研究者検索結果一覧 小島 修一 小島 修一コジマ シユウイチ (Shuichi Kojima) ダウンロードする帳票の形式を下記より選択して下さい 「教育研究等環境」形式 「文科省帳票様式第4号 ①履歴書」形式 「文科省帳票様式第4号 ②教育研究業績書」形式 基本情報 所属学習院大学 理学部 生命科学科 理学部 生命科学科 教授学位理学士(千葉大学)理学修士(千葉大学)工学博士(東京大学)J-GLOBAL ID200901087624745392researchmap会員ID1000068615 研究キーワード 2 蛋白質 Protein 研究分野 3 ナノテク・材料 / 生体化学 / ライフサイエンス / 分子生物学 / ライフサイエンス / 構造生物化学 / 経歴 6 1991年 - 2007年 :学習院大学理学部助教授 1991年 - 2007年 :Associate Professor, Faculty of Science, Gakushuin University 2007年 -:学習院大学理学部教授 2007年 -:Professor, Faculty of Science, Gakushuin University 1989年 - 1991年 :東京大学工学部助手 もっとみる 学歴 6 - 1989年 東京大学 工学系研究科 工業化学専攻 - 1989年 東京大学 - 1986年 千葉大学 理学研究科 化学専攻 - 1986年 千葉大学 - 1984年 千葉大学 理学部 化学科 もっとみる MISC 100 pH resopnsiveness of fibrous assemblies of repeat-sequence amphipathic α-helix polypeptides Toshiaki Takei, Kouhei Tsumoto, Atsuhiko Okonogi, Akiko Kimura, Shuichi Kojima, Kazumori Yazaki, Tsunetomo Takei, Takuya Ueda, Kin-ichiro Miura Protein Science 24(5) 883-894 2015年5月 Role of positions e and g in the fibrous assembly formation of an amphipathic α-helix-forming polypeptide Toshiaki Takei, Kouhei Tsumoto, Masakuni Yoshino, Shuichi Kojima, Kazumori Yazaki, Takuya Ueda, Tsunetomo Takei, Fumio Arisaka, Kin-ichiro Miura Biopolymers (Peptide Science) 102(3) 260-272 2014年5月 Single Mutation Alters the Substrate Specificity of L-Amino Acid Ligase Takeo Tsuda, Mana Asami, Yoshiaki Koguchi, Shuichi Kojima BIOCHEMISTRY 53(16) 2650-2660 2014年4月 Effects of chain length of an amphipathic polypeptide carrying the repeated amino acid sequence (LETLAKA)n on α-helix and fibrous assembly formation Toshiaki Takei, Kazuya Hasegawa, Katsumi Imada, Keiichi Namba, Kouhei Tsumoto, Yukino Kuriki, Masakuni Yoshino, Kazumori Yazaki, Shuichi Kojima, Tsunetomo Takei, Takuya Ueda, Kin-ichiro Biochemistry 52(16) 2810-2820 2013年4月 Crystallization and preliminary X-ray diffraction analysis of Bacillus subtilis YwfE, an l-amino-acid ligase Takeo Tsuda, Tomomi Suzuki, Shuichi Kojima ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 68(2) 203-206 2012年2月 Increasing the hydrolysis constant of the reactive site upon introduction of an engineered Cys(14)-Cys(39) bond into the ovomucoid third domain from silver pheasant Hikaru Hemmi, Takashi Kumazaki, Shuichi Kojima, Takuya Yoshida, Tadayasu Ohkubo, Hideyoshi Yokosawa, Kin-ichiro Miura, Yuji Kobayashi JOURNAL OF PEPTIDE SCIENCE 17(8) 595-600 2011年8月 Structure analysis of the flavoredoxin from Desulfovibrio vulgaris Miyazaki F reveals key residues that discriminate the functions and properties of the flavin reductase family Naoki Shibata, Yasufumi Ueda, Daisuke Takeuchi, Yoshihiro Haruyama, Shuichi Kojima, Junichi Sato, Youichi Niimura, Masaya Kitamura, Yoshiki Higuchi FEBS JOURNAL 276(17) 4840-4853 2009年9月 Requirement of Ala residues at g positions in heptad sequence of α-helix-forming peptides for formation of fibrous structure 小島 修一, Gaku Aoki, Toyo K. Yamada, Mayu Arii, Shuichi Kojima, Tadashi Mizoguchi The Journal of Biochemistry 144(1) 15-19 2008年7月 Requirement of Ala residues at g position in heptad sequence of alpha-helix-forming peptide for formation of fibrous structure Gaku Aoki, Toyo K. Yamada, Mayu Arii, Shuichi Kojima, Tadashi Mizoguchi JOURNAL OF BIOCHEMISTRY 144(1) 15-19 2008年7月 Effects of hydrophobic amino acid substitution in Pleurotus ostreatus proteinase A inhibitor 1 on its structure and functions as protease inhibitor and intramolecular chaperone Shuichi Kojima, Akane Iwahara, Yuri