Yasuhisa Ano Yuta Takaichi Rena Ohya Kazuyuki Uchida Hiroyuki Nakayama Akihiko Takashima
Nutritional neuroscience 1-12 2022年7月
Neurodegenerative diseases involving pathological tau protein aggregation are collectively known as tauopathies and include Alzheimer's disease and Pick's disease. Recent studies show that the intake of tryptophan-tyrosine (Trp-Tyr)-related β-lact...
Biochimica et biophysica acta. General subjects 1866(7) 130135-130135 2022年7月
BACKGROUND: In Alzheimer's disease (AD), abnormally phosphorylated tau in the somatodendrite compartment of brain neurons causes synaptic loss, resulting in neuron death. Although the mechanism by which hyperphosphorylated tau appears in dendrites...
Fumiko Konishi Tadasu Furusho Yoshiyuki Soeda Jun Yamauchi Shoko Kobayashi Masatoshi Ito Takuma Araki Sarasa Kogure Akihiko Takashima Susumu Takekoshi
Scientific reports 12(1) 996-996 2022年1月
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of extracellular amyloid-beta peptides (Aβ) resulting in senile plaques and intracellular hyperphosphorylated tau protein resulting in neurofibrillary tangl...
Journal of Alzheimer's Disease 37(3) 565-568 2013年
Tauopathies are neurodegenerative diseases characterized behaviorally by dementia and neuropathologically by neurofibrillary tangles and neuronal loss. Tau gene mutations have been found in frontotemporal dementia with parkinsonism linked to chrom...
人文科学研究科