Takashi Takahashi

(高橋孝志)

Profile Information

Affiliation: Faculty of Science, Department of Chemistry, Gakushuin University

Degree: Doctor of Philosophy

J-GLOBAL ID: 200901066027301826
researchmap Member ID: 1000279064

External link: http://www.apc.titech.ac.jp/~ttakahas/

Research Areas

Nanotechnology/Materials / Synthetic organic chemistry /

Research History

Education

- 1976

Columbia University
- 1970

Department of Chemistry, Faculty of Science, Tohoku University

Committee Memberships

Awards

1984

有機合成化学協会奨励賞

Misc.

272

Construction of the ABC Ring System of Taxanes via Stereoselective One-Pot Three-Component Coupling and Intramolecular Alkylation of a Protected Cyanohydrin Ether

Takayuki Serizawa, Shigeru Miyamoto, Shinichiro Fuse, Takayuki Doi, Takashi Takahashi

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 83(8) 942-949, Aug, 2010
Developmental stage-dependent expression of an alpha 2,8-trisialic acid unit on glycoproteins in mouse brain

Emi Inoko, Yuji Nishiura, Hiroshi Tanaka, Takashi Takahashi, Koichi Furukawa, Ken Kitajima, Chihiro Sato

GLYCOBIOLOGY, 20(7) 916-928, Jul, 2010
Design, synthesis, evaluation and QSAR analysis of N-1-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors

Jun Takahashi, Ichiro Hijikuro, Takeshi Kihara, Modachur G. Murugesh, Shinichiro Fuse, Ryo Kunimoto, Yoshinori Tsumura, Akinori Akaike, Tetsuhiro Niidome, Yasushi Okuno, Takashi Takahashi, Hachiro Sugimoto

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(5) 1718-1720, Mar, 2010
Design, synthesis and evaluation of carbamate-modified (-)-N-1-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors

Jun Takahashi, Ichiro Hijikuro, Takeshi Kihara, Modachur G. Murugesh, Shinichiro Fuse, Yoshinori Tsumura, Akinori Akaike, Tetsuhiro Niidome, Takashi Takahashi, Hachiro Sugimoto

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(5) 1721-1723, Mar, 2010
Design, synthesis, evaluation and QSAR analysis of N-1-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors

Jun Takahashi, Ichiro Hijikuro, Takeshi Kihara, Modachur G. Murugesh, Shinichiro Fuse, Ryo Kunimoto, Yoshinori Tsumura, Akinori Akaike, Tetsuhiro Niidome, Yasushi Okuno, Takashi Takahashi, Hachiro Sugimoto

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(5) 1718-1720, Mar, 2010
Design, synthesis and evaluation of carbamate-modified (-)-N-1-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors

Jun Takahashi, Ichiro Hijikuro, Takeshi Kihara, Modachur G. Murugesh, Shinichiro Fuse, Yoshinori Tsumura, Akinori Akaike, Tetsuhiro Niidome, Takashi Takahashi, Hachiro Sugimoto

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(5) 1721-1723, Mar, 2010
Development and Application of a Solution-Phase Automated Synthesizer,

Kazuhiro Machida, Yoichiro Hirose, Shinichiro Fuse, Tohru Sugawara, Takashi Takahashi

Chemical & Pharmaceutical Bulletin, 58(1) 87-93, 2010
Development and Application of a Solution-Phase Automated Synthesizer,

Kazuhiro Machida, Yoichiro Hirose, Shinichiro Fuse, Tohru Sugawara, Takashi Takahashi

Chemical & Pharmaceutical Bulletin, 58(1) 87-93, 2010
Combinatorial Synthesis of Deoxyhexasaccharides Related to the Landomycin A Sugar Moiety, Based on an Orthogonal Deprotection Strategy

Hiroshi Tanaka, Sho Yamaguchi, Atsushi Yoshizawa, Motoki Takagi, Kazuo Shin-ya, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL, 5(6) 1407-1424, 2010
Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity

Hiroshi Tanaka, Yoshikazu Tanaka, Masafumi Minoshima, Sho Yamaguchi, Shinichiro Fuse, Takayuki Doi, Susumu Kawauchi, Hiroshi Sugiyama, Takashi Takahashi

CHEMICAL COMMUNICATIONS, 46(32) 5942-5944, 2010
An Efficient Synthesis of a Cyclic Ether Key Intermediate for 9-Membered Masked Enediyne Using an Automated Synthesizer