Hisano, Hideyuki Yanai PROTEIN ENGINEERING DESIGN & SELECTION 20(5) 211-217 2007年5月 The effects of the side chains of hydrophobic aliphatic amino acid residues in an amphipathic polypeptide on the formation of α helix and its assocation 小島 修一, Toshiaki Takei, Atsuhito Okonogi, Kumiko Tateno, Akiko Kimura, Shuichi Kojima, Kazumori Yazaki. Kin-ichiro Miura The Journal of Biochemistry 139(2) 271-278 2006年2月 The effects of the side chains of hydrophobic aliphatic amino acid residues in an amphipathic polypeptide on the formation of a helix and its association T Takei, A Okonogi, K Tateno, A Kimura, S Kojima, K Yazaki, K Miura JOURNAL OF BIOCHEMISTRY 139(2) 271-278 2006年2月 The structure of the third intracellular loop of the muscarinic acetylcholine receptor M-2 subtype S Ichlyama, Y Oka, K Haga, S Kojima, Y Tateishi, M Shirakawa, T Haga FEBS LETTERS 580(1) 23-26 2006年1月 Inhibitor-assisted refolding of protease: A protease inhibitor as an intramolecular chaperone S Kojima, A Iwahara, H Yanai FEBS LETTERS 579(20) 4430-4436 2005年8月 Stabilization of the fibrous structure of an α-helix-forming peptide by sequence reversal 小島 修一, Shuichi Kojima, Yukino Kuriki, Kazumori Yazaki, Kin-ichiro Miura Biochemical and Biophysical Research Communications 331(2) 577-582 2005年6月 Stabilization of the fibrous structure of an alpha-helix-forming peptide by sequence reversal S Kojima, Y Kuriki, K Yazaki, K Miura BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 331(2) 577-582 2005年6月 Mapping the position of the transition stare in the folding of a small α/β protein, POIA1 小島 修一, Shuhei Tanaka, Shuichi Kojima, Atsuo Tamura Chemical Physics 307(2-3) 233-242 2004年12月 Mapping the position of the transition state in the folding of a small alpha/beta protein, POIA1 S Tanaka, S Kojima, A Tamura CHEMICAL PHYSICS 307(2-3) 233-242 2004年12月 Low pH facilitates uptake of proteins by cells through a non-endocytic pathway M Motizuki, T Takei, K Tasaka, S Yokota, S Kojima, T Haga, K Tsurugi JOURNAL OF BIOCHEMISTRY 135(6) 713-719 2004年6月 Cloning and expression of the enolase gene from Desulfovibrio vulgaris (Miyazaki F) M Kitamura, Y Takayama, S Kojima, K Kohno, H Ogata, Y Higuchi, H Inoue BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1676(2) 172-181 2004年1月 Inhibitory specificity change of the ovomucoid third domain of the silver pheasant upon introduction of an engineered Cys(14)-Cys(39) bond H Hemmi, T Kumazaki, T Yamazaki, S Kojima, T Yoshida, Y Kyogoku, M Katsu, F Shinohara, H Yokosawa, K Miura, Y Kobayashi BIOCHEMISTRY 42(9) 2524-2534 2003年3月 Functional tolerance of Streptomyces subtilisin inhibitor toward conformational and stability changes caused by single-point mutations in the hydrophobic core M Oda, A Tamura, K Kanaori, S Kojima, K Miura, K Momma, B Tonomura, K Akasaka JOURNAL OF BIOCHEMISTRY 132(6) 991-995 2002年12月 Structure-activity analysis of an antimicrobial peptide derived from bovine apolipoprotein A-Ⅱ 小島 修一, Mitsuyoshi Motizuki, Takanori Satoh, Toshiaki Takei, Takehito Itoh, Sadaki Yokota, Shuichi Kojima, Kin-ichiro Miura, Tatsuya Samejima, Kunio Tsurugi The Journal of Biochemistry 132(1) 115-119 2002年7月 Structure-activity analysis of an antimicrobial peptide derived from bovine apolipoprotein A-II M Motizuki, T Satoh, T Takei, T Itoh, S Yokota, S Kojima, K Miura, T Samejima, K Tsurugi JOURNAL OF BIOCHEMISTRY 132(1) 115-119 2002年7月 Requirement for hydrophobic Phe residues in Pleurotus