Takahiko Akiyama

(秋山隆彦)

Profile Information

Affiliation: Faculty of Science, Department of Chemistry, Gakushuin University

ORCID ID: https://orcid.org/0000-0003-4709-4107
J-GLOBAL ID: 200901007447424579
researchmap Member ID: 1000167339

External link: https://www-cc.gakushuin.ac.jp/~940020/index_E.html

Research Interests

Research Areas

Research History

Apr, 1997 - Present

Professor, Department of Chemistry, Faculty of Science, Gakushuin University
Apr, 1994 - Mar, 1997

Associate Professor, Department of Chemistry, Gakushuin University
Jul, 1988 - Mar, 1994

Assistant Professor, Department of Resources Chemistry, Faculty of Engineering, Ehime University
Apr, 1992 - Mar, 1993

Visiting Scholar, Department of Chemistry, Stanford University
Apr, 1985 - Jun, 1988

Research Chemist, Shionogi Research Laboratories, Shionogi & Co., Ltd.

Education

- 1985

The University of Tokyo
- 1985

Graduate School, Division of Science, The University of Tokyo
- 1980

Department of Chemistry, Faculty of Science, The University of Tokyo
- 1980

Faculty of Science, The University of Tokyo

Committee Memberships

Feb, 2021 - Feb, 2023

会長, 有機合成化学協会
Apr, 2018 - Mar, 2022

学術システム研究センター主任研究員, 独立行政法人日本学術振興会
May, 2018 - May, 2020

理事, 日本化学会

Awards

Feb, 2018

Synthetic Organic Chemistry Award, Japan, The Society of Synthetic Organic Chemistry, Japan

AKIYAMA Takahiko
Aug, 2016

Arthur C. Cope Scholar Award, American Chemical Society

AKIYAMA Takahiko
Mar, 2016

Humboldt Research Award, Humboldt Foundation

AKIYAMA Takahiko
Nov, 2012

Nagoya Silver Medal, Banyu Life Science Foundation International

AKIYAMA Takahiko
Mar, 2009

The Chemical Society of Japan Award for Creative Work for 2009, The Chemical Society of Japan

Papers

Fluoride‐Coupled Electron Transfer and Hydrogen‐Atom‐Transfer‐Mediated Synthesis of Difluoromethylarenes

Tatsuhiro Uchikura, Kaho Ohashi, Fua Akutsu, Takahiko Akiyama

European Journal of Organic Chemistry, Dec 19, 2025
Transfer Hydrogenation of β-Trifluoromethylated Nitroalkenes Catalyzed by Chiral Calcium Phosphate

Tatsuhiro Uchikura, Yuki Kaneko, Takanobu Setogawa, Tatsushi Oishi, Takahiko Akiyama

ACS Organic & Inorganic Au, Aug 6, 2025
Visible-Light-Driven Racemization of 1,1′-Binaphthyl-2,2′-diamine (BINAM) Derivatives

Tatsuhiro Uchikura, Mikoto Sato, Yuki Kanno, Yukino Fukuda, Yurina Hara, Kota Yamamoto, Takahiko Akiyama

Organic Letters, Feb 28, 2025
Electron donor–acceptor (EDA) complex mediated visible-light driven sulfur–fluorine bond reduction of pentafluorosulfanyl arenes using potassium iodide

Tatsuhiro Uchikura, Fua Akutsu, Takahiko Akiyama

Chemical Communications, 2025
Synthesis of indole-fused benzodiazepine derivatives by photocatalyzed cascade reaction

Tatsushi Oishi, Tatsuhiro Uchikura, Takahiko Akiyama

Chemical Communications, 2025

Misc.

