椎葉一心

研究者氏名	椎葉一心
	シイバイッシン
URL
所属	学習院大学
部署	理学部生命分子科学研究所
職名
その他の所属	東京薬科大学客員研究員
科研費研究者番号	30884481
ORCID ID	0000-0002-8093-1782
J-Global ID	202001009829771490

研究キーワード

ミトコンドリア ,ユビキチン ,オルガネラコンタクト ,鉄代謝 ,オルガネラバイオロジー ,レドックス ,ユビキチンリガーゼ ,褐色脂肪細胞 ,脂肪酸代謝 ,パーキンソン病

研究分野

ライフサイエンス / 細胞生物学 /
ライフサイエンス / 分子生物学 /

論文

12 >

Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation

Takeshi Tokuyama Hideki Uosaki Ayumu Sugiura Gen Nishitai Keisuke Takeda Shun Nagashima Isshin Shiiba Naoki Ito Taku Amo Satoshi Mohri Akiyuki Nishimura Motohiro Nishida Ayumu Konno Hirokazu Hirai Satoshi Ishido, Takahiro Yoshizawa Takayuki Shindo Shingo Takada Shintaro Kinugawa Ryoko Inatome Shigeru Yanagi

iScience 2022年

MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.

Naoki Ito Takara Takahashi Isshin Shiiba Shun Nagashima Ryoko Inatome Shigeru Yanagi

Journal of biochemistry 2021年12月

The transfer of phospholipids from the endoplasmic reticulum to mitochondria via the mitochondria-endoplasmic reticulum (ER) contact site (MERCS) is essential for maintaining mitochondrial function and integrity. Here, we identified RMDN3/PTPIP51,...

Forebrain-specific deficiency of the GTPase CRAG/Centaurin-γ3 leads to immature dentate gyri and hyperactivity in mice.

Shun Nagashima Naoki Ito Reiki Kobayashi Isshin Shiiba Hiroki Shimura Toshifumi Fukuda Hideo Hagihara Tsuyoshi Miyakawa Ryoko Inatome Shigeru Yanagi

The Journal of biological chemistry 100620-100620 2021年3月

Mouse models of various neuropsychiatric disorders, such as schizophrenia, often display an immature dentate gyrus, characterized by increased numbers of immature neurons and neuronal progenitors and a dearth of mature neurons. We previously demon...

MITOL promotes cell survival by degrading Parkin during mitophagy.

Isshin Shiiba Keisuke Takeda Shun Nagashima Naoki Ito Takeshi Tokuyama Shun-Ichi Yamashita Tomotake Kanki Toru Komatsu Yasuteru Urano Yuuta Fujikawa Ryoko Inatome Shigeru Yanagi

EMBO reports 22(3) e49097 2021年3月

Parkin promotes cell survival by removing damaged mitochondria via mitophagy. However, although some studies have suggested that Parkin induces cell death, the regulatory mechanism underlying the dual role of Parkin remains unknown. Herein, we rep...

Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-β oligomer generation.

Keisuke Takeda Aoi Uda Mikihiro Mitsubori Shun Nagashima Hiroko Iwasaki Naoki Ito Isshin Shiiba Satoshi Ishido Masaaki Matsuoka Ryoko Inatome Shigeru Yanagi

Communications biology 4(1) 192-192 2021年2月

Mitochondrial pathophysiology is implicated in the development of Alzheimer's disease (AD). An integrative database of gene dysregulation suggests that the mitochondrial ubiquitin ligase MITOL/MARCH5, a fine-tuner of mitochondrial dynamics and fun...