ostreatus proteinase A inhibitor 1 for stable inhibition S Kojima, Y Hisano PROTEIN ENGINEERING 15(4) 325-329 2002年4月 Structure of POIA1, a homologous protein to the propeptide of subtilisin: Implication for protein foldability and the function as an intramolecular chaperone H Sasakawa, S Yoshinaga, S Kojima, A Tamura JOURNAL OF MOLECULAR BIOLOGY 317(1) 159-167 2002年3月 Accelerated refolding of subtilisin BPN ' by tertiary-structure-forming mutants of its propeptide S Kojima, H Yanai, K Miura JOURNAL OF BIOCHEMISTRY 130(4) 471-474 2001年10月 Cloning and expression of the catalase gene from the anaerobic bacterium Desulfovibrio vulgaris (Miyazaki F) M Kitamura, T Nakanishi, S Kojima, Kumagai, I, H Inoue JOURNAL OF BIOCHEMISTRY 129(3) 357-364 2001年3月 Alteration of inhibitory properties of Pleurotus ostreatus proteinase A inhibitor 1 by mutation of its C-terminal region S Kojima, Y Hisano, K Miura BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 281(5) 1271-1276 2001年3月 Analysis of the isoform of Xenopus euakryotic translation initiation factor 4E M Wakiyama, A Suzuki, M Saigoh, N Sakai, H Miyoshi, S Kojima, K Miura BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 65(1) 232-235 2001年1月 Effects of amino acid replacements around the reactive site of chicken ovomucoid domain 3 on the inhibitory activity toward chymotrypsin and trypsin S Kojima, N Takagi, T Minagawa, N Fushimi, K Miura PROTEIN ENGINEERING 12(10) 857-862 1999年10月 Expression of a zinc-binding domain of boar spermatidal transition protein 2 in Escherichia coli H Sato, K Akama, S Kojima, K Miura, A Sekine, M Nakano PROTEIN EXPRESSION AND PURIFICATION 16(3) 454-462 1999年8月 Involvement of the C-terminal region of yeast proteinase B inhibitor 2 in its inhibitory action S Kojima, M Deguchi, K Miura JOURNAL OF MOLECULAR BIOLOGY 286(3) 775-785 1999年2月 High performance in refolding of Streptomyces griseus trypsin by the aid of a mutant of Streptomyces subtilisin inhibitor designed as trypsin inhibitor D Nohara, H Sugiura, H Sakakibara, M Matsubara, S Kojima, K Miura, T Sakai JOURNAL OF BIOCHEMISTRY 125(2) 343-347 1999年2月 P1-specificity of aqualysin I (a subtilisin-type serine protease) from Thermus aquaticus YT-1, using P1-substituted derivatives of Streptomyces subtilisin inhibitor T Tanaka, H Matsuzawa, S Kojima, Kumagai, I, K Miura, T Ohta BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 62(10) 2035-2038 1998年10月 An endogenous target protease, SAM-P26, of Streptomyces protease inhibitor (SSI): Primary structure, enzymatic characterization, and its interaction with SSI S Taguchi, S Yamada, S Kojima, H Momose JOURNAL OF BIOCHEMISTRY 124(4) 804-810 1998年10月 Primary structure of Streptomyces griseus metalloendopeptidase II S Kojima, T Kumazaki, S Ishii, K Miura BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 62(7) 1392-1398 1998年7月 Cloning and expression of the gene encoding flavodoxin from Desulfovibrio vulgaris (Miyazaki F) M Kitamura, T Sagara, M Taniguchi, M Ashida, K Ezoe, K Kohno, S Kojima, K Ozawa, H Akutsu, Kumagai, I, T Nakaya JOURNAL OF BIOCHEMISTRY 123(5) 891-898 1998年5月 Tertiary structure formation in the propeptide of subtilisin BPN ' by successive amino acid replacements and its close relation to function S Kojima, T Minagawa, K Miura JOURNAL OF MOLECULAR BIOLOGY 277(5) 1007-1013 1998年4月 The propeptide of subtilisin BPN' as a temporary inhibitor and effect of an amino acid replacement on its