203

Synthesis of pyrroles: reaction of chromium N-alkylaminocarbene complexes with alpha,beta-unsaturated aldehydes

Kohei Fuchibe, Daisuke Ono, Takahiko Akiyama

CHEMICAL COMMUNICATIONS, (21) 2271-2273, 2006
Enantioselective three-component synthesis of 4-arylated dehydroprolines: [3+2] annulation of allenylstannane and alpha-imino ester

K Fuchibe, R Hatemata, T Akiyama

TETRAHEDRON LETTERS, 46(49) 8563-8566, Dec, 2005
Bronsted acid-catalyzed addition and cyclization reaction with imine: From aqueous reaction to enantioselective reactions

T Akiyama, K Fuchibe, J Itoh

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 63(11) 1062-1068, Nov, 2005
Bronsted acid-catalyzed addition and cyclization reaction with imine: From aqueous reaction to enantioselective reactions

T Akiyama, K Fuchibe, J Itoh

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 63(11) 1062-1068, Nov, 2005
Montmorillonite K10 catalyzed nucleophilic addition reaction to aldimines in water

T Akiyama, K Matsuda, K Fuchibe

SYNTHESIS-STUTTGART, (15) 2606-2608(15) 2606-2608, Oct, 2005
Enantioselective Mannich-type reaction catalyzed by a chiral bronsted acid derived from TADDOL

T Akiyama, Y Saitoh, H Morita, K Fuchibe

ADVANCED SYNTHESIS & CATALYSIS, 347(11-13) 1523-1526, Oct, 2005
Enantioselective Mannich-type reaction catalyzed by a chiral bronsted acid derived from TADDOL

T Akiyama, Y Saitoh, H Morita, K Fuchibe

ADVANCED SYNTHESIS & CATALYSIS, 347(11-13) 1523-1526, Oct, 2005
Enantioselective Mannich-type reaction catalyzed by a chiral bronsted acid derived from TADDOL

T Akiyama, Y Saitoh, H Morita, K Fuchibe

ADVANCED SYNTHESIS & CATALYSIS, 347(11-13) 1523-1526, Oct, 2005
Chiral Bronsted acid catalyzed enantioselective hydrophosphonylation of imines: Asymmetric synthesis of alpha-amino phosphonates

T Akiyama, H Morita, J Itoh, K Fuchibe

ORGANIC LETTERS, 7(13) 2583-2585, Jun, 2005
Mannich-type reaction promoted by an ionic liquid

T Akiyama, A Suzuki, K Fuchibe

SYNLETT, (6) 1024-1026(6) 1024-1026, Apr, 2005
[3+2] Cycloaddition reactions of cyclopropylmethylsilanes and alpha-keto aldehydes: Trans- and cis-selective formation of 2-silylmethyltetrahydrofurans

K Fuchibe, Y Aoki, T Akiyama

CHEMISTRY LETTERS, 34(4) 538-539, Apr, 2005
Cu(I)-catalyzed enantioselective [3 + 2] cycloaddition reaction of 1-alkylallenylsilane with α-imino ester: Asymmetric synthesis of dehydroproline derivatives

Kazunori Daidouji, Kohei Fuchibe, Takahiko Akiyama

Organic Letters, 7(6) 1051-1053, Mar 17, 2005
Cu(I)-catalyzed enantioselective [3+2] cycloaddition reaction of 1-alkylallenylsilane with alpha-imino ester: Asymmetric synthesis of dehydroproline derivatives

K Daidouji, K Fuchibe, T Akiyama

ORGANIC LETTERS, 7(6) 1051-1053, Mar, 2005
Cu(I)-catalyzed enantioselective [3+2] cycloaddition reaction of 1-alkylallenylsilane with alpha-imino ester: Asymmetric synthesis of dehydroproline derivatives

K Daidouji, K Fuchibe, T Akiyama

ORGANIC LETTERS, 7(6) 1051-1053, Mar, 2005
HCl-catalyzed stereoselective Mannich reaction in H2O-SDS system

T Akiyama, K Matsuda, K Fuchibe

SYNLETT, (2) 322-324(2) 322-324, Feb, 2005
HCl-catalyzed stereoselective Mannich reaction in H2O-SDS system

T Akiyama, K Matsuda, K Fuchibe

SYNLETT, (2) 322-324, Feb, 2005
Brønsted Acid-catalyzed Addition and Cycloaddition Reaction with Imine: From Aqueous Reaction to Enantioselective Reactions

有機合成化学協会誌, 63(11), 1062-1068, 2005
Synthesis of aryl-substituted quinoline derivatives via Bronsted acid-catalyzed [4+2] aza Diels-Alder reaction

