi Takahashi

Journal of the American Chemical Society 130(51) 17244-17245 2008年12月24日
Efficient Synthesis of an α(2,9) Trisialic Acid by One-Pot Glycosylation and Polymer-Assisted Deprotection

Hiroshi Tanaka, Yusuke Tateno, Yuji Nishiura, Takashi Takahashi

Org. Lett. 10(24) 5597-5600 2008年12月
Efficient Synthesis of an alpha(2,9) Trisialic Acid by One-Pot Glycosylation and Polymer-Assisted Deprotection

Hiroshi Tanaka, Yusuke Tateno, Yuji Nishiura, Takashi Takahashi

ORGANIC LETTERS 10(24) 5597-5600 2008年12月
The Synthesis of Carbohydrate Microarrays by S-Alkylation of the Glass-supported 2-Bromoacetamides

Daisuke Takahashi, Hiroshi Tanaka, Emiko Nakane, Takashi Takahashi

CHEMISTRY LETTERS 37(12) 1252-1253 2008年12月
An Efficient Convergent Synthesis of GP1c Ganglioside Epitope

Hiroshi Tanaka, Yuji Nishiura, Takashi Takahashi

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130(51) 17244-+ 2008年12月
Superconducting gap and pseudogap in iron-based layered superconductor La(O1-xFx)FeAs

Takafumi Sato, Seigo Souma, Kosuke Nakayama, Kensei Terashima, Katsuaki Sugawara, Takashi Takahashi, Yoichi Kamihara, Masahiro Hirano, Hideo Hosono

Journal of the Physical Society of Japan 77(6) 063708 2008年6月
Superconducting gap and pseudogap in iron-based layered superconductor La(O1-xFx)FeAs

Takafumi Sato, Seigo Souma, Kosuke Nakayama, Kensei Terashima, Katsuaki Sugawara, Takashi Takahashi, Yoichi Kamihara, Masahiro Hirano, Hideo Hosono

JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN 77(6) 063708 2008年6月
A synthesis of RGD model cyclic peptide by palladium-catalyzed carbonylative macrolactamization

Takayuki Doi, Seiji Kamioka, Sayaka Shimazu, Takashi Takahashi

ORGANIC LETTERS 10(5) 817-819 2008年3月
Sequential palladium-catalyzed coupling reactions on solid-phase

Takayuki Doi, Hitoshi Inoue, Masatoshi Tokita, Junji Watanabe, Takashi Takahashi

Journal of Combinatorial Chemistry 10(1) 135-141 2008年1月
Sequential palladium-catalyzed coupling reactions on solid-phase

Takayuki Doi, Hitoshi Inoue, Masatoshi Tokita, Junji Watanabe, Takashi Takahashi

JOURNAL OF COMBINATORIAL CHEMISTRY 10(1) 135-141 2008年1月
The Synthesis of D-Trihydroxyllysine-Based Oligopeptides as a Hydrophilic Scaffold and its Application to the Synthesis of Bifunctional Chelating Agents for Use as Bone Tracers

Hiroshi Tanaka, Yoshio Ando, Tsutomu Abe, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL 3(12) 2033-2045 2008年
Synthesis of the octahydroindole unit of aeruginosins via asymmetric hydrogenation of the Diels-Alder adducts of 2-amido-2,4-pentadienoate

Yoichiro Hoshina, Takayuki Doi, Takashi Takahashi

TETRAHEDRON 63(51) 12740-12746 2007年12月
Synthesis of dimethyl gloiosiphone a by way of palladium-catalyzed domino cyclization

Takayuki Doi, Yusuke Iijima, Masaru Takasaki, Takashi Takahashi

JOURNAL OF ORGANIC CHEMISTRY 72(10) 3667-3671 2007年5月
Direct and Stereoselective Synthesis of β-Linked 2,6-Deoxyoligosaccharides

Hiroshi Tanaka, Atsushi Yoshizawa, Takashi Takahashi

Angew. Chem., Int. Ed. 46(14) 2505-2507 2007年
Synthesis of Biologically Active Fluorescence-Labeled Aerugonosin Derivatives

Yoichiro Hoshina, Yoshifumi Yamada, Hiroshi Tanaka, Takayuki Doi, Takashi Takahash

Bioorg. Med. Chem. Lett. 17 2904-2907 2007年
A Divergent Route to 3-Amino-2,3,6-trideoxysugars Including Branched Sugar: Synthesis of Vancosamine, Daunosamine, Saccharosamine, and Ristosamine

Takayuki Doi, Kazuaki Shibata, Atsushi Kinbara, Takashi Takahashi

Chem. Lett. 36(11) 1372-1373 2007年
Synthesis of 3-O-Acylated Epicatechin Derivatives via Sequential One-Pot Multi-Step Reactions

Makoto Kitade, Hiroshi Tanaka, Takashi Takahashi

Heterocycles 73 183-185 2007年
Direct and stereoselective synthesis of beta-linked 2,6-deoxyoligosaccharides

Hiroshi Tanaka, Atsushi Yoshizawa, Takashi Takahashi

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 46(14) 2505-2507 2007年
Solid-phase synthesis of epigallocatechin gallate derivatives