inhibitory activity S Kojima, T Minagawa, K Miura FEBS LETTERS 411(1) 128-132 1997年7月 Disulfide bond formation is not involved in cap-binding activity of Xenopus translation initiation factor eIF-4E Motoaki Wakiyama, Nobuya Sakai, Shuichi Kojima, Kin-Ichiro Miura FEBS Letters 409(3) 407-410 1997年6月16日 Disulfide bond formation is not involved in cap-binding activity of Xenopus translation initiation factor eIF-4E M Wakiyama, N Sakai, S Kojima, K Miura FEBS LETTERS 409(3) 407-410 1997年6月 Molecular phylogenetic characterization of Streptomyces protease inhibitor family S Taguchi, S Kojima, M Terabe, Y Kumazawa, H Kohriyama, M Suzuki, K Miura, H Momose JOURNAL OF MOLECULAR EVOLUTION 44(5) 542-551 1997年5月 Cloning and expression of the rubredoxin gene from Desulfovibrio vulgaris (Miyazaki F) - Comparison of the primary structure of desulfoferrodoxin M Kitamura, Y Koshino, Y Kamikawa, K Kohno, S Kojima, K Miura, T Sagara, H Akutsu, Kumagai, I, T Nakaya BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1351(1-2) 239-247 1997年3月 Fibril formation by an amphipathic α-helix-forming polypeptide produced by gene engineering 小島 修一, Shuichi Kojima, Yukino Kuriki, Takao Yoshida, Kazumori Yazaki, Kin-ichiro Miura Proceedings of the Japan Academy 73(1) 7-11 1997年1月 A novel member of the subtilisin-like protease family from Streptomyces albogriseolus M Suzuki, S Taguchi, S Yamada, S Kojima, KI Miura, H Momose JOURNAL OF BACTERIOLOGY 179(2) 430-438 1997年1月 Fibril formation by an amphipathic alpha-helix-forming polypeptide produced by gene engineering S Kojima, Y Kuriki, T Yoshida, K Yazaki, K Miura PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 73(1) 7-11 1997年1月 Synthesis of a squash-type protease inhibitor by gene engineering and effects of replacements of conserved hydrophobic amino acid residues on its inhibitory activity S Kojima, K Miyoshi, K Miura PROTEIN ENGINEERING 9(12) 1241-1246 1996年12月 Synthesis of α-helix-forming peptides by gene engineering methods and their characterization by circular dichroism spectra measurements 小島 修一, Shuichi Kojima, Yukino Kuriki, Yoshihiro Sato, Fumio Arisaka, Izumi Kumagai, Sho Takahashi, Kin-ichiro Miura Biochimica et Biophysica Acta 1294(2) 129-137 1996年5月 Synthesis of alpha-helix-forming peptides by gene engineering methods and their characterization by circular dichroism spectra measurements S Kojima, Y Kuriki, Y Sato, F Arisaka, Kumagai, I, S Takahashi, K Miura BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1294(2) 129-137 1996年5月 12» 書籍等出版物 22 廣川タンパク質化学 第7巻 制御タンパク質‐インヒビター 36ズブチリシンインヒビター‐(共著) 廣川書店 2002年 プロペチドおよびプロテアーゼによるプロテアーゼのフォールディング 蛋白質・核酸・酵素 2001年 プロテアーゼのプロペプチドの二面性:インヒビターおよび分子シャペロン バイオサイエンスとインダストリー 1998年 シリーズ分子生物学6 構造生物学 4.6 プロテアーゼとインヒビター 朝倉書店 1998年 バイオテクノロジー教科書シリーズ9 蛋白質工学概論 (共著) 株式会社 コロナ社 1995年 もっとみる 講演・口頭発表等 16 L-アミノ酸連結酵素YwfEの基質認識様式 第85回日本生化学会大会 2012年 L-アミノ酸連結酵素の結晶構造解析 第11回日本蛋白質科学会年会 2011年 抗生物質バチライシン生合成酵素の結晶構造解析 第84回日本生化学会大会 2011年 銅イオンポンプのドメイン間相互作用 第82回日本生化学会大会 2009年 分子内シャペロンとしてのPOIA1 第7回日本蛋白質科学会年会 2007年 もっとみる 所属学協会 4 日本化学会 日本分子生物学会 日本蛋白質科学会 日本生化学会 共同研究・競争的資金等の研究課題 7 抗生物質の生合成に関わる酵素の構造と機能に関する研究 2009年 Relationship of the protease inhibitor and molecular chaperon activities in the propeptides Grant-in-Aid for Scientific Research 1996年 プロペプチドおよびプロテアーゼインヒビターによる蛋白質の立体構造形成補助作用に関する研究 科学研究費補助金 1996年 Synthesis and Characterization of α-Helix-forming Peptide Grant-in-Aid for Scientific Research 1989年 αヘリックス形成ペプチドによる集合体形成の分子機構に関する研究 科学研究費補助金 1989年 もっとみる
