理学部

秋山 隆彦

アキヤマ タカヒコ  (Takahiko Akiyama)

基本情報

所属
学習院大学 理学部 化学科 教授

J-GLOBAL ID
200901007447424579
researchmap会員ID
1000167339

論文

 46

MISC

 209
  • Keiji Mori, Ryo Isogai, Yuto Kamei, Masahiro Yamanaka, Takahiko Akiyama
    Journal of the American Chemical Society 140(20) 6203-6207 2018年5月23日  
    Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp3)-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp3)-H bond functionalization: (1) a highly enantio- and diastereoselective C(sp3)-H bond functionalization by chiral magnesium bisphosphate (first [1,5]-hydride shift), and (2) a highly diastereoselective C(sp3)-H bond functionalization by an achiral catalyst (Yb(OTf)3, second [1,5]-hydride shift).
  • Masamichi Miyagawa, Kensuke Takashima, Takahiko Akiyama
    Synlett 2018年5月16日  
    Copyright © 2018, Georg Thieme Verlag. All rights reserved. An enantioselective transfer hydrogenation reaction of alkynyl ketimine bearing a trifluoromethyl group was accomplished. Chemoselective reduction of ketimine was achieved by the combined use of chiral phosphoric acid and benzothiazoline to give α-trifluoromethyl propargylamine in good to high yields and with excellent enantioselectivity.
  • Masamichi Miyagawa, Takahiko Akiyama
    Chemistry Letters 47(1) 78-81 2018年  
    The Tishchenko reaction is one of the useful methods for ester synthesis. Intra- and intermolecular Tishchenko reactions using metallic zinc are described. A practical Tishchenko reaction using metallic zinc was applied to various benzaldehydes to give products in good to excellent yields (up to 95%). A sequential reaction with Ullmann coupling afforded lactones in high yields from 2-bromobenzaldehyde derivatives.
  • 秋山 隆彦
    ファインケミカル : 調査・資料・報道・抄録 46(3) 6-11 2017年3月  
  • Keiji Mori, Hiroki Kishi, Takahiko Akiyama
    SYNTHESIS-STUTTGART 49(2) 365-370 2017年1月  
    We report herein a highly efficient kinetic resolution of PHANOL by chiral phosphoric acid catalyzed asymmetric acylation. PHANOL enantiomers were well differentiated by the chiral environment of chiral phosphoric acid, and both the corresponding monoester and PHANOL were obtained with excellent enantioselectivities (98% ee and 92% ee, respectively). Detailed examination of the substrates suggests that the presence of two hydroxy groups in PHANOL was critical for both reactivity and enantioselectivity.

書籍等出版物

 1

共同研究・競争的資金等の研究課題

 27