Hiroshi Tanaka, Haruko Miyoshi, Yu-Cheng Chuang, Yoshio Ando, Takashi Takahashi

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 46(31) 5934-5937 2007年
Synthesis of Biologically Active Fluorescence-Labeled Aerugonosin Derivatives

Yoichiro Hoshina, Yoshifumi Yamada, Hiroshi Tanaka, Takayuki Doi, Takashi Takahash

Bioorg. Med. Chem. Lett. 17 2904-2907 2007年
Donor-bound glycosylation for various glycosyl acceptors: Bidirectional solid-phase semisynthesis of vancomycin and its derivatives

Takayuki Doi, Atsushi Kinbara, Hitoshi Inoue, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL 2(1) 188-198 2007年
A Divergent Route to 3-Amino-2,3,6-trideoxysugars Including Branched Sugar: Synthesis of Vancosamine, Daunosamine, Saccharosamine, and Ristosamine

Takayuki Doi, Kazuaki Shibata, Atsushi Kinbara, Takashi Takahashi

Chem. Lett. 36(11) 1372-1373 2007年
Synthesis of 3-O-Acylated Epicatechin Derivatives via Sequential One-Pot Multi-Step Reactions

Makoto Kitade, Hiroshi Tanaka, Takashi Takahashi

Heterocycles 73 183-185 2007年
Polymer-Assisted Solution-phase Synthesis and their Neurite Outgrowth-Promoting Activity of 15-Deoxy-Δ12,14-PGJ2 Derivatives

Hiroshi Tanaka, Tsuyoshi Hasegawa, Hiroko Nakahara, Narumi Kita, Takahiro Shibata, Sho Oe, Makoto Ojika, Koji Uchida, Takashi Takahashi

Chem. Asian J. 1(5) 669-677 2006年11月
Polymer-Assisted Solution-phase Synthesis and their Neurite Outgrowth-Promoting Activity of 15-Deoxy-Δ12,14-PGJ2 Derivatives

Hiroshi Tanaka, Tsuyoshi Hasegawa, Hiroko Nakahara, Narumi Kita, Takahiro Shibata, Sho Oe, Makoto Ojika, Koji Uchida, Takashi Takahashi

Chemistry-An Asian Journal 1(5) 669-677 2006年11月
Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-Delta(12,14)-PGJ(2) derivatives

Hiroshi Tanaka, Tsuyoshi Hasegawa, Narumi Kita, Hiroko Nakahara, Takahiro Shibata, Sho Oe, Makoto Ojika, Koji Uchida, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL 1(5) 669-677 2006年11月
A new mechanism of methotrexate action revealed by target screening with affinity beads

Hitoshi Uga, Chikanori Kuramori, Akiko Ohta, Yasunori Tsuboi, Hiroshi Tanaka, Mamoru Hatakeyama, Yuki Yamaguchi, Takashi Takahashi, Masahiro Kizaki, Hiroshi Handa

MOLECULAR PHARMACOLOGY 70(5) 1832-1839 2006年11月
Efficient Synthesis of (±)-Epigallocatechin Gallate by Reductive Intramolecular Etherification

Makoto Kitade, Yoshiaki Ohno, Hiroshi Tanaka, Takashi Takahashi

Synlett (17) 2827-2829 2006年10月
An efficient synthesis of (+/-)-epigallocatechin gallate by reductive intramolecular etherification

Makoto Kitade, Yoshiaki Ohno, Hiroshi Tanaka, Takashi Takahashi

SYNLETT (17) 2827-2829 2006年10月
Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers

Taichi Ohshiro, Ichiji Namatame, Kenichiro Nagai, Takafumi Sekiguchi, Takayuki Doi, Takashi Takahashi, Kazuaki Akasaka, Lawrence L. Rudel, Hiroshi Tomoda, Satoshi Omura

JOURNAL OF ORGANIC CHEMISTRY 71(20) 7643-7649 2006年9月
A formal total synthesis of taxol aided by an automated synthesizer

Takayuki Doi, Shinichiro Fuse, Shigeru Miyamoto, Kazuoki Nakai, Daisuke Sasuga, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL 1(3) 370-383 2006年9月

書籍等出版物

ラボオートメーション技術を活用したタキソールおよび9員環エンジイン化合物の合成

シーエムシー出版 2009年
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer 2008年
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer 2008年
タキソール

アイピーシー 2007年
ロボット・マイクロ合成最前線有機合成の新戦略「合成ロボットを使った天然物合成」

化学同人 2004年

もっとみる

講演・口頭発表等

100

固相合成法を利用したヒメグルシン類の合成研究

日本化学会第90春季年会 2010年
炭素－炭素結合形成反応を用いたα－イミノカルボキサミド類縁体群の合成

日本化学会第90春季年会 2010年
光照射によりビラジカル発生が誘起される環状エンジイン化合物の合成

日本化学会第90春季年会 2010年
ラジカル環化反応を利用したピリピロペンAの合成研究

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム） 2010年
マイクロリアクターを活用した光熱異性化反応による高効率的なビタミンD3の合成

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム） 2010年

もっとみる

所属学協会

もっとみる

共同研究・競争的資金等の研究課題

もっとみる

一覧へ戻る

高橋 孝志

基本情報

研究分野

経歴

学歴

委員歴

受賞

MISC

書籍等出版物

講演・口頭発表等

所属学協会

共同研究・競争的資金等の研究課題

高橋孝志