小島 修一コジマ シユウイチ (Shuichi Kojima) ダウンロードする帳票の形式を下記より選択して下さい 「教育研究等環境」形式 「文科省帳票様式第4号 ①履歴書」形式 「文科省帳票様式第4号 ②教育研究業績書」形式 基本情報 所属学習院大学 理学部 生命科学科 理学部 生命科学科 教授学位理学士(千葉大学)理学修士(千葉大学)工学博士(東京大学)J-GLOBAL ID200901087624745392researchmap会員ID1000068615 研究キーワード 2 蛋白質 Protein 研究分野 3 ナノテク・材料 / 生体化学 / ライフサイエンス / 分子生物学 / ライフサイエンス / 構造生物化学 / 経歴 6 1991年 - 2007年 :学習院大学理学部助教授 1991年 - 2007年 :Associate Professor, Faculty of Science, Gakushuin University 2007年 -:学習院大学理学部教授 2007年 -:Professor, Faculty of Science, Gakushuin University 1989年 - 1991年 :東京大学工学部助手 もっとみる 学歴 6 - 1989年 東京大学 工学系研究科 工業化学専攻 - 1989年 東京大学 - 1986年 千葉大学 理学研究科 化学専攻 - 1986年 千葉大学 - 1984年 千葉大学 理学部 化学科 もっとみる MISC 100 pH resopnsiveness of fibrous assemblies of repeat-sequence amphipathic α-helix polypeptides Toshiaki Takei, Kouhei Tsumoto, Atsuhiko Okonogi, Akiko Kimura, Shuichi Kojima, Kazumori Yazaki, Tsunetomo Takei, Takuya Ueda, Kin-ichiro Miura Protein Science 24(5) 883-894 2015年5月 Role of positions e and g in the fibrous assembly formation of an amphipathic α-helix-forming polypeptide Toshiaki Takei, Kouhei Tsumoto, Masakuni Yoshino, Shuichi Kojima, Kazumori Yazaki, Takuya Ueda, Tsunetomo Takei, Fumio Arisaka, Kin-ichiro Miura Biopolymers (Peptide Science) 102(3) 260-272 2014年5月 Single Mutation Alters the Substrate Specificity of L-Amino Acid Ligase Takeo Tsuda, Mana Asami, Yoshiaki Koguchi, Shuichi Kojima BIOCHEMISTRY 53(16) 2650-2660 2014年4月 Effects of chain length of an amphipathic polypeptide carrying the repeated amino acid sequence (LETLAKA)n on α-helix and fibrous assembly formation Toshiaki Takei, Kazuya Hasegawa, Katsumi Imada, Keiichi Namba, Kouhei Tsumoto, Yukino Kuriki, Masakuni Yoshino, Kazumori Yazaki, Shuichi Kojima, Tsunetomo Takei, Takuya Ueda, Kin-ichiro Biochemistry 52(16) 2810-2820 2013年4月 Crystallization and preliminary X-ray diffraction analysis of Bacillus subtilis YwfE, an l-amino-acid ligase Takeo Tsuda, Tomomi Suzuki, Shuichi Kojima ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 68(2) 203-206 2012年2月 Increasing the hydrolysis constant of the reactive site upon introduction of an engineered Cys(14)-Cys(39) bond into the ovomucoid third domain from silver pheasant Hikaru Hemmi, Takashi Kumazaki, Shuichi Kojima, Takuya Yoshida, Tadayasu Ohkubo, Hideyoshi Yokosawa, Kin-ichiro Miura, Yuji Kobayashi JOURNAL OF PEPTIDE SCIENCE 17(8) 595-600 2011年8月 Structure analysis of the flavoredoxin from Desulfovibrio vulgaris Miyazaki F reveals key residues that discriminate the functions and properties of the flavin reductase family Naoki Shibata, Yasufumi Ueda, Daisuke Takeuchi, Yoshihiro Haruyama, Shuichi Kojima, Junichi Sato, Youichi Niimura, Masaya Kitamura, Yoshiki Higuchi FEBS JOURNAL 276(17) 4840-4853 2009年9月 Requirement of Ala residues at g positions in heptad sequence of α-helix-forming peptides for formation of fibrous structure 小島 修一, Gaku Aoki, Toyo K. Yamada, Mayu Arii, Shuichi Kojima, Tadashi Mizoguchi The Journal of Biochemistry 144(1) 15-19 2008年7月 Requirement of Ala residues at g position in heptad sequence of alpha-helix-forming peptide for formation of fibrous structure Gaku Aoki, Toyo K. Yamada, Mayu Arii, Shuichi Kojima, Tadashi Mizoguchi JOURNAL OF BIOCHEMISTRY 144(1) 15-19 2008年7月 Effects of hydrophobic amino acid substitution in Pleurotus ostreatus proteinase A inhibitor 1 on its structure and functions as protease inhibitor and intramolecular chaperone Shuichi Kojima, Akane Iwahara, Yuri