Curriculum Vitaes

Takahiko Akiyama

  (秋山 隆彦)

Profile Information

Affiliation
Faculty of Science, Department of Chemistry, Gakushuin University

J-GLOBAL ID
200901007447424579
researchmap Member ID
1000167339

Papers

 46

Misc.

 209
  • Keiji Mori, Ryo Isogai, Yuto Kamei, Masahiro Yamanaka, Takahiko Akiyama
    Journal of the American Chemical Society, 140(20) 6203-6207, May 23, 2018  
    Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp3)-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp3)-H bond functionalization: (1) a highly enantio- and diastereoselective C(sp3)-H bond functionalization by chiral magnesium bisphosphate (first [1,5]-hydride shift), and (2) a highly diastereoselective C(sp3)-H bond functionalization by an achiral catalyst (Yb(OTf)3, second [1,5]-hydride shift).
  • Masamichi Miyagawa, Kensuke Takashima, Takahiko Akiyama
    Synlett, May 16, 2018  
    Copyright © 2018, Georg Thieme Verlag. All rights reserved. An enantioselective transfer hydrogenation reaction of alkynyl ketimine bearing a trifluoromethyl group was accomplished. Chemoselective reduction of ketimine was achieved by the combined use of chiral phosphoric acid and benzothiazoline to give α-trifluoromethyl propargylamine in good to high yields and with excellent enantioselectivity.
  • Masamichi Miyagawa, Takahiko Akiyama
    Chemistry Letters, 47(1) 78-81, 2018  
    The Tishchenko reaction is one of the useful methods for ester synthesis. Intra- and intermolecular Tishchenko reactions using metallic zinc are described. A practical Tishchenko reaction using metallic zinc was applied to various benzaldehydes to give products in good to excellent yields (up to 95%). A sequential reaction with Ullmann coupling afforded lactones in high yields from 2-bromobenzaldehyde derivatives.
  • Keiji Mori, Hiroki Kishi, Takahiko Akiyama
    SYNTHESIS-STUTTGART, 49(2) 365-370, Jan, 2017  
    We report herein a highly efficient kinetic resolution of PHANOL by chiral phosphoric acid catalyzed asymmetric acylation. PHANOL enantiomers were well differentiated by the chiral environment of chiral phosphoric acid, and both the corresponding monoester and PHANOL were obtained with excellent enantioselectivities (98% ee and 92% ee, respectively). Detailed examination of the substrates suggests that the presence of two hydroxy groups in PHANOL was critical for both reactivity and enantioselectivity.

Books and Other Publications

 1

Research Projects

 27