Yoshikazu Tanaka, Shinichiro Fuse, Hiroshi Tanaka, Takayuki Doi, Takashi Takahashi

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 13(6) 1111-1121, Nov, 2009
Stereoselective one-pot three-component coupling approach towards the synthesis of the AC ring system of taxanes

Takayuki Serizawa, Shigeru Miyamoto, Yoshitaka Numajiri, Shinichiro Fuse, Takayuki Doi, Takashi Takahashi

TETRAHEDRON LETTERS, 50(26) 3408-3410, Jul, 2009
Stereoselective Synthesis of alpha(2,9) Di- to Tetrasialic Acids, Using a 5,4-N,O-Carbonyl Protected Thiosialoside

Hiroshi Tanaka, Yuji Nishiura, Takashi Takahashi

JOURNAL OF ORGANIC CHEMISTRY, 74(11) 4383-4386, Jun, 2009
Stereoselective Synthesis of alpha(2,9) Di- to Tetrasialic Acids, Using a 5,4-N,O-Carbonyl Protected Thiosialoside

Hiroshi Tanaka, Yuji Nishiura, Takashi Takahashi

JOURNAL OF ORGANIC CHEMISTRY, 74(11) 4383-4386, Jun, 2009
A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A

Yusuke Iijima, Asami Munakata, Kazuo Shin-ya, A. Ganesan, Takayuki Doi, Takashi Takahashi

Tetrahedron Letters, 50(24) 3408-3410, 2009
Total Synthesis of (-)-Apratoxin A, 34-Epimer, and Its Oxazoline Analogue

Yoshitaka Numajiri, Takashi Takahashi, Takayuki Doi

Chemistry-An Asian Journal, 4(1) 111-125, 2009
Efficient Synthesis of the Deoxysugar Part of Versipelostatin by Direct and Stereoselective Glycosylation and Revision of the Structure of the Trisaccharide Unit

Hiroshi Tanaka, Atsushi Yoshizawa, Shuhei Chijiwa, Jun-ya Ueda, Motoki Takagi, Kazuo Shin-ya, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL, 4(7) 1114-1125, 2009
Solid-phase combinatorial synthesis of ester-type banana-shaped molecules by sequential palladium-catalyzed carbonylation

Masahito Yoshida, Takayuki Doi, Sungmin Kang, Junji Watanabe, Takashi Takahashi

CHEMICAL COMMUNICATIONS, (19) 2756-2758, 2009
A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A

Yusuke Iijima, Asami Munakata, Kazuo Shin-ya, A. Ganesan, Takayuki Doi, Takashi Takahashi

Tetrahedron Letters, 50(24) 3408-3410, 2009
An efficient convergent synthesis of GP1c ganglioside epitope

Hiroshi Tanaka, Yuji Nishiura, Takashi Takahashi

Journal of the American Chemical Society, 130(51) 17244-17245, Dec 24, 2008
Efficient Synthesis of an alpha(2,9) Trisialic Acid by One-Pot Glycosylation and Polymer-Assisted Deprotection

Hiroshi Tanaka, Yusuke Tateno, Yuji Nishiura, Takashi Takahashi

ORGANIC LETTERS, 10(24) 5597-5600, Dec, 2008
Efficient Synthesis of an alpha(2,9) Trisialic Acid by One-Pot Glycosylation and Polymer-Assisted Deprotection

Hiroshi Tanaka, Yusuke Tateno, Yuji Nishiura, Takashi Takahashi

ORGANIC LETTERS, 10(24) 5597-5600, Dec, 2008
The Synthesis of Carbohydrate Microarrays by S-Alkylation of the Glass-supported 2-Bromoacetamides

Daisuke Takahashi, Hiroshi Tanaka, Emiko Nakane, Takashi Takahashi

CHEMISTRY LETTERS, 37(12) 1252-1253, Dec, 2008
An Efficient Convergent Synthesis of GP1c Ganglioside Epitope

Hiroshi Tanaka, Yuji Nishiura, Takashi Takahashi

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(51) 17244-+, Dec, 2008
Superconducting gap and pseudogap in iron-based layered superconductor La(O1-xFx)FeAs

Takafumi Sato, Seigo Souma, Kosuke Nakayama, Kensei Terashima, Katsuaki Sugawara, Takashi Takahashi, Yoichi Kamihara, Masahiro Hirano, Hideo Hosono

