Yasuhisa Ano Yuta Takaichi Rena Ohya Kazuyuki Uchida Hiroyuki Nakayama Akihiko Takashima
Nutritional neuroscience 1-12 Jul 2022
Neurodegenerative diseases involving pathological tau protein aggregation are collectively known as tauopathies and include Alzheimer's disease and Pick's disease. Recent studies show that the intake of tryptophan-tyrosine (Trp-Tyr)-related β-lact...
Biochimica et biophysica acta. General subjects 1866(7) 130135-130135 Jul 2022
BACKGROUND: In Alzheimer's disease (AD), abnormally phosphorylated tau in the somatodendrite compartment of brain neurons causes synaptic loss, resulting in neuron death. Although the mechanism by which hyperphosphorylated tau appears in dendrites...
Fumiko Konishi Tadasu Furusho Yoshiyuki Soeda Jun Yamauchi Shoko Kobayashi Masatoshi Ito Takuma Araki Sarasa Kogure Akihiko Takashima Susumu Takekoshi
Scientific reports 12(1) 996-996 Jan 2022
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of extracellular amyloid-beta peptides (Aβ) resulting in senile plaques and intracellular hyperphosphorylated tau protein resulting in neurofibrillary tangl...
Communications biology 4(1) 1372-1372 Dec 2021 [Refereed]
<title>Abstract</title>The role of oligodendrocyte lineage cells, the largest glial population in the adult central nervous system (CNS), in the pathogenesis of Alzheimer’s disease (AD) remains elusive. Here, we developed a culture method for adul...
Graduate School of Humanities