BIOCHEMICAL SOCIETY TRANSACTIONS 32(5) 738-741 2004年11月
G-protein-coupled receptors constitute the largest transmembrane receptor family in human. They are generally activated on binding their specific ligands at the extracellular side of membranes. The signal carried by an agonist is then transmitted ...
T Okada   M Sugihara   AN Bondar   M Elstner   P Entel   Buss, V   
JOURNAL OF MOLECULAR BIOLOGY 342(2) 571-583 2004年9月
A new high-resolution structure is reported for bovine rhodopsin, the visual pigment in rod photoreceptor cells. Substantial improvement of the resolution limit to 2.2 Angstrom has been achieved by new crystallization conditions, which also reduce...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(9) 5982-5987 2002年4月
Activation of G protein-coupled receptors (GPCRs) is triggered and regulated by structural rearrangement of the transmembrane heptahelical bundle containing a number of highly conserved residues. in rhodopsin, a prototypical GPCR, the helical bund...