Faculty of International Social Sciences

Tatsuya Morofuji

  (諸藤 達也)

Profile Information

Affiliation
Faculty of ScienceDepartment of Chemistry, Gakushuin University
Degree
博士(工学)(京都大学)

Researcher number
20824064
J-GLOBAL ID
201801010089828850
researchmap Member ID
B000290957

External link

Research History

 4

Awards

 2

Papers

 9
  • Tatsuya Morofuji, Hanae Kinoshita, Naokazu Kano
    Chemical Communications, 2019  Peer-reviewed
  • Tatsuya Morofuji, Akihiro Shimizu, Jun-ichi Yoshida
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(31) 9816-9819, Aug, 2015  Peer-reviewed
    A new approach for electrooxidative coupling of aromatic compounds and primary alkylamines bearing a functional group such as a hydroxyl group and an amino group was developed. The key to the success of the transformation is heterocydization of functional primary alkylamines. Treatment of primary alkylamines bearing a functional group with nitriles or their equivalents gives the corresponding heterocycles. The electrochemical oxidation of aromatic substrates in the presence of the heterocycles followed by chemical reaction under nonoxidative conditions gave the desired coupling products.
  • Tatsuya Morofuji, Akihiro Shimizu, Jun-ichi Yoshida
    CHEMISTRY-A EUROPEAN JOURNAL, 21(8) 3211-3214, Feb, 2015  Peer-reviewed
    A new method for metal-free intramolecular C-H amination has been developed. Electrochemical oxidation of 2-pyrimidyloxybenzenes and 2-pyrimidylthiobenzenes, which can be easily prepared from phenols and thiophenols, respectively, followed by the treatment of the resulting pyrimidinium ions with piperidine gives 2-aminobenzoxazoles and 2-aminobenzothiazoles, respectively.
  • Toshiki Nokami, Naoki Musya, Tatsuya Morofuji, Keiji Takeda, Masahiro Takumi, Akihiro Shimizu, Jun-ichi Yoshida
    BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 10 3097-3103, Dec, 2014  Peer-reviewed
    Dendronized polystyrene having peripheral bromo groups was prepared from the dendronization of unfunctionalized polystyrene with dendritic diarylcarbenium ions bearing peripheral bromo groups using the "cation pool" method. The palladium-catalyzed amination of the peripheral bromo groups with diarylamine gave dendronized polystyrene equipped with peripheral triarylamines, which exhibited two sets of reversible redox peaks in the cyclic voltammetry curves.
  • Tatsuya Morofuji, Akihiro Shimizu, Jun-ichi Yoshida
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(12) 4496-4499, Mar, 2014  Peer-reviewed
    A method for the C-N coupling of imidazoles based on electrooxidative C-H functionalization of aromatic and benzylic compounds has been developed. The key to the success is the formation of protected imidazolium ions as initial products, avoiding overoxidation. Deprotection under nonoxidative conditions affords N-substituted imidazoles. Various functional groups are compatible with the present transformation. To demonstrate the power of the method, a P450 17 inhibiter and an antifungal agent having N-substituted imidazole structures were synthesized.

Presentations

 2