T Akiyama, S Nakashima, K Yokota, K Fuchibe

CHEMISTRY LETTERS, 33(7) 922-923, Jul, 2004
Facile method for the preparation of triarylsulfonium bromides using Grignard reagents and chlorotrimethylsilane as an activator

S Imazeki, M Sumino, K Fukasawa, M Ishihara, T Akiyama

SYNTHESIS-STUTTGART, (10) 1648-1654(10) 1648-1654, Jul, 2004
Niobium-catalyzed reduction of monofluoroarenes with LiAlH4

K Fuchibe, T Akiyama

SYNLETT, (7), 1282-1284(7) 1282-1284, Jun, 2004
A novel approach to 2-arylated quinolines: Electrocyclization of alkynyl imines via vinylidene complexes

K Sangu, K Fuchibe, T Akiyama

ORGANIC LETTERS, 6(3) 353-355, Feb, 2004
A novel approach to 2-arylated quinolines: Electrocyclization of alkynyl imines via vinylidene complexes

K Sangu, K Fuchibe, T Akiyama

ORGANIC LETTERS, 6(3) 353-355, Feb, 2004
A Novel Approach to 2-Substituted Quinolines: Electrocyclization of Alkynyl Imines via Vinylidene Complexes

Organic Letters, 6, (3) 353-355, 2004
Enantioselective Mannich-type reaction catalyzed by a chiral Bronsted acid

T Akiyama, J Itoh, K Yokota, K Fuchibe

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 43(12) 1566-1568, 2004
A Novel Approach to 2-Substituted Quinolines: Electrocyclization of Alkynyl Imines via Vinylidene Complexes

Organic Letters, 6, (3) 353-355, 2004
Cu(I)-catalyzed enantioselective [2+2] cycloaddition of 1-methoxyallenylsilane with alpha-imino ester: Chiral synthesis of alpha,beta-unsaturated acylsilanes

T Akiyama, K Daidouji, K Fuchibe

ORGANIC LETTERS, 5(20) 3691-3693, Oct, 2003
Cu(I)-catalyzed enantioselective [2+2] cycloaddition of 1-methoxyallenylsilane with alpha-imino ester: Chiral synthesis of alpha,beta-unsaturated acylsilanes

T Akiyama, K Daidouji, K Fuchibe

ORGANIC LETTERS, 5(20) 3691-3693, Oct, 2003
Bronsted acid-mediated synthesis of alpha-amino phosphonates under solvent-free conditions

T Akiyama, M Sanada, K Fuchibe

SYNLETT, (10, 1463-1464(10) 1463-1464, Aug, 2003
Bronsted acid-mediated synthesis of alpha-amino phosphonates under solvent-free conditions

T Akiyama, M Sanada, K Fuchibe

SYNLETT, (10), 1463-1464(10) 1463-1464, Aug, 2003
Bronsted acid-mediated synthesis of alpha-amino phosphonates under solvent-free conditions

T Akiyama, M Sanada, K Fuchibe

SYNLETT, (10) 1463-1464, Aug, 2003
Stereoselective synthesis of CF3-substituted aziridines by Lewis acid-mediated aziridination of aldimines with diazoacetates

T Akiyama, S Ogi, K Fuchibe

TETRAHEDRON LETTERS, 44(21) 4011-4013, May, 2003
Synthesis of a novel crown ether derived from chiro-inositol and its catalytic activity on the asymmetric Michael addition

T Akiyama, M Hara, K Fuchibe, S Sakamoto, K Yamaguchi

CHEMICAL COMMUNICATIONS, (14), 1734-1735(14) 1734-1735, 2003
Cu(I)-catalyzed Enantioselective [2+2] Cycloaddition of 1-Methoxyallenylsilane with a-Imino Ester: Chiral Synthesis of a,b-Unsaturated Acylsilanes

Org. Lett., 5, (20), 3691 - 3693, 2003
Cu(I)-catalyzed Enantioselective [2+2] Cycloaddition of 1-Methoxyallenylsilane with a-Imino Ester: Chiral Synthesis of a,b-Unsaturated Acylsilanes

Org. Lett., 5, (20), 3691 - 3693, 2003
Novel thermal reaction of Fischer carbene complexes with imines: Synthesis of beta-methoxy allylic amine derivatives

