国際センター - 学習院大学研究者情報

研究キーワード

老化 ,脳神経疾患 ,神経科学

研究分野

ライフサイエンス / 神経科学一般 /

学歴

-

1981年3月

九州大学大学院

-

1979年3月

九州大学理学部生物学科

論文

<2 345 6 >

Enhanced Tau Protein Translation by Hyper-Excitation

Shunsuke Kobayashi Toru Tanaka Yoshiyuki Soeda Akihiko Takashima

Frontiers in Aging Neuroscience 11 322-322 2019年11月 [査読有り]

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs

Mari Nakamura Seiji Shiozawa Daisuke Tsuboi Mutsuki Amano Hirotaka Watanabe Sumihiro Maeda Taeko Kimura Sho Yoshimatsu Fumihiko Kisa Celeste M. Karch Tomohiro Miyasaka Akihiko Takashima Naruhiko Sahara Shin-ichi Hisanaga Takeshi Ikeuchi Kozo Kaibuchi Hideyuki Okano

Stem Cell Reports 13(4) 684-699 2019年10月 [査読有り]

Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain.

Atsuko Kubo Shouyou Ueda Ayaka Yamane Satoko Wada-Kakuda Mai Narita Makoto Matsuyama Akane Nomori Akihiko Takashima Taisuke Kato Osamu Onodera Motohito Goto Mamoru Ito Takami Tomiyama Hiroshi Mori Shigeo Murayama Yasuo Ihara Hiroaki Misonou Tomohiro Miyasaka

The Journal of neuroscience : the official journal of the Society for Neuroscience 39(34) 6781-6797 2019年8月 [査読有り]

Tau is a microtubule (MT)-associated protein that is localized to the axon. In Alzheimer's disease, the distribution of tau undergoes a remarkable alteration, leading to the formation of tau inclusions in the somatodendritic compartment. To invest...

Synthesis of (R,S)-isoproterenol, an inhibitor of tau aggregation, as an ¹¹C-labeled PET tracer via reductive alkylation of (R,S)-norepinephrine with [2-¹¹C]acetone

Hiroshi Ikenuma Hiroko Koyama N. Kajino Yasuyuki Kimura Aya Ogata Junichiro Abe Yasuhiro Kawasumi Takashi Kato Akihiko Takashima K. Ito Masaaki Suzuki

Bioorganic and Medicinal Chemistry Letters 29(16) 2107-2111 2019年8月 [査読有り]

© 2019 Elsevier Ltd (R,S)-Isoproterenol inhibits the formation of toxic granular tau oligomers associated with neuronal loss and development of cognitive disorders, and is an attractive drug candidate for Alzheimer's disease. To elucidate its beha...

Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology

Joana Margarida Silva Sara Rodrigues Belém Sampaio-Marques Patrícia Gomes Andreia Neves-Carvalho Chrysoula Dioli Carina Soares-Cunha Brandon F Mazuik Akihiko Takashima Paula Ludovico Benjamin Wolozin Nuno Sousa Ioannis Sotiropoulos

Cell Death & Differentiation 26(8) 1411-1427 2019年8月 [査読有り]