BACKGROUND: MAPT is a causative gene in frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), a hereditary degenerative disease with various clinical manifestations, including progressive supranuclear palsy, corticobasal syn...
Riki Koike Yoshiyuki Soeda Atsushi Kasai Yusuke Fujioka Shinsuke Ishigaki Akihiro Yamanaka Yuta Takaichi James K Chambers Kazuyuki Uchida Hirohisa Watanabe Akihiko Takashima
Brain communications 6(1) fcad359 2024年
Alzheimer's disease is a devastating disease that is accompanied by dementia, and its incidence increases with age. However, no interventions have exhibited clear therapeutic effects. We aimed to develop and characterize behavioural tasks that all...
We aimed to develop behavioral tasks that can identify early signs of Alzheimer’s disease (AD) in order to facilitate the development of preventative and therapeutic interventions.
Yasuhisa Ano Yuta Takaichi Rena Ohya Kazuyuki Uchida Hiroyuki Nakayama Akihiko Takashima
Nutritional neuroscience 1-12 2022年7月
Neurodegenerative diseases involving pathological tau protein aggregation are collectively known as tauopathies and include Alzheimer's disease and Pick's disease. Recent studies show that the intake of tryptophan-tyrosine (Trp-Tyr)-related β-lact...
Frontiers in Molecular Neuroscience (APRIL) 2012年4月
In Alzheimer's disease (AD), tau hyperphosphorylation and neurofibrillary tangle (NFT) formation are strongly associated with dementia, a characteristic and early feature of this disease. Glycogen synthase kinase 3β (GSK-3β) is a pivotal kinase in...
Frontiers in Molecular Neuroscience (MARCH) 1-14 2012年3月
In Alzheimer's disease (AD), tau hyperphosphorylation and neurofibrillary tangle (NFT) formation are strongly associated with dementia, a characteristic and early feature of this disease. Glycogen synthase kinase 3β (GSK-3β) is a pivotal kinase in...
人文科学研究科
理学部