Journal of the Physical Society of Japan, 77(6) 063708, Jun, 2008
Superconducting gap and pseudogap in iron-based layered superconductor La(O1-xFx)FeAs

Takafumi Sato, Seigo Souma, Kosuke Nakayama, Kensei Terashima, Katsuaki Sugawara, Takashi Takahashi, Yoichi Kamihara, Masahiro Hirano, Hideo Hosono

JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 77(6) 063708, Jun, 2008
A synthesis of RGD model cyclic peptide by palladium-catalyzed carbonylative macrolactamization

Takayuki Doi, Seiji Kamioka, Sayaka Shimazu, Takashi Takahashi

ORGANIC LETTERS, 10(5) 817-819, Mar, 2008
Sequential palladium-catalyzed coupling reactions on solid-phase

Takayuki Doi, Hitoshi Inoue, Masatoshi Tokita, Junji Watanabe, Takashi Takahashi

Journal of Combinatorial Chemistry, 10(1) 135-141, Jan, 2008
Sequential palladium-catalyzed coupling reactions on solid-phase

Takayuki Doi, Hitoshi Inoue, Masatoshi Tokita, Junji Watanabe, Takashi Takahashi

JOURNAL OF COMBINATORIAL CHEMISTRY, 10(1) 135-141, Jan, 2008
The Synthesis of D-Trihydroxyllysine-Based Oligopeptides as a Hydrophilic Scaffold and its Application to the Synthesis of Bifunctional Chelating Agents for Use as Bone Tracers

Hiroshi Tanaka, Yoshio Ando, Tsutomu Abe, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL, 3(12) 2033-2045, 2008
Synthesis of the octahydroindole unit of aeruginosins via asymmetric hydrogenation of the Diels-Alder adducts of 2-amido-2,4-pentadienoate

Yoichiro Hoshina, Takayuki Doi, Takashi Takahashi

TETRAHEDRON, 63(51) 12740-12746, Dec, 2007
Synthesis of dimethyl gloiosiphone a by way of palladium-catalyzed domino cyclization

Takayuki Doi, Yusuke Iijima, Masaru Takasaki, Takashi Takahashi

JOURNAL OF ORGANIC CHEMISTRY, 72(10) 3667-3671, May, 2007
Direct and stereoselective synthesis of beta-linked 2,6-deoxyoligosaccharides

Hiroshi Tanaka, Atsushi Yoshizawa, Takashi Takahashi

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(14) 2505-2507, 2007
Synthesis of Biologically Active Fluorescence-Labeled Aerugonosin Derivatives

Yoichiro Hoshina, Yoshifumi Yamada, Hiroshi Tanaka, Takayuki Doi, Takashi Takahash

Bioorg. Med. Chem. Lett., 17 2904-2907, 2007
A Divergent Route to 3-Amino-2,3,6-trideoxysugars Including Branched Sugar: Synthesis of Vancosamine, Daunosamine, Saccharosamine, and Ristosamine

Takayuki Doi, Kazuaki Shibata, Atsushi Kinbara, Takashi Takahashi

Chem. Lett., 36(11) 1372-1373, 2007
Synthesis of 3-O-Acylated Epicatechin Derivatives via Sequential One-Pot Multi-Step Reactions

Makoto Kitade, Hiroshi Tanaka, Takashi Takahashi

Heterocycles, 73 183-185, 2007
Direct and stereoselective synthesis of beta-linked 2,6-deoxyoligosaccharides

Hiroshi Tanaka, Atsushi Yoshizawa, Takashi Takahashi

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(14) 2505-2507, 2007
Solid-phase synthesis of epigallocatechin gallate derivatives

Hiroshi Tanaka, Haruko Miyoshi, Yu-Cheng Chuang, Yoshio Ando, Takashi Takahashi

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(31) 5934-5937, 2007
Synthesis of Biologically Active Fluorescence-Labeled Aerugonosin Derivatives

Yoichiro Hoshina, Yoshifumi Yamada, Hiroshi Tanaka, Takayuki Doi, Takashi Takahash

Bioorg. Med. Chem. Lett., 17 2904-2907, 2007
Donor-bound glycosylation for various glycosyl acceptors: Bidirectional solid-phase semisynthesis of vancomycin and its derivatives

Takayuki Doi, Atsushi Kinbara, Hitoshi Inoue, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL, 2(1) 188-198, 2007
A Divergent Route to 3-Amino-2,3,6-trideoxysugars Including Branched Sugar: Synthesis of Vancosamine, Daunosamine, Saccharosamine, and Ristosamine