Hisano, Hideyuki Yanai PROTEIN ENGINEERING DESIGN & SELECTION 20(5) 211-217 2007年5月 The effects of the side chains of hydrophobic aliphatic amino acid residues in an amphipathic polypeptide on the formation of α helix and its assocation 小島 修一, Toshiaki Takei, Atsuhito Okonogi, Kumiko Tateno, Akiko Kimura, Shuichi Kojima, Kazumori Yazaki. Kin-ichiro Miura The Journal of Biochemistry 139(2) 271-278 2006年2月 The effects of the side chains of hydrophobic aliphatic amino acid residues in an amphipathic polypeptide on the formation of a helix and its association T Takei, A Okonogi, K Tateno, A Kimura, S Kojima, K Yazaki, K Miura JOURNAL OF BIOCHEMISTRY 139(2) 271-278 2006年2月 The structure of the third intracellular loop of the muscarinic acetylcholine receptor M-2 subtype S Ichlyama, Y Oka, K Haga, S Kojima, Y Tateishi, M Shirakawa, T Haga FEBS LETTERS 580(1) 23-26 2006年1月 Inhibitor-assisted refolding of protease: A protease inhibitor as an intramolecular chaperone S Kojima, A Iwahara, H Yanai FEBS LETTERS 579(20) 4430-4436 2005年8月 Stabilization of the fibrous structure of an α-helix-forming peptide by sequence reversal 小島 修一, Shuichi Kojima, Yukino Kuriki, Kazumori Yazaki, Kin-ichiro Miura Biochemical and Biophysical Research Communications 331(2) 577-582 2005年6月 Stabilization of the fibrous structure of an alpha-helix-forming peptide by sequence reversal S Kojima, Y Kuriki, K Yazaki, K Miura BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 331(2) 577-582 2005年6月 Mapping the position of the transition stare in the folding of a small α/β protein, POIA1 小島 修一, Shuhei Tanaka, Shuichi Kojima, Atsuo Tamura Chemical Physics 307(2-3) 233-242 2004年12月 Mapping the position of the transition state in the folding of a small alpha/beta protein, POIA1 S Tanaka, S Kojima, A Tamura CHEMICAL PHYSICS 307(2-3) 233-242 2004年12月 Low pH facilitates uptake of proteins by cells through a non-endocytic pathway M Motizuki, T Takei, K Tasaka, S Yokota, S Kojima, T Haga, K Tsurugi JOURNAL OF BIOCHEMISTRY 135(6) 713-719 2004年6月 Cloning and expression of the enolase gene from Desulfovibrio vulgaris (Miyazaki F) M Kitamura, Y Takayama, S Kojima, K Kohno, H Ogata, Y Higuchi, H Inoue BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1676(2) 172-181 2004年1月 Inhibitory specificity change of the ovomucoid third domain of the silver pheasant upon introduction of an engineered Cys(14)-Cys(39) bond H Hemmi, T Kumazaki, T Yamazaki, S Kojima, T Yoshida, Y Kyogoku, M Katsu, F Shinohara, H Yokosawa, K Miura, Y Kobayashi BIOCHEMISTRY 42(9) 2524-2534 2003年3月 Functional tolerance of Streptomyces subtilisin inhibitor toward conformational and stability changes caused by single-point mutations in the hydrophobic core M Oda, A Tamura, K Kanaori, S Kojima, K Miura, K Momma, B Tonomura, K Akasaka JOURNAL OF BIOCHEMISTRY 132(6) 991-995 2002年12月 Structure-activity analysis of an antimicrobial peptide derived from bovine apolipoprotein A-Ⅱ 小島 修一, Mitsuyoshi Motizuki, Takanori Satoh, Toshiaki Takei, Takehito Itoh, Sadaki Yokota, Shuichi Kojima, Kin-ichiro Miura, Tatsuya Samejima, Kunio Tsurugi The Journal of Biochemistry 132(1) 115-119 2002年7月 Structure-activity analysis of an antimicrobial peptide derived from bovine apolipoprotein A-II M Motizuki, T Satoh, T Takei, T Itoh, S Yokota, S Kojima, K Miura, T Samejima, K Tsurugi JOURNAL OF BIOCHEMISTRY 132(1) 115-119 2002年7月 Requirement for hydrophobic Phe residues in Pleurotus ostreatus