K Sangu, H Kagoshima, K Fuchibe, T Akiyama

ORGANIC LETTERS, 4(22) 3967-3969, Oct, 2002
Mannich-type reaction catalyzed by HBF4 in water: Effect of the loading of surfactant

T Akiyama, J Itoh, K Fuchibe

SYNLETT, 8, 1269(8) 1269-1272, Aug, 2002
Brønsted Acid-Catalyzed Mannich-Type Reactions in Aqueous Media

Takahiko Akiyama, Jim Takaya, Hirotaka Kagoshima

Advanced Synthesis and Catalysis, 344(3-4) 338-347, May, 2002
Reduction of Ketones with Low-Valent Samarium Reagents in the Presence of Chlorosilane

(7) 37-43, Mar 31, 2002
Catalytic, enantioselective propargyl- and allenylation reactions of alpha-imino ester

H Kagoshima, T Uzawa, T Akiyama

CHEMISTRY LETTERS, 3, 298(3) 298-299, Mar, 2002
Catalytic, enantioselective propargyl- and allenylation reactions of alpha-imino ester

H Kagoshima, T Uzawa, T Akiyama

CHEMISTRY LETTERS, 3, 298(3) 298-299, Mar, 2002
Enantioselective Alkylation Reaction of Aldehydes with Et2Zn by Use of Amino Alcohols Derived from Cyclitol as Chiral Source

秋山隆彦, 堀口尚文, 小川昭弥, 福沢信一

中央大学理工学研究所論文集, (8) 59-62, 2002
Novel Thermal Reaction of Fishier Carbene Complex** with Imves: Synthesis of B-Methoxy Amine Derivatibves

Org. Lett, 4(22), 3967, 2002
Bronsted Acic-Catalyged Mannich-type Reactions in Aqueous Media

Adv. Syuth. Cat, 344(3), 338, 2002
Montmorillonite K10-Catalyzed A₂a Diels-Alder Aldimires, Generated in Situ form Aliphatic Aldehyds and Amcou is Aqueous Medic

Synlett, 11, 1898, 2002
Tin(II) chloride mediated allylation of aldimines generated in situ with allylstannane in water

T Akiyama, Y Onuma

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 9, 1157(9) 1157-1158, 2002
Montmorillonite K10-Catalyzed A₂a Diels-Alder Aldimires, Generated in Situ form Aliphatic Aldehyds and Amcou is Aqueous Medic

Synlett, 11, 1898, 2002
Novel Thermal Reaction of Fishier Carbene Complex** with Imves: Synthesis of B-Methoxy Amine Derivatibves

Org. Lett, 4(22), 3967, 2002
Bronsred A*** Catalyged Mannich-type Reactions in Aqueous Media

Adv. Syuth. Cat, 344(3), 338, 2002
Tin(II) chloride mediated allylation of aldimines generated in situ with allylstannane in water

T Akiyama, Y Onuma

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 9, 1157(9) 1157-1158, 2002
The asymmetric [3+2] cycloaddition reaction of chiral alkenyl Fischer carbene complexes with imines: Synthesis of optically pure 2,5-disubstituted-3-pyrrolidinones

H Kagoshima, T Okamura, T Akiyama

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 123(29) 7182-7183, Jul, 2001

Books and Other Publications

Germaniium in Organic Synthesis in "Main Group Metals in Organic Synthesis"

Wiley-VCH, 2004 (ISBN: 3527305084)

Professional Memberships

Research Projects

Development of novel catalytic reactions by combining chiral phosphoric acid and photochemistry

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
New Development of Asymmetric Catalytic Reactions Using Chiral Phosphoric Acid

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
On-demand asymmetric synthesis using the cooperative system of chiral phosphoric acid and photoredox catalyst

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2022
軸性不斉を有するキラルビアリールの回転障壁を下げることは可能か？

科学研究費補助金挑戦的研究（萌芽）, 日本学術振興会, Apr, 2018 - Mar, 2020

秋山隆彦
キラルリン酸およびその誘導体を用いた不斉合成反応の新展開

科学研究費補助金基盤研究（B）, 日本学術振興会, Apr, 2017 - Mar, 2020

秋山隆彦

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