Takayuki Doi, Kazuaki Shibata, Atsushi Kinbara, Takashi Takahashi

Chem. Lett., 36(11) 1372-1373, 2007
Synthesis of 3-O-Acylated Epicatechin Derivatives via Sequential One-Pot Multi-Step Reactions

Makoto Kitade, Hiroshi Tanaka, Takashi Takahashi

Heterocycles, 73 183-185, 2007
Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-Delta(12,14)-PGJ(2) derivatives

Hiroshi Tanaka, Tsuyoshi Hasegawa, Narumi Kita, Hiroko Nakahara, Takahiro Shibata, Sho Oe, Makoto Ojika, Koji Uchida, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL, 1(5) 669-677, Nov, 2006
Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-Delta(12,14)-PGJ(2) derivatives

Hiroshi Tanaka, Tsuyoshi Hasegawa, Narumi Kita, Hiroko Nakahara, Takahiro Shibata, Sho Oe, Makoto Ojika, Koji Uchida, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL, 1(5) 669-677, Nov, 2006
Polymer-assisted solution-phase synthesis and neurite-outgrowth-promoting activity of 15-deoxy-Delta(12,14)-PGJ(2) derivatives

Hiroshi Tanaka, Tsuyoshi Hasegawa, Narumi Kita, Hiroko Nakahara, Takahiro Shibata, Sho Oe, Makoto Ojika, Koji Uchida, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL, 1(5) 669-677, Nov, 2006
A new mechanism of methotrexate action revealed by target screening with affinity beads

Hitoshi Uga, Chikanori Kuramori, Akiko Ohta, Yasunori Tsuboi, Hiroshi Tanaka, Mamoru Hatakeyama, Yuki Yamaguchi, Takashi Takahashi, Masahiro Kizaki, Hiroshi Handa

MOLECULAR PHARMACOLOGY, 70(5) 1832-1839, Nov, 2006
An efficient synthesis of (+/-)-epigallocatechin gallate by reductive intramolecular etherification

Makoto Kitade, Yoshiaki Ohno, Hiroshi Tanaka, Takashi Takahashi

SYNLETT, (17) 2827-2829, Oct, 2006
An efficient synthesis of (+/-)-epigallocatechin gallate by reductive intramolecular etherification

Makoto Kitade, Yoshiaki Ohno, Hiroshi Tanaka, Takashi Takahashi

SYNLETT, (17) 2827-2829, Oct, 2006
Absolute stereochemistry of fungal beauveriolide III and ACAT inhibitory activity of four stereoisomers

Taichi Ohshiro, Ichiji Namatame, Kenichiro Nagai, Takafumi Sekiguchi, Takayuki Doi, Takashi Takahashi, Kazuaki Akasaka, Lawrence L. Rudel, Hiroshi Tomoda, Satoshi Omura

JOURNAL OF ORGANIC CHEMISTRY, 71(20) 7643-7649, Sep, 2006
A formal total synthesis of taxol aided by an automated synthesizer

Takayuki Doi, Shinichiro Fuse, Shigeru Miyamoto, Kazuoki Nakai, Daisuke Sasuga, Takashi Takahashi

CHEMISTRY-AN ASIAN JOURNAL, 1(3) 370-383, Sep, 2006

Books and Other Publications

ラボオートメーション技術を活用したタキソールおよび9員環エンジイン化合物の合成

シーエムシー出版, 2009
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer, 2008
Oligosaccharide Synthesis based on Combinatorial Chemsitry and Labo Automation

Springer, 2008
タキソール

アイピーシー, 2007
ロボット・マイクロ合成最前線有機合成の新戦略「合成ロボットを使った天然物合成」

化学同人, 2004

Presentations

100

固相合成法を利用したヒメグルシン類の合成研究

日本化学会第90春季年会, 2010
炭素－炭素結合形成反応を用いたα－イミノカルボキサミド類縁体群の合成

日本化学会第90春季年会, 2010
光照射によりビラジカル発生が誘起される環状エンジイン化合物の合成

日本化学会第90春季年会, 2010
ラジカル環化反応を利用したピリピロペンAの合成研究

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム）, 2010
マイクロリアクターを活用した光熱異性化反応による高効率的なビタミンD3の合成

第５９回有機合成化学協会関東支部シンポジウム（東京農工大シンポジウム）, 2010

Professional Memberships

Research Projects

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