Wenjuan Ma Shah Adil Ishtiyaq Ahmad Michihiro Hashimoto Ahad Khalilnezhad Miho Kataoka Yuichiro Arima Yosuke Tanaka Shigeru Yanagi Terumasa Umemoto Toshio Suda
The EMBO Journal 43(3) 339-361 2024年1月
Abstract
Hematopoietic stem cell (HSC) divisional fate and function are determined by cellular metabolism, yet the contribution of specific cellular organelles and metabolic pathways to blood maintenance and stress-induced responses in the bone m...
Shun Nagashima Naoki Ito Isshin Shiiba Hiroki Shimura Shigeru Yanagi
The Journal of Biochemistry 173(1) 1-11 2022年11月 [査読有り]
Abstract
Mitochondria are involved in various cellular processes, such as energy production, inflammatory responses, and cell death. Mitochondrial dysfunction is associated with many age-related diseases, including neurological disorders and hea...
Abnormal mitochondrial fragmentation by dynamin-related protein1 (Drp1) is associated with the progression of aging-associated heart diseases, including heart failure and myocardial infarction (MI). Here, we report a protective role of outer mitoc...
Most oncolytic virotherapy has thus far employed viruses deficient in genes essential for replication in normal cells but not in cancer cells. Intra-tumoral injection of such viruses has resulted in clinically significant anti-tumor effects on the...
Yasushige Aoyagi Yoshihiro Hayashi Yuka Harada Kwangmin Choi Natsumi Matsunuma Daichi Sadato Yuki Maemoto Akihiro Ito Shigeru Yanagi Daniel T Starczynowski Hironori Harada
Cancer discovery 2021年8月 [査読有り]
Ineffective hematopoiesis is a fundamental process leading to the pathogenesis of myelodysplastic syndromes (MDS). However, the pathobiological mediators of ineffective hematopoiesis in MDS remain unclear. Here, we demonstrated that overwhelming m...
人文科学研究科
理学部