The ESC2 gene encodes a protein with two tandem C-terminal SUMO-like domains and is conserved from yeasts to humans. Previous Studies have implicated Esc2 in gene silencing. Here, we explore the functional significance of SUMO-like domains and des...
Background: DNA double-strand breaks (DSBs) are induced by exogenous insults such as ionizing radiation and chemical exposure, and they can also arise as a consequence of stalled or collapsed DNA replication forks. Failure to repair DSBs can lead ...
JOURNAL OF BIOLOGICAL CHEMISTRY 281(41) 30941-30946 2006年10月 [査読有り]
Protein degradation in bacteria plays a dynamic and critical role in the cellular response to environmental stimuli such as heat shock and DNA damage and in removing damaged proteins or protein aggregates. Escherichia coli recN is a member of the ...
MOLECULAR AND CELLULAR BIOLOGY 26(14) 5509-5517 2006年7月 [査読有り]
Proliferating cell nuclear antigen (PCNA), a sliding clamp required for processive DNA synthesis, provides attachment sites for various other proteins that function in DNA replication. DNA repair. cell cycle progression and chromatin assembly. It ...