BACKGROUND: MAPT is a causative gene in frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), a hereditary degenerative disease with various clinical manifestations, including progressive supranuclear palsy, corticobasal syn...
Alzheimer's disease is a devastating disease that is accompanied by dementia, and its incidence increases with age. However, no interventions have exhibited clear therapeutic effects. We aimed to develop and characterize behavioural tasks that all...
We aimed to develop behavioral tasks that can identify early signs of Alzheimer’s disease (AD) in order to facilitate the development of preventative and therapeutic interventions.
Neurodegenerative diseases involving pathological tau protein aggregation are collectively known as tauopathies and include Alzheimer's disease and Pick's disease. Recent studies show that the intake of tryptophan-tyrosine (Trp-Tyr)-related β-lact...
小野賢二郎   LI Lei   高村雄策   吉池裕二   池田篤平   西条寿夫   高島明彦   TEPLOW David B   ZAGORSKI Michael G   山田正仁   
山田正仁   小野賢二郎   LI Lei   高村雄策   吉池裕二   池田篤平   西条寿夫   高島明彦   TEPLOW David B.   ZAGORSKI Michael G.   
Journal of Alzheimer's Disease 37(3) 565-568 2013年
Tauopathies are neurodegenerative diseases characterized behaviorally by dementia and neuropathologically by neurofibrillary tangles and neuronal loss. Tau gene mutations have been found in frontotemporal dementia with parkinsonism linked to chrom...