菱田卓

研究者氏名	菱田卓
	ヒシダタカシ
URL	https://www.univ.gakushuin.ac.jp/sci/bio/
所属	学習院大学
部署	理学部生命科学科
職名	教授
J-Global ID	200901001733863530

研究キーワード

DNA損傷チェックポイント ,DNA修復 ,DNA相同組み換え ,DNA複製 ,genome stability ,DNA replication ,DNA recombination

研究分野

ライフサイエンス / 分子生物学 /
ライフサイエンス / 遺伝学 /

経歴

2011年4月

現在

学習院大学理学部生命科学科教授

2007年4月

2011年3月

大阪大学微生物病研究所ゲノム動態研究グループ准教授

2005年7月

2007年3月

大阪大学微生物病研究所助教授

2001年4月

2005年6月

大阪大学微生物病研究所助手

2000年4月

2001年3月

日本学術振興会特別研究員（PD）

論文

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Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells

Nami Haruta Yoshino Kubota Takashi Hishida

NUCLEIC ACIDS RESEARCH 40(17) 8406-8415 2012年9月 [査読有り]

UV radiation induces two major types of DNA lesions, cyclobutane pyrimidine dimers (CPDs) and 6-4 pyrimidine-pyrimidine photoproducts, which are both primarily repaired by nucleotide excision repair (NER). Here, we investigated how chronic low-dos...

Srs2 Plays a Critical Role in Reversible G(2) Arrest upon Chronic and Low Doses of UV Irradiation via Two Distinct Homologous Recombination-Dependent Mechanisms in Postreplication Repair-Deficient Cells

Takashi Hishida Yoshihiro Hirade Nami Haruta Yoshino Kubota Hiroshi Iwasaki

MOLECULAR AND CELLULAR BIOLOGY 30(20) 4840-4850 2010年10月 [査読有り]

Differential posttranslational modification of proliferating cell nuclear antigen (PCNA) by ubiquitin or SUMO plays an important role in coordinating the processes of DNA replication and DNA damage tolerance. Previously it was shown that the loss ...

PCNA Mono-Ubiquitination and Activation of Translesion DNA Polymerases by DNA Polymerase alpha

Motoshi Suzuki Atsuko Niimi Siripan Limsirichaikul Shuta Tomida Qin Miao Huang Shunji Izuta Jiro Usukura Yasutomo Itoh Takashi Hishida Tomohiro Akashi Yoshiyuki Nakagawa Akihiko Kikuchi Youri Pavlov Takashi Murate Takashi Takahashi

JOURNAL OF BIOCHEMISTRY 146(1) 13-21 2009年7月 [査読有り]

Translesion DNA synthesis (TLS) involves PCNA mono-ubiquitination and TLS DNA polymerases (pols). Recent evidence has shown that the mono-ubiquitination is induced not only by DNA damage but also by other factors that induce stalling of the DNA re...

[DNA damage tolerance through replication bypass of stalled replication forks].

Hishida T

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54(4 Suppl) 388-393 2009年3月

RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

Takashi Hishida Yoshino Kubota Antony M. Carr Hiroshi Iwasaki

NATURE 457(7229) 612-U124 2009年1月 [査読有り]

In nature, organisms are exposed to chronic low- dose ultraviolet light ( CLUV) as opposed to the acute high doses common to laboratory experiments. Analysis of the cellular response to acute high-dose exposure has delineated the importance of dir...