Yuta Takaichi James K Chambers Yasuhisa Ano Akihiko Takashima Hiroyuki Nakayama Kazuyuki Uchida
Journal of Neuropathology & Experimental Neurology 80(8) 731-740 2021年6月 [査読有り]
<title>Abstract</title>
The simultaneous accumulation of multiple pathological proteins, such as hyperphosphorylated tau (hp-tau) and phosphorylated α-synuclein (p-αSyn), has been reported in the brains of patients with various neurodegenerative ...
Taro Saito Tomoki Chiku Mikiko Oka Satoko Wada-Kakuda Mika Nobuhara Toshiya Oba Kanako Shinno Saori Abe Akiko Asada Akio Sumioka Akihiko Takashima Tomohiro Miyasaka Kanae Ando
Human molecular genetics 30(21) 1955-1967 2021年6月 [査読有り]
Accumulation of microtubule-associated tau protein is thought to cause neuron loss in a group of neurodegenerative diseases called tauopathies. In diseased brains, tau molecules adopt pathological structures that propagate into insoluble forms wit...
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) as senile plaques and cerebral amyloid angiopathy, and hyperphosphorylated tau (hp-tau) as neurofibrillary tangles in the brain. The AD-related pathology has been repo...
Riki Koike Yuta Takaichi Yoshiyuki Soeda Akihiko Takashima
Aging brain 1 100022-100022 2021年
Glycogen synthase kinase 3β (GSK-3β) is a therapeutic target for various age-related neurodegenerative diseases. It is linked to the two main pathological features of Alzheimer's disease (AD), tau and amyloid β (Aβ); GSK-3β is a major candidate to...
Yasuhisa Ano Rena Ohya Akihiko Takashima Kazuyuki Uchida Hiroyuki Nakayama
Frontiers in nutrition 8 724134-724134 2021年 [査読有り]
With the rapid increase in aging populations worldwide, there has been an increase in demand for preventive and therapeutic measures for age-related cognitive decline and dementia. Epidemiological studies show that consumption of dairy products re...
人文科学研究科
理学部