proteinase A inhibitor 1 for stable inhibition S Kojima, Y Hisano PROTEIN ENGINEERING 15(4) 325-329 2002年4月 Structure of POIA1, a homologous protein to the propeptide of subtilisin: Implication for protein foldability and the function as an intramolecular chaperone H Sasakawa, S Yoshinaga, S Kojima, A Tamura JOURNAL OF MOLECULAR BIOLOGY 317(1) 159-167 2002年3月 Accelerated refolding of subtilisin BPN ' by tertiary-structure-forming mutants of its propeptide S Kojima, H Yanai, K Miura JOURNAL OF BIOCHEMISTRY 130(4) 471-474 2001年10月 Cloning and expression of the catalase gene from the anaerobic bacterium Desulfovibrio vulgaris (Miyazaki F) M Kitamura, T Nakanishi, S Kojima, Kumagai, I, H Inoue JOURNAL OF BIOCHEMISTRY 129(3) 357-364 2001年3月 Alteration of inhibitory properties of Pleurotus ostreatus proteinase A inhibitor 1 by mutation of its C-terminal region S Kojima, Y Hisano, K Miura BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 281(5) 1271-1276 2001年3月 Analysis of the isoform of Xenopus euakryotic translation initiation factor 4E M Wakiyama, A Suzuki, M Saigoh, N Sakai, H Miyoshi, S Kojima, K Miura BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 65(1) 232-235 2001年1月 Effects of amino acid replacements around the reactive site of chicken ovomucoid domain 3 on the inhibitory activity toward chymotrypsin and trypsin S Kojima, N Takagi, T Minagawa, N Fushimi, K Miura PROTEIN ENGINEERING 12(10) 857-862 1999年10月 Expression of a zinc-binding domain of boar spermatidal transition protein 2 in Escherichia coli H Sato, K Akama, S Kojima, K Miura, A Sekine, M Nakano PROTEIN EXPRESSION AND PURIFICATION 16(3) 454-462 1999年8月 Involvement of the C-terminal region of yeast proteinase B inhibitor 2 in its inhibitory action S Kojima, M Deguchi, K Miura JOURNAL OF MOLECULAR BIOLOGY 286(3) 775-785 1999年2月 High performance in refolding of Streptomyces griseus trypsin by the aid of a mutant of Streptomyces subtilisin inhibitor designed as trypsin inhibitor D Nohara, H Sugiura, H Sakakibara, M Matsubara, S Kojima, K Miura, T Sakai JOURNAL OF BIOCHEMISTRY 125(2) 343-347 1999年2月 P1-specificity of aqualysin I (a subtilisin-type serine protease) from Thermus aquaticus YT-1, using P1-substituted derivatives of Streptomyces subtilisin inhibitor T Tanaka, H Matsuzawa, S Kojima, Kumagai, I, K Miura, T Ohta BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 62(10) 2035-2038 1998年10月 An endogenous target protease, SAM-P26, of Streptomyces protease inhibitor (SSI): Primary structure, enzymatic characterization, and its interaction with SSI S Taguchi, S Yamada, S Kojima, H Momose JOURNAL OF BIOCHEMISTRY 124(4) 804-810 1998年10月 Primary structure of Streptomyces griseus metalloendopeptidase II S Kojima, T Kumazaki, S Ishii, K Miura BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 62(7) 1392-1398 1998年7月 Cloning and expression of the gene encoding flavodoxin from Desulfovibrio vulgaris (Miyazaki F) M Kitamura, T Sagara, M Taniguchi, M Ashida, K Ezoe, K Kohno, S Kojima, K Ozawa, H Akutsu, Kumagai, I, T Nakaya JOURNAL OF BIOCHEMISTRY 123(5) 891-898 1998年5月 Tertiary structure formation in the propeptide of subtilisin BPN ' by successive amino acid replacements and its close relation to function S Kojima, T Minagawa, K Miura JOURNAL OF MOLECULAR BIOLOGY 277(5) 1007-1013 1998年4月 The propeptide of subtilisin BPN' as a temporary inhibitor and effect of an amino acid replacement on its inhibitory