椎葉一心

研究者氏名	椎葉一心
	シイバイッシン
URL
所属	学習院大学
部署	理学部生命分子科学研究所
職名	助教
学位	博士 (生命科学)
その他の所属	東京薬科大学客員研究員
科研費研究者番号	30884481
ORCID ID	0000-0002-8093-1782
J-Global ID	202001009829771490

研究キーワード

ミトコンドリア ,ユビキチン ,オルガネラコンタクト ,鉄代謝 ,オルガネラバイオロジー ,レドックス ,ユビキチンリガーゼ ,褐色脂肪細胞 ,脂肪酸代謝 ,パーキンソン病

研究分野

ライフサイエンス / 細胞生物学 /
ライフサイエンス / 分子生物学 /

受賞

2023年10月

公益財団法人日本生化学会, 第31回 JB論文賞

公益財団法人井上科学振興財団, 第40回井上研究奨励賞

論文

12 3 >

Ubiquitin-mediated mitochondrial regulation by MITOL/MARCHF5 at a glance

Shun Nagashima Naoki Ito Isshin Shiiba Hiroki Shimura Shigeru Yanagi

The Journal of Biochemistry 2022年11月

Abstract

Mitochondria are involved in various cellular processes, such as energy production, inflammatory responses, and cell death. Mitochondrial dysfunction is associated with many age-related diseases, including neurological disorders and hea...

Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation

Takeshi Tokuyama Hideki Uosaki Ayumu Sugiura Gen Nishitai Keisuke Takeda Shun Nagashima Isshin Shiiba Naoki Ito Taku Amo Satoshi Mohri Akiyuki Nishimura Motohiro Nishida Ayumu Konno Hirokazu Hirai Satoshi Ishido, Takahiro Yoshizawa Takayuki Shindo Shingo Takada Shintaro Kinugawa Ryoko Inatome Shigeru Yanagi

iScience 25(7) 104582-104582 2022年

Abnormal mitochondrial fragmentation by dynamin-related protein1 (Drp1) is associated with the progression of aging-associated heart diseases, including heart failure and myocardial infarction (MI). Here, we report a protective role of outer mitoc...

MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.

Naoki Ito Takara Takahashi Isshin Shiiba Shun Nagashima Ryoko Inatome Shigeru Yanagi

Journal of biochemistry 171(5) 529-541 2021年12月

The transfer of phospholipids from the endoplasmic reticulum to mitochondria via the mitochondria-endoplasmic reticulum (ER) contact site (MERCS) is essential for maintaining mitochondrial function and integrity. Here, we identified RMDN3/PTPIP51,...

Forebrain-specific deficiency of the GTPase CRAG/Centaurin-γ3 leads to immature dentate gyri and hyperactivity in mice.

Shun Nagashima Naoki Ito Reiki Kobayashi Isshin Shiiba Hiroki Shimura Toshifumi Fukuda Hideo Hagihara Tsuyoshi Miyakawa Ryoko Inatome Shigeru Yanagi

The Journal of biological chemistry 100620-100620 2021年3月

Mouse models of various neuropsychiatric disorders, such as schizophrenia, often display an immature dentate gyrus, characterized by increased numbers of immature neurons and neuronal progenitors and a dearth of mature neurons. We previously demon...

MITOL promotes cell survival by degrading Parkin during mitophagy.

Isshin Shiiba Keisuke Takeda Shun Nagashima Naoki Ito Takeshi Tokuyama Shun-Ichi Yamashita Tomotake Kanki Toru Komatsu Yasuteru Urano Yuuta Fujikawa Ryoko Inatome Shigeru Yanagi

EMBO reports 22(3) e49097 2021年3月

Parkin promotes cell survival by removing damaged mitochondria via mitophagy. However, although some studies have suggested that Parkin induces cell death, the regulatory mechanism underlying the dual role of Parkin remains unknown. Herein, we rep...