activity S Kojima, T Minagawa, K Miura FEBS LETTERS 411(1) 128-132 1997年7月 Disulfide bond formation is not involved in cap-binding activity of Xenopus translation initiation factor eIF-4E Motoaki Wakiyama, Nobuya Sakai, Shuichi Kojima, Kin-Ichiro Miura FEBS Letters 409(3) 407-410 1997年6月16日 Disulfide bond formation is not involved in cap-binding activity of Xenopus translation initiation factor eIF-4E M Wakiyama, N Sakai, S Kojima, K Miura FEBS LETTERS 409(3) 407-410 1997年6月 Molecular phylogenetic characterization of Streptomyces protease inhibitor family S Taguchi, S Kojima, M Terabe, Y Kumazawa, H Kohriyama, M Suzuki, K Miura, H Momose JOURNAL OF MOLECULAR EVOLUTION 44(5) 542-551 1997年5月 Cloning and expression of the rubredoxin gene from Desulfovibrio vulgaris (Miyazaki F) - Comparison of the primary structure of desulfoferrodoxin M Kitamura, Y Koshino, Y Kamikawa, K Kohno, S Kojima, K Miura, T Sagara, H Akutsu, Kumagai, I, T Nakaya BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1351(1-2) 239-247 1997年3月 Fibril formation by an amphipathic α-helix-forming polypeptide produced by gene engineering 小島 修一, Shuichi Kojima, Yukino Kuriki, Takao Yoshida, Kazumori Yazaki, Kin-ichiro Miura Proceedings of the Japan Academy 73(1) 7-11 1997年1月 A novel member of the subtilisin-like protease family from Streptomyces albogriseolus M Suzuki, S Taguchi, S Yamada, S Kojima, KI Miura, H Momose JOURNAL OF BACTERIOLOGY 179(2) 430-438 1997年1月 Fibril formation by an amphipathic alpha-helix-forming polypeptide produced by gene engineering S Kojima, Y Kuriki, T Yoshida, K Yazaki, K Miura PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 73(1) 7-11 1997年1月 Synthesis of a squash-type protease inhibitor by gene engineering and effects of replacements of conserved hydrophobic amino acid residues on its inhibitory activity S Kojima, K Miyoshi, K Miura PROTEIN ENGINEERING 9(12) 1241-1246 1996年12月 Synthesis of α-helix-forming peptides by gene engineering methods and their characterization by circular dichroism spectra measurements 小島 修一, Shuichi Kojima, Yukino Kuriki, Yoshihiro Sato, Fumio Arisaka, Izumi Kumagai, Sho Takahashi, Kin-ichiro Miura Biochimica et Biophysica Acta 1294(2) 129-137 1996年5月 Synthesis of alpha-helix-forming peptides by gene engineering methods and their characterization by circular dichroism spectra measurements S Kojima, Y Kuriki, Y Sato, F Arisaka, Kumagai, I, S Takahashi, K Miura BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1294(2) 129-137 1996年5月 12» 書籍等出版物 22 廣川タンパク質化学 第7巻 制御タンパク質‐インヒビター 36ズブチリシンインヒビター‐(共著) 廣川書店 2002年 プロペチドおよびプロテアーゼによるプロテアーゼのフォールディング 蛋白質・核酸・酵素 2001年 プロテアーゼのプロペプチドの二面性:インヒビターおよび分子シャペロン バイオサイエンスとインダストリー 1998年 シリーズ分子生物学6 構造生物学 4.6 プロテアーゼとインヒビター 朝倉書店 1998年 バイオテクノロジー教科書シリーズ9 蛋白質工学概論 (共著) 株式会社 コロナ社 1995年 もっとみる 講演・口頭発表等 16 L-アミノ酸連結酵素YwfEの基質認識様式 第85回日本生化学会大会 2012年 L-アミノ酸連結酵素の結晶構造解析 第11回日本蛋白質科学会年会 2011年 抗生物質バチライシン生合成酵素の結晶構造解析 第84回日本生化学会大会 2011年 銅イオンポンプのドメイン間相互作用 第82回日本生化学会大会 2009年 分子内シャペロンとしてのPOIA1 第7回日本蛋白質科学会年会 2007年 もっとみる 所属学協会 4 日本化学会 日本分子生物学会 日本蛋白質科学会 日本生化学会 共同研究・競争的資金等の研究課題 7 抗生物質の生合成に関わる酵素の構造と機能に関する研究 2009年 Relationship of the protease inhibitor and molecular chaperon activities in the propeptides Grant-in-Aid for Scientific Research 1996年 プロペプチドおよびプロテアーゼインヒビターによる蛋白質の立体構造形成補助作用に関する研究 科学研究費補助金 1996年 Synthesis and Characterization of α-Helix-forming Peptide Grant-in-Aid for Scientific Research 1989年 αヘリックス形成ペプチドによる集合体形成の分子機構に関する研究 科学研究費補助